Mitochondrial Dysfunction in Vascular Wall Cells and Its Role in Atherosclerosis DOI Open Access
Diana I. Salnikova,

Varvara A. Orekhova,

Andrey V. Grechko

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(16), P. 8990 - 8990

Published: Aug. 20, 2021

Altered mitochondrial function is currently recognized as an important factor in atherosclerosis initiation and progression. Mitochondrial dysfunction can be caused by DNA (mtDNA) mutations, which inherited or spontaneously acquired various organs tissues, having more less profound effects depending on the tissue energy status. Arterial wall cells are among most vulnerable to due their barrier metabolic functions. In atherosclerosis, mitochondria cause alteration of cellular metabolism respiration known produce excessive amounts reactive oxygen species (ROS) resulting oxidative stress. These processes involved vascular disease chronic inflammation associated with atherosclerosis. Currently, list mtDNA mutations human pathologies growing, many identified variants being tested markers. Alleviation stress appears promising for treatment. this review, we discuss role development, focusing key cell types arterial pathological processes. Accumulation isolated cells, such endothelial may contribute development local inflammatory process that helps explaining focal distribution atherosclerotic plaques surface. We also antioxidant anti-inflammatory approaches potentially reduce impact dysfunction.

Language: Английский

Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation DOI Creative Commons
Yingying Lü, Zhijia Li,

Shuangqian Zhang

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(2), P. 736 - 766

Published: Jan. 1, 2023

Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria through an autophagy mechanism, thus maintaining intracellular homeostasis.In recent years, has received increasing attention as a research hotspot related to the pathogenesis of clinical diseases, such neurodegenerative cardiovascular cancer, metabolic so on.It been found regulation may become new direction for treatment some diseases.In addition, numerous small molecule modulators have also reported, which provides opportunities comprehend procedure potential therapeutic development.Taken together, in this review, we summarize current understanding mechanism mitophagy, discuss roles its relationship with introduce existing small-molecule pharmacological further highlight significance their development.

Language: Английский

Citations

287
A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy DOI Creative Commons
Rekha Khandia, Maryam Dadar, Ashok Munjal

et al.

Cells, Journal Year: 2019, Volume and Issue: 8(7), P. 674 - 674

Published: July 3, 2019

Autophagy (self-eating) is a conserved cellular degradation process that plays important roles in maintaining homeostasis and preventing nutritional, metabolic, infection-mediated stresses. dysfunction can have various pathological consequences, including tumor progression, pathogen hyper-virulence, neurodegeneration. This review describes the mechanisms of autophagy its associations with other cell death mechanisms, apoptosis, necrosis, necroptosis, autosis. has both positive negative infection, cancer, neural development, metabolism, cardiovascular health, immunity, iron homeostasis. Genetic defects such as static childhood encephalopathy neurodegeneration adulthood, Crohn’s disease, hereditary spastic paraparesis, Danon X-linked myopathy excessive autophagy, sporadic inclusion body myositis. Further studies on different microbial infections could help to design develop novel therapeutic strategies against pathogenic microbes. progress prospects research activators suppressors, which be used intervention numerous diseases drugs protect human animal health.

Language: Английский

Citations

244
The mitophagy pathway and its implications in human diseases DOI Creative Commons

Shouliang Wang,

Haijiao Long,

Lianjie Hou

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Aug. 16, 2023

Abstract Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, crucial for metabolism survival. Mitophagy serves as a cytoprotective mechanism to remove superfluous or dysfunctional mitochondria maintain mitochondrial fine-tuning numbers balance intracellular homeostasis. Growing evidences show that mitophagy, an acute tissue stress response, plays important role maintaining the health of network. Since timely removal abnormal is essential survival, cells have evolved variety mitophagy pathways ensure can be activated time under various environments. A better understanding diseases treatment therapeutic target design. In this review, we summarize molecular mechanisms mitophagy-mediated elimination, how maintains homeostasis at system levels organ, what alterations related development diseases, including neurological, cardiovascular, pulmonary, hepatic, renal disease, etc., recent advances. Finally, potential clinical applications outline conditions regulators enter trials. Research advances signaling transduction will developing new strategies precision medicine.

Language: Английский

Citations

240
Role of Lipid Accumulation and Inflammation in Atherosclerosis: Focus on Molecular and Cellular Mechanisms DOI Creative Commons
Khojasteh Malekmohammad, Evgeny E. Bezsonov, Mahmoud Rafieian‐Kopaei

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2021, Volume and Issue: 8

Published: Sept. 6, 2021

Atherosclerosis is a chronic lipid-driven and maladaptive inflammatory disease of arterial intima. It characterized by the dysfunction lipid homeostasis signaling pathways that control inflammation. This article reviews role inflammation accumulation, especially low-density lipoprotein (LDL), in pathogenesis atherosclerosis, with more emphasis on cellular mechanisms. Furthermore, this review will briefly highlight medicinal plants, long non-coding RNA (lncRNA), microRNAs pathophysiology, treatment, prevention atherosclerosis. Lipid at various levels, including receptor-mediated uptake, synthesis, storage, metabolism, efflux, its impairments are important for development The major source cholesterol accumulation wall proatherogenic modified (mLDL). Modified lipoproteins, such as oxidized (ox-LDL) LDL binding proteoglycans extracellular matrix intima blood vessels, cause aggregation particles, endothelial damage, leukocyte recruitment, foam cell formation, Inflammation key contributor to atherosclerosis participates all phases Also, several studies have shown lncRNAs appeared regulators physiological pathophysiological processes regulation HDL biogenesis, regulating smooth muscle proliferation, controlling Thus, both immune response closely linked, their molecular interact each other.

