KLF transcription factors in bone diseases

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(8)

Published: March 28, 2024

Abstract Krüppel‐like factors (KLFs) are crucial in the development of bone disease. They a family zinc finger transcription that unusual containing three highly conserved structural domains interacting with DNA. It has been discovered it engages various cell functions, including proliferation, apoptosis, autophagy, stemness, invasion and migration, is for human tissues. In recent years, role KLFs physiology pathology received adequate attention. addition to regulating normal growth musculoskeletal system, participate pathological process bones joints intimately linked several skeletal illnesses, such as osteoarthritis (OA), rheumatoid arthritis (RA), osteoporosis (OP) osteosarcoma (OS). Consequently, targeting emerged promising therapeutic approach an array disorders. this review, we summarize current literature on importance emergence regulation particular emphasis pertinent mechanisms by which regulate diseases. We also discuss need KLFs‐based medication‐targeted treatment. These endeavours offer new perspectives use disorders provide prognostic biomarkers, targets possible drug candidates

Language: Английский

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The Role of Traditional Chinese Medicines in the Treatment of Osteoporosis

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: 52(04), P. 949 - 986

Published: Jan. 1, 2024

Osteoporosis (OP) represents a substantial public health issue and is associated with increasing rates of morbidity mortality. It characterized by reduced bone mineral density, deterioration tissue quality, disruption the microarchitecture bones, compromised strength. These changes may be attributed to following factors: intercellular communication between osteoblasts osteoclasts; imbalanced remodeling; imbalances osteogenesis adipogenesis; in hormonal regulation; angiogenesis; chronic inflammation; oxidative stress; intestinal microbiota imbalances. Treating single aspect disease insufficient address its multifaceted nature. In recent decades, traditional Chinese medicine (TCM) has shown great potential treatment OP, therapeutic effects patent drugs medicinal herbs have been scientifically proven. TCMs, which contain multiple components, can target diverse pathogeneses OP through multitargeted approach. Herbs such as XLGB, JTG, GSB, Yinyanghuo, Gusuibu, Buguzhi, Nvzhenzi are among TCMs that used treat demonstrated promising this context. They exert their targeting various pathways involved metabolism. balance activity (bone-forming cells) osteoclasts (bone-resorbing cells), they exhibit anti-inflammatory, immunomodulatory, anti-oxidative, estrogen-like functions. mechanisms underlie efficacy these management OP. Herein, we examine treating reviewing previous clinical trials basic experiments, mechanism therapies provide evidence regarding use TCM for

Language: Английский

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Advances in the interaction between endoplasmic reticulum stress and osteoporosis

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115134 - 115134

Published: July 10, 2023

The endoplasmic reticulum (ER) is the main site for protein synthesis, folding, and secretion, accumulation of unfolded/misfolded proteins in ER may induce stress. stress an important participant various intracellular signaling pathways. Prolonged- or high-intensity cell apoptosis. Osteoporosis, characterized by imbalanced bone remodeling, a global disease caused many factors, such as stimulates osteoblast apoptosis, increases loss, promotes osteoporosis development. Many drug's adverse effects, metabolic disorders, calcium ion imbalance, bad habits, aging, have been reported to activate stress, resulting pathological development osteoporosis. Increasing evidence shows that regulates osteogenic differentiation, activity, osteoclast formation function. Various therapeutic agents developed counteract thereby suppress Thus, inhibition has become potential target management However, in-depth understanding pathogenesis still needs more effort.

Language: Английский

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Targeting proteostasis network in osteoporosis: Pathological mechanisms and therapeutic implications

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 90, P. 102024 - 102024

Published: July 31, 2023

As the most common bone disease, osteoporosis (OP) increases fragility and makes patients more vulnerable to threat of osteoporotic fractures. With ageing population in today's society, OP has become a huge growing public health problem. Unfortunately, clear pathogenesis is still under exploration, effective interventions are scarce. Therefore, exploring new targets for pharmacological develop promising therapeutic drugs great clinical value. Previous studies have shown that normal remodeling depends on proteostasis, whereas loss proteostasis during leads dysfunctional network (PN) fails maintain homeostasis. Nevertheless, only few revealed pathophysiological relationship between metabolism single component PN, yet role PN as whole investigation. This review comprehensively summarized further discussed potential innovative drug therapy OP.

Language: Английский

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DNAzyme Nanoconstruct-Integrated Autonomously-Adaptive Coatings Enhance Titanium-Implant Osteointegration by Cooperative Angiogenesis and Vessel Remodeling

ACS Nano, Journal Year: 2023, Volume and Issue: 17(16), P. 15942 - 15961

Published: Aug. 11, 2023

Orthopedic implants have a high failure rate due to insufficient interfacial osseointegration, especially under osteoporotic conditions. Type H vessels are CD31+EMCN+ capillaries with crucial roles in mediating new bone formation, but their abundance fracture site is highly limited. Herein, we report nanoengineered composite coating improve the situ osseointegration of Ti implant for repair, which realized through inhibiting stimulator interferon genes (STING) endothelial cells (ECs) stimulate type vessel formation. Autonomously catalytic DNAzyme-ZnO nanoflowers (DNFzns) were prepared rolling circle amplification (RCA) STING mRNA-degrading DNAzymes, then integrated on surface and further sequentially complexed thioketal-bridged polydopamine naringenin (Ti/DNFzn/PDA-Nar). ECs mesenchymal stem (MSCs) can be recruited by galvanotaxis, accounting negative charges DNFzn/PDA-Nar, subsequently released Nar reactive oxygen species (ROS) stimulation upregulate nitric oxide synthase (eNOS) ECs, leading enhanced local angiogenesis. Meanwhile, coordinately DNFzns would abolish expression transform newly formed into vessels, thus substantially promoting implants. This study provides application prospects improving osteointegration treatment.

Language: Английский

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