Comparison of C-reactive protein with distinct hyperinflammatory biomarkers in association with COVID-19 severity, mortality and SARS-CoV-2 variants

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 14, 2023

C-reactive protein (CRP) has been one of the most investigated inflammatory-biomarkers during ongoing COVID-19 pandemics caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The outcome among patients with SARS-CoV-2 infection is closely related to cytokine storm and hyperinflammation responsible for distress multiple organ failure. It still remains a challenge determine which hyperinflammatory biomarkers cytokines are best predictors disease severity mortality in patients. Therefore, we evaluated compared prediction efficiencies between CRP, recently reported inflammatory modulators (suPAR, sTREM-1, HGF), classical (MCP-1, IL-1β, IL-6, NLR, PLR, ESR, ferritin, fibrinogen, LDH) confirmed at hospital admission. Notably, had higher serum levels suPAR, HGF mild moderate cases. Our data also identified all analytes, discriminate non-severe forms disease, while LDH, sTREM-1 proved be excellent Importantly, suPAR emerged as key molecule characterizing Delta variant infections.

Language: Английский

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Associations between plasma inflammatory markers and psychotic disorder, depressive disorder and generalised anxiety disorder in early adulthood: A nested case-control study

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 111, P. 90 - 100

Published: March 31, 2023

Low-grade inflammation may occur in association with several mental disorders of early adulthood, though associations markers chronic such as soluble urokinase plasminogen activator receptor (suPAR) are less well-established. We aimed to examine between acute and inflammatory disorders, well psychiatric co-morbidity, young adults aged 24 years the Avon Longitudinal Study Parents Children.Included were 781 participants (of 4019 who attended at age years) completed assessments provided plasma samples. Of these, 377 met criteria for psychotic disorder, depressive disorder or generalised anxiety 404 did not. Plasma concentrations IFN-γ, IL-6, IL-8, IL-10, TNF-α, CRP, sVCAM1, sICAM1, suPAR alpha-2-macroglobulin measured using immunoassays. Logistic regression compared standardised marker levels cases controls. Negative binomial evaluated co-morbidity (number disorders). Models adjusted sex, body mass index, cigarette smoking, cannabis use employment status, then additionally childhood trauma.For there was evidence IL-6 (odds ratio[OR] 1.68, 95 %CI 1.20-2.34) (OR 1.74, 1.17-2.58). There weaker an 1.31, 1.05-1.62). little disorder. weak (β 0.10, 0.01-0.19). additional confounding by trauma.There that 24-year-olds had raised These findings have implications regarding role adulthood.

Language: Английский

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qSOFA combined with suPAR for early risk detection and guidance of antibiotic treatment in the emergency department: a randomized controlled trial

Critical Care, Journal Year: 2024, Volume and Issue: 28(1)

Published: Feb. 6, 2024

Abstract Background Sepsis guidelines suggest immediate start of resuscitation for patients with quick Sequential Organ Failure Assessment (qSOFA) 2 or 3. However, the interpretation qSOFA 1 remains controversial. We investigated whether measurements soluble urokinase plasminogen activator receptor (suPAR) may improve risk detection when is 1. Methods The study had two parts. At first part, combination suPAR was analyzed in a prospective cohort early detection. second double-blind, randomized controlled trial (RCT) SUPERIOR evaluated efficacy suPAR-guided medical intervention. took place between November 2018 and December 2020. Multivariate stepwise Cox regression used cohort, while univariate multivariate logistic RCT. Consecutive admissions at emergency department (ED) suspected infection, ≥ 12 ng/mL were allocated to single infusion placebo meropenem. primary endpoint deterioration, defined as least one-point increase admission (SOFA) score 24 h. Results Most mortality Taking hazard ratio (HR) death = < reference, HR 28-day 2.98 (95% CI 2.11–3.96). RCT prematurely ended due pandemia-related ED re-allocations, 91 enrolled: 47 44 meropenem arm. met 40.4% ( n 19) 15.9% 7), respectively (difference 24.5% [5.9–40.8]; odds 0.14 [0.04–0.50]). One post hoc analysis showed significant median changes SOFA after 72 96 h equal 0 − 1, respectively. Conclusions Combining biomarker improves its prognostic performance unfavorable outcome can help decision earlier treatment. Trial registration EU Clinical Trials Register (EudraCT, 2018-001008-13) Clinical-Trials.gov (NCT03717350). Registered October 2018.

