Association of Helicobacter pylori Infection and Risk of Dyslipidemia: A Systematic Review and Meta‐Analysis DOI Creative Commons

Ankita Gaonkar,

Quazi Syed Zahiruddin, Muhammed Shabil

et al.

JGH Open, Journal Year: 2025, Volume and Issue: 9(3)

Published: March 1, 2025

ABSTRACT Background Although Helicobacter pylori ( H. ) infections are widespread throughout the world, it is yet unknown whether they linked to systemic illnesses like dyslipidemia. The purpose of this systematic review and meta‐analysis was examine connection between lipid metabolism infection, with a particular emphasis on how affects Methods We conducted thorough search up until October 10, 2024, across databases such as PubMed, Web Science, Embase. Studies that reported profiles in both ‐infected non‐infected patients were considered eligible. primary outcomes triglyceride, LDL‐C, HDL‐C, total cholesterol levels, which examined using random‐effects model R software version 4.4. Results There 17 studies more than 150,000 participants from 681 screened publications. Higher levels LDL (MD: 5.32 mg/dL; 95% CI: 1.315 9.319) 6.28 0.718 11.842), well lower HDL −2.06 −3.212 −0.915), results meta‐analysis. Among those infected, triglyceride likewise higher 7.93 0.413 15.436), but odds ratio (OR) did not show significant increase risk (OR: 1.002; 0.995 1.010). Conclusion infection associated dyslipidemia, suggesting potential link chronic bacterial metabolism. findings emphasize need for further research explore mechanisms therapeutic interventions.

Language: Английский

Relationship Between Human Microbiome and Helicobacter pylori DOI Creative Commons

Giada La Placa,

Marcello Covino,

Marcello Candeli

et al.

Microbiology Research, Journal Year: 2025, Volume and Issue: 16(1), P. 24 - 24

Published: Jan. 17, 2025

The enteric microbiota influences gene expression in the colonic epithelium. H. pylori (Helicobacter pylori) affects gastric growth factors, cytokines, and tumor cell markers, potentially benefiting host. interaction between human is complex but appears beneficial disease development. This publication discusses microbiota, microbiome, chronic colonization, bacterium’s role disease. interplay bacterium during infection also explored. gut has most abundant microbial community performs vital roles food digestion nutrient uptake, extraction of absorbable vitamins, inhibition pathogen colonization. Helicobacter a highly specialized pathogen, predominantly colonizing mucus layer, on or adherent to underlying epithelial surfaces. Many studies have suggested that microbiome related infection, some bacterial species can be used for detection diagnosis infection. Human genome analysis revolutionized our understanding intricate relationship humans their associated communities. integration data displayed promising capabilities occult detection, unveiling previously hidden pathologies providing opportunities early intervention. These groundbreaking discoveries paved way novel therapeutic strategies deeper comprehension interconnected nature overall health.

Language: Английский

Citations

0
Association of Helicobacter pylori Infection and Risk of Dyslipidemia: A Systematic Review and Meta‐Analysis DOI Creative Commons

Ankita Gaonkar,

Quazi Syed Zahiruddin, Muhammed Shabil

et al.

JGH Open, Journal Year: 2025, Volume and Issue: 9(3)

Published: March 1, 2025

ABSTRACT Background Although Helicobacter pylori ( H. ) infections are widespread throughout the world, it is yet unknown whether they linked to systemic illnesses like dyslipidemia. The purpose of this systematic review and meta‐analysis was examine connection between lipid metabolism infection, with a particular emphasis on how affects Methods We conducted thorough search up until October 10, 2024, across databases such as PubMed, Web Science, Embase. Studies that reported profiles in both ‐infected non‐infected patients were considered eligible. primary outcomes triglyceride, LDL‐C, HDL‐C, total cholesterol levels, which examined using random‐effects model R software version 4.4. Results There 17 studies more than 150,000 participants from 681 screened publications. Higher levels LDL (MD: 5.32 mg/dL; 95% CI: 1.315 9.319) 6.28 0.718 11.842), well lower HDL −2.06 −3.212 −0.915), results meta‐analysis. Among those infected, triglyceride likewise higher 7.93 0.413 15.436), but odds ratio (OR) did not show significant increase risk (OR: 1.002; 0.995 1.010). Conclusion infection associated dyslipidemia, suggesting potential link chronic bacterial metabolism. findings emphasize need for further research explore mechanisms therapeutic interventions.

Language: Английский

Citations

0