Oncolytic virus and tumor-associated macrophage interactions in cancer immunotherapy

Clinical and Experimental Medicine, Journal Year: 2024, Volume and Issue: 24(1)

Published: Aug. 28, 2024

Abstract Oncolytic viruses (OV) are a promising strategy in cancer immunotherapy. Their capacity to promote anti-tumoral immunity locally raises hope that cancers unresponsive current immunotherapy approaches could be tackled more efficiently. In this context, tumor-associated macrophages (TAM) must considered because of their pivotal role immunity. Even though TAM tend inhibit responses, ability secrete pro-inflammatory cytokines and phagocytose cells can harnessed therapeutic OVs have the potential functions favor But parallel, induce OV clearance tumor, thereby limiting efficacy highlighting interaction between is double edge sword. Moreover, engineered were recently developed modulate specific such as phagocytic activity. The circulating monocytes deliver into tumor after intravenous administration also emerging. review, we will present TAM, functions, delivery tumor.

Language: Английский

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Proliferation of monocytes and macrophages in homeostasis, infection, injury, and disease

Journal of Leukocyte Biology, Journal Year: 2023, Volume and Issue: 114(6), P. 532 - 546

Published: Aug. 9, 2023

Abstract Monocytes (Mo) and macrophages (Mφ) play important roles in the function of tissues, organs, systems all animals during homeostasis, infection, injury, disease. For decades, conventional wisdom has dictated that Mo Mφ are end-stage cells do not proliferate accumulation tissues is result infiltration from blood subsequent differentiation to Mφ. However, reports early 1900s present describe evidence proliferation different contexts. The purpose this review summarize both historical current for contribution their organs including skin, peritoneum, lung, heart, aorta, kidney, liver, pancreas, brain, spinal cord, eye, adipose tissue, uterus, species mouse, rat, rabbit, human. can at stages with infiltrating Mo-like proliferating certain inflammatory contexts (e.g. skin wounding, kidney bladder liver infection) mature resident other nematode acetaminophen injury) homeostasis. pathways involved stimulating also may be context dependent, cytokines transcription factors implicated studies. Although known health, disease, much remains learned about regulation its impact on repair tissues.

Language: Английский

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In vivo inhibition of nuclear ACE2 translocation protects against SARS-CoV-2 replication and lung damage through epigenetic imprinting

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: June 27, 2023

Abstract In vitro, ACE2 translocates to the nucleus induce SARS-CoV-2 replication. Here, using digital spatial profiling of lung tissues from SARS-CoV-2-infected golden Syrian hamsters, we show that a specific and selective peptide inhibitor nuclear (NACE2i) inhibits viral replication two days after infection. Moreover, also prevents inflammation macrophage infiltration, increases NK cell infiltration in bronchioles. NACE2i treatment levels active histone mark, H3K27ac, restores host translation infected hamster bronchiolar cells, leads an enrichment methylated bronchioles macrophages, signature associated with virus protection. addition, methylation is increased myeloid cells vaccinated patients reduced spike protein expression monocytes individuals who have recovered This protective epigenetic scarring latent reservoir monocytes/macrophages enhanced immune protection against SARS-CoV-2. Nuclear may represent therapeutic target independent variant strain viruses use receptor for entry.

Language: Английский

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Pseudoephedrine: A Review and Benefit-Risk Assessment with Reference to the Risk of Posterior Reversible Encephalopathy Syndrome (PRES) and Reversible Cerebral Vasoconstriction Syndrome (RCVS)

Open Journal of Respiratory Diseases, Journal Year: 2025, Volume and Issue: 15(01), P. 19 - 34

Published: Jan. 1, 2025

Pseudoephedrine (PSE) is a widely used nasal decongestant. A review by the European Medicines Agency has reported that PSE may be associated with risks of posterior reversible encephalopathy syndrome (PRES) and cerebral vasoconstriction (RCVS). PRES RCVS are rare but serious conditions affect blood flow. This discusses pharmacology potential for concludes considering common use PSE, over 70 million packs taken each year in Union United Kingdom, occurrence RCVS, developing PRES/RCVS on exposure to likely very low.

Language: Английский

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Monitoring Macrophage Polarization in Infectious Disease, Lesson From SARS‐CoV‐2 Infection

Reviews in Medical Virology, Journal Year: 2025, Volume and Issue: 35(3)

Published: March 27, 2025

The concept of macrophage polarization has been largely used in human diseases to define a typology activation myeloid cells reminiscent lymphocyte functional subsets. In COVID-19, several studies have investigated compartment dysregulation and as an indicator disease prognosis monitoring. SARS-CoV-2 induces vitro state monocytes macrophages that does not match the categories most studies. COVID-19 patients, are activated but they do show profile. Therefore, investigation under basic conditions was relevant assess monocyte activation. analysis with high-throughput methods allowed identification new subsets context COVID-19. This approach proposes innovative stratification cell These would be better biomarkers risk complications reserving for pharmacological programme evaluation. review reappraises viral infections, particularly

Language: Английский

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Monitoring Macrophage Polarization in Infectious Disease, Lesson From SARS‐CoV‐2 Infection