Language: Английский

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Development and validation of prognostic machine learning models for short- and long-term mortality among acutely admitted patients based on blood tests

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 11, 2024

Abstract Several scores predicting mortality at the emergency department have been developed. However, all with shortcomings either simple and applicable in a clinical setting, poor performance, or advanced, high but clinically difficult to implement. This study aimed explore if machine learning algorithms could predict all-cause short- long-term based on routine blood test collected admission. Methods: We analyzed data from retrospective cohort study, including patients > 18 years admitted Emergency Department (ED) of Copenhagen University Hospital Hvidovre, Denmark between November 2013 March 2017. The primary outcomes were 3-, 10-, 30-, 365-day after PyCaret, an automated library, was used evaluate predictive performance fifteen using area under receiver operating characteristic curve (AUC). Results: Data 48,841 admissions analyzed, these 34,190 (70%) randomly divided into training data, 14,651 (30%) data. Eight achieved very good excellent results AUC range 0.85–0.93. In prediction short-term mortality, lactate dehydrogenase (LDH), leukocyte counts differentials, Blood urea nitrogen (BUN) mean corpuscular hemoglobin concentration (MCHC) best predictors, whereas favored by age, LDH, soluble urokinase plasminogen activator receptor (suPAR), albumin, (BUN). Conclusion: findings suggest that measures biomarkers taken one sample during admission ED can identify risk short-and following admissions.

Language: Английский

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Soluble Urokinase Plasminogen Activator Receptor (suPAR) Independently Predicts Severity and Length of Hospitalisation in Patients With COVID-19

Frontiers in Medicine, Journal Year: 2021, Volume and Issue: 8

Published: Dec. 2, 2021

Efficient healthcare based on prognostic variables in hospitalised patients with COVID-19 could reduce the risk of complications and death. Recently, soluble urokinase Plasminogen Activator Receptor (suPAR) was shown to predict respiratory failure, kidney injury, clinical outcome SARS-CoV-2 infection. The aim this study investigate value suPAR as a tool, comparison other variables, regarding disease severity length hospital stay COVID-19.

Language: Английский

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The Role of the Plasminogen/Plasmin System in Inflammation of the Oral Cavity

Cells, Journal Year: 2023, Volume and Issue: 12(3), P. 445 - 445

Published: Jan. 30, 2023

The oral cavity is a unique environment that consists of teeth surrounded by periodontal tissues, mucosae with minor salivary glands, and terminal parts major glands open into the cavity. constantly exposed to viral microbial pathogens. Recent studies indicate components plasminogen (Plg)/plasmin (Pm) system are expressed in tissues cavity, such as gland, contribute infection inflammation, periodontitis. Plg/Pm fulfills two functions: (a) destruction fibrin deposits bloodstream or damaged process called fibrinolysis, (b) non-fibrinolytic actions include proteolytic modulation proteins. One can observe both functions during inflammation. virus causes coronavirus disease 2019 (COVID-19) exploits fibrinolytic During COVID-19, well-established coagulopathy development microthrombi requires constant activation function. Furthermore, entry modulated receptors TMPRSS2, which necessary leading derailed immune response peaks cytokine storm syndrome. This paper outlines significance for infectious inflammatory diseases start

Language: Английский

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Real-Life Comparison of Four JAK Inhibitors in Rheumatoid Arthritis (ELECTRA-i Study)

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(6), P. 1821 - 1821

Published: March 21, 2024

Background: Real-world evidence of the efficacy and adverse events JAK inhibitor treatment (Tofacitinib, Baricitinib, Upadacitinib, Filgotinib) in rheumatoid arthritis is still limited. Methods: We studied 115 patients from Rheumatology Unit S. Giovanni di Dio Hospital affected by D2T-RA, according to 2010 EULAR criteria. Out patients, 17 had been treated with Baricitinib 8 mg/daily, 32 Filgotinib 200 21 Tofacitinib 10 45 Upadacitinib 15 mg/daily. evaluated clinical response after 3, 6, 12 months follow-up September 2022 2023. All were number tender joints (NTJs), swollen (NSJs), visual analog scale (VAS), global assessment (GA), health questionnaire (HAQ), Disease Activity Score (DAS28), CDAI. Furthermore, laboratory parameters tolerability evaluated. Results: treatments demonstrated a statistically significant decrease DAS28 CDAI scores, joint counts, VAS, HAQ, patient (PGA) treatment. showed similar behavior, decreases circulating calprotectin, TNFα, IL-6 observed for all drugs In addition, soluble urokinase plasminogen activator receptor (suPAR) values differences at baseline Filgotinib: 4.87 ± 4.53 vs. 3.61 0.9 (0.009) Upadacitinib: 6.64 7.12 4.06 (0.0003), while no found Baricitinib: 3.4 0.1 3.78 Tofacitinib: 3.95 1.77 2.58 0.1. The TC/HDL-C ratio (atherogenic index) when comparing (0.0012), (0.0095), (0.0001); furthermore, LDL-C/HDL-C group did not change (2.37 0.45 2.35 2.13 (NS)) Venous Thrombotic Events (VTEs) major cardiovascular (MACEs) accounted 1% Baricitinib. Herpes zoster reactivation Tofacitinib, non-melanoma skin cancer (NMSC) Conclusions: Our real-world data RA show some impact lipid metabolism

Language: Английский

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suPAR in cardiovascular disease

Advances in clinical chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 89 - 131

Published: Jan. 1, 2024

Language: Английский

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Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases

Mechanisms of Ageing and Development, Journal Year: 2024, Volume and