Demystifying the Potential of Polymeric Lipids as Substitute in Regenerative Applications: A Review
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(2)
Published: Feb. 1, 2025
ABSTRACT
The
objective
of
a
regenerative
medicine
is
to
repair,
restore,
and
regenerate
tissues
organs
that
occurred
due
injury
or
defect
disease.
Additionally,
the
purpose
reverse
aging
process
body
by
utilizing
body's
innate
healing
ability.
There
still
significant
venture
needs
be
directed
for
advancement
in
arena
medicine,
which
makes
use
products
derived
from
cell
therapy
as
well
biomedical.
Stem
cells
growth
factors
are
primary
components
medicine;
hence,
novel
drug
delivering
systems
now
being
studied
augment
transport
active
pharmaceuticals.
Lipid‐based
complexed
with
therapeutics
suited
site‐specific
controlled
release.
Lipids
biocompatible
available
various
sources
molecular
weights
self‐assemble
into
forms
hydrophilic
hydrophobic
parts.
By
enhancing
plasma
membrane
fluidity,
excipients
such
non‐ionic
surfactants,
fatty
acids,
glycerides
increase
permeability.
Liposomes,
nanoparticles,
nano‐emulsions,
micelles
nano‐lipid
carriers
can
improve
bioavailability
both
lipophilic
medicines.
lipoidal‐polymeric
had
emerged
promising
multifaceted
application
cytocompatibility,
ecofriendly,
ability
encapsulate
variety
drugs.
Further,
treatment
biomedical
tissue
engineering,
rapidly
developing
discipline.
Furthermore,
similar
vein,
delivery
technologies
combined
stem
promote
engraftment,
differentiation,
survival.
Hence
colloidal
carrier
has
impending
versatile
applications.
Therefore,
review
offer
an
abridged
information
on
significance
technology
offering
confined
ecosystem
facilitates
them
thrive
distinguish
effective
manner.
Language: Английский
In Vitro Evaluation of the Safety and Antineoplastic Effects in Gastrointestinal Tumors of Nanostructured Lipid Carriers Loaded with Berberine
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 331 - 331
Published: March 4, 2025
Background/Objectives:
Natural
substances
have
been
a
widely
studied
source
of
both
pharmaceutical
excipients
and
drugs.
Berberine
(BRB)
is
benzylisoquinoline
alkaloid
isolated
from
different
plant
sources.
It
possesses
various
pharmacological
properties
including
antibacterial,
antitumor,
antidiabetic,
neuroprotective,
hepatoprotective,
anti-inflammatory,
antioxidant,
etc.
However,
the
limited
aqueous
solubility
hinders
its
application.
Nanosized
drug
delivery
systems
are
an
innovative
approach
for
addressing
challenges
regarding
via
routes
administration.
Their
utilization
could
improve
active
constituents.
Methods:
A
melt-emulsification
ultrasonication
technique
was
applied
preparation
nanostructured
lipid
carriers
(NLCs).
They
were
thoroughly
physicochemically
characterized
by
means
Dynamic
Light
Scattering,
TEM,
FTIR,
DSC,
TGA,
In
Vitro
release.
The
efficacy
safety
evaluated
on
cholangiocarcinoma,
colorectal
adenocarcinoma,
hepatocellular
carcinoma,
lymphoma,
fibroblast,
cardioblast
cells,
as
well
rat
liver
microsomes
cytotoxicity
assays
comet
assay.
Results:
obtained
nanoparticles
had
spherical
shape
size
around
158.2
±
1.8
nm
with
negative
zeta
potential.
revealed
successful
loading
improved
dissolution
berberine
in
physiological
conditions.
studies
showed
that
BRB
NLCs
resulted
or
retained
to
tumor
cell
lines
reduced
normal
microsomes.
NLC
itself
increased
microsomal
malondialdehyde
(MDA)
formation.
Conclusions:
presented.
nanocarriers
show
favorable
physicochemical
biopharmaceutical
properties.
cellular
experiments
anticancer
safety.
These
findings
highlight
potential
applicability
gastrointestinal
neoplasms
build
foundation
future
practical
translation.
Language: Английский