Reviews in Medical Virology, Journal Year: 2025, Volume and Issue: 35(3)

Published: April 7, 2025

ABSTRACT The concept of macrophage polarization has been largely used in human diseases to define a typology activation myeloid cells reminiscent lymphocyte functional subsets. In COVID‐19, several studies have investigated compartment dysregulation and as an indicator disease prognosis monitoring. SARS‐CoV‐2 induces vitro state monocytes macrophages that does not match the categories most studies. COVID‐19 patients, are activated but they do show profile. Therefore, investigation under basic conditions was relevant assess monocyte activation. analysis with high‐throughput methods allowed identification new subsets context COVID‐19. This approach proposes innovative stratification cell These would be better biomarkers risk complications reserving for pharmacological programme evaluation. review reappraises viral infections, particularly

Language: Английский

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Annexin A1-FPR2/ALX Signaling Axis Regulates Acute Inflammation during Chikungunya Virus Infection

Cells, Journal Year: 2022, Volume and Issue: 11(17), P. 2717 - 2717

Published: Aug. 31, 2022

Chikungunya (CHIKV) is an arthritogenic alphavirus that causes a self-limiting disease usually accompanied by joint pain and/or polyarthralgia with disabling characteristics. Immune responses developed during the acute phase of CHIKV infection determine rate progression and resolution. Annexin A1 (AnxA1) involved in both initiating inflammation preventing over-response, being essential for balanced end inflammation. In this study, we investigated role AnxA1-FPR2/ALX pathway infection. Genetic deletion AnxA1 or its receptor enhanced inflammatory driven CHIKV. These knockout mice showed increased neutrophil accumulation augmented tissue damage at site compared control mice. Conversely, treatment wild-type animals mimetic peptide (Ac2–26) reduced accumulation, decreased local concentration mediators diminished mechanical hypernociception paw edema induced CHIKV-infection. Alterations viral load were mild genetic treatment. Combined, our data suggest potential therapeutic strategy to CHIKV-induced polyarthralgia.

Language: Английский

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Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 9, 2022

B cell lymphoma 2 (BCL-2) family proteins are involved in the mitochondrial apoptotic pathway and key modulators of cellular lifespan, which is dysregulated during human immunodeficiency virus type 1 (HIV-1) other viral infections, thereby increasing lifespan cells harboring virus, including latent HIV-1 reservoir. Long-lived integrated DNA a major barrier to eradication. Strategies reducing reservoir could significantly impact field cure research, while also providing insight into immunomodulatory strategies that can crosstalk infections. Venetoclax first-in-class orally bioavailable BCL-2 homology 3 (BH3) mimetic recently received Food Drug Administration (FDA) approval for treatment myeloid lymphocytic leukemia. has been investigated demonstrated anti-HIV-1 effects reduction size. Another strategy towards Jak 1/2 inhibition. The STAT implicated interleukin 10 (IL-10) expression, leading downstream effect senescence. Ruxolitinib baricitinib FDA-approved, inhibitors have shown indirectly decay reservoir, down-regulate markers persistence, immune dysregulation vitro ex vivo . significant decrease expression study virally suppressed people living with HIV (PWH), emergency use indication coronavirus disease 2019 (COVID-19), underscoring their safety efficacy infection setting. be repurposed as immunomodulators not only COVID-19, but viruses upregulate anti-apoptotic proteins. This review examines potential routes

Language: Английский

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Nobiletin Regulates Polyinosinic-polycytidylic Acid-induced Inflammation in Macrophages Partially via the PPAR-γ Signaling Pathway

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(37), P. 2937 - 2946

Published: Aug. 12, 2024

Macrophage dysregulation is a common pathogenic feature of viruses that provides extensive targets for antiviral therapy. Nobiletin, polymethoxylated flavonoid found in citrus fruits, has multitude effects.

Language: Английский

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Airway and Blood Monocyte Transcriptomic Profiling Reveals an Antiviral Phenotype in Infants With Severe Respiratory Syncytial Virus Infection

The Journal of Infectious Diseases, Journal Year: 2023, Volume and Issue: 229(Supplement_1), P. S100 - S111

Published: Nov. 2, 2023

Abstract Background Respiratory syncytial virus (RSV) infection is the primary cause of lower respiratory tract infections in children <5 years age. Monocytes, especially tract, are suggested to contribute RSV pathology, but their role incompletely understood. With transcriptomic profiling blood and airway monocytes, we describe monocytes severe infection. Methods Tracheobronchial aspirates samples were collected from control patients (n = 9) those infected with 14) who admitted pediatric intensive care unit. Monocytes (CD14+) sorted analyzed by RNA sequencing for profiling. Results Peripheral demonstrated increased expression antiviral interferon-responsive genes as compared controls. Cytokine signaling showed a shared response between while displaying responses that more pronounced according tissue origin. Airway upregulated additional related migration inflammation. Conclusions We found RSV-induced interferon extends airways peripheral blood. Moreover, induces migration-promoting transcriptional program monocytes. Unraveling monocytic its immune could help development therapeutics prevent disease.

Language: Английский

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