Neuron-Glial2 (NG2) Cells: A Promising Target for Neuroinflammation-Related Neurodegeneration

Translational Research in Anatomy, Journal Year: 2025, Volume and Issue: unknown, P. 100395 - 100395

Published: March 1, 2025

Language: Английский

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Pathophysiologic Mechanisms of Severe Spinal Cord Injury and Neuroplasticity Following Decompressive Laminectomy and Expansive Duraplasty: A Systematic Review

Neurology International, Journal Year: 2025, Volume and Issue: 17(4), P. 57 - 57

Published: April 16, 2025

Background: Severe spinal cord injury (SCI) represents a debilitating condition with long-term physical and socioeconomic impacts. Understanding the pathophysiology of SCI therapeutic interventions such as decompressive laminectomy expansive duraplasty is crucial for optimizing patient outcomes. Objective: This systematic review explores evaluates evidence linking to improved neuroplasticity recovery. Methods: A comprehensive search was conducted in PubMed, Web Science, Cochrane Library studies on surgery SCI. Inclusion criteria were original articles investigating pathophysiology, mechanisms, or surgical Data pathophysiological changes, molecular markers, functional outcomes extracted. Results: From 1240 initial articles, 43 included, encompassing both animal models human clinical data. Findings highlighted role inflammatory cascades, blood–spinal barrier disruption, neurotrophic factor modulation Decompressive associated intrathecal pressure (ITP) management BDNF GAP-43. Conclusions: underscores potential While suggests benefits promoting neuroplasticity, further research needed elucidate mechanisms refine interventions.

Language: Английский

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Multiple strategies enhance the efficacy of MSCs transplantation for spinal cord injury

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 157, P. 114011 - 114011

Published: Nov. 18, 2022

Spinal cord injury (SCI) is a serious complication of the central nervous system (CNS) after spine injury, often resulting in severe sensory, motor, and autonomic dysfunction below level injury. To date, there no effective treatment strategy for SCI. Recently, stem cell therapy has brought hope to patients with neurological diseases. Mesenchymal cells (MSCs) are considered be most promising source cellular SCI due their immunomodulatory, neuroprotective angiogenic potential. Considering limited therapeutic effect MSCs complex pathophysiological environment following SCI, this paper not only reviews specific mechanism facilitate repair, but also further discusses research status these pluripotent combined other approaches promote anatomical functional recovery post-SCI.

Language: Английский

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Mesenchymal Stem Cell Transplantation: Neuroprotection and Nerve Regeneration After Spinal Cord Injury

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 4763 - 4776

Published: Oct. 1, 2023

Spinal Cord Injury (SCI), with its morbidity characteristics of high disability rate and mortality rate, is a disease that highly destructive to both the physiology psychology patient, for which there still lack effective treatment. Following spinal cord injury, cascade secondary injury reactions known as ischemia, peripheral inflammatory cell infiltration, oxidative stress, etc. create microenvironment unfavorable neural recovery ultimately results in apoptosis necrosis neurons glial cells. Mesenchymal stem (MSC) transplantation has emerged more promising therapeutic options recent years. MSC can promote repair through variety mechanisms, including immunomodulation, neuroprotection, nerve regeneration, giving patients hope. In this paper, it discussed neuroprotection regeneration components MSCs' method treating injuries.

Language: Английский

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The phenotypic changes of Schwann cells promote the functional repair of nerve injury

Neuropeptides, Journal Year: 2024, Volume and Issue: 106, P. 102438 - 102438

Published: May 11, 2024

Language: Английский

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