Language: Английский

Citations

202
Outstanding Questions in Mitophagy: What We Do and Do Not Know DOI
Lambert Montava‐Garriga, Ian G. Ganley

Journal of Molecular Biology, Journal Year: 2019, Volume and Issue: 432(1), P. 206 - 230

Published: July 9, 2019

Language: Английский

Citations

181
SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy DOI Creative Commons
Xingyu Li, Peili Hou, Wenqing Ma

et al.

Cellular and Molecular Immunology, Journal Year: 2021, Volume and Issue: 19(1), P. 67 - 78

Published: Nov. 29, 2021

The global coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome 2 (SARS-CoV-2) has morbidity and mortality in humans. It is urgent to understand the function of viral genes. However, open reading frame 10 (ORF10), which uniquely expressed SARS-CoV-2, remains unclear. In this study, we showed that overexpression ORF10 markedly suppressed expression type I interferon (IFN-I) genes IFN-stimulated Then, mitochondrial antiviral signaling protein (MAVS) was identified as target via suppresses IFN-I pathway, MAVS found be degraded through ORF10-induced autophagy pathway. Furthermore, promoted accumulation LC3 mitochondria induced mitophagy. Mechanistically, translocated interacting with mitophagy receptor Nip3-like X (NIX) its interaction both NIX LC3B. Moreover, knockdown blocked activation, degradation, pathway inhibition ORF10. Consistent our observations, context SARS-CoV-2 infection, inhibited facilitated replication. brief, results reveal a novel mechanism inhibits innate immune response; is, induces mitophagy-mediated degradation binding NIX.

Language: Английский

Citations

165
Autophagy in the diabetic heart: A potential pharmacotherapeutic target in diabetic cardiomyopathy DOI
Saikat Dewanjee, V. Jayalakshmi, Rajkumar Singh Kalra

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 68, P. 101338 - 101338

Published: April 7, 2021

Language: Английский

Citations

130
Molecular and cellular pathways contributing to brain aging DOI Creative Commons

Aliabbas Zia,

Ali Mohammad Pourbagher‐Shahri, Tahereh Farkhondeh

et al.

Behavioral and Brain Functions, Journal Year: 2021, Volume and Issue: 17(1)

Published: June 12, 2021

Abstract Aging is the leading risk factor for several age-associated diseases such as neurodegenerative diseases. Understanding biology of aging mechanisms essential to pursuit brain health. In this regard, defined by a gradual decrease in neurophysiological functions, impaired adaptive neuroplasticity, dysregulation neuronal Ca 2+ homeostasis, neuroinflammation, and oxidatively modified molecules organelles. Numerous pathways lead aging, including increased oxidative stress, inflammation, disturbances energy metabolism deregulated autophagy, mitochondrial dysfunction, IGF-1, mTOR, ROS, AMPK, SIRTs, p53 central modulators metabolic control, connecting pathways, which disorders. Also, calorie restriction (CR), physical exercise, mental activities can extend lifespan increase nervous system resistance The neuroprotective effect CR involves protection against ROS generation, maintenance cellular inhibition apoptosis. recent evidence about modem molecular methods neurobiology exhibiting significant potential cells adaptation

Language: Английский

Citations

128
Pathophysiology of sepsis DOI
Pietro Arina, Mervyn Singer

Current Opinion in Anaesthesiology, Journal Year: 2021, Volume and Issue: 34(2), P. 77 - 84

Published: Feb. 4, 2021

Purpose of review To provide a current overview sepsis pathophysiology. Recent findings The emphasis on pathophysiology has moved away from the pathogen - initiating factor and instead is focussed upon abnormal exaggerated host response. Instead targeted eradication infection, response activates or suppresses multiple downstream pathways, leading to organ dysfunction. Summary Sepsis represents dysregulated infection Here, triggers an initial inflammatory-immune that leads activation suppression endothelial, hormonal, bioenergetic, metabolic, immune, other pathways. These, in turn, produce circulatory metabolic perturbations resulting This will underlying mechanisms propose these processes, whereas superficially viewed as dysfunctional, may actually be adaptive/protective first instance, though spilling over into maladaptation/harm depending magnitude

Language: Английский

Citations

110
Cornuside alleviates cognitive impairments induced by Aβ1−42 through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy DOI Creative Commons

Fulin Zhou,

Wenwen Lian,

Xiaotang Yuan

et al.

Alzheimer s Research & Therapy, Journal Year: 2025, Volume and Issue: 17(1)

Published: Feb. 19, 2025

Language: Английский

Citations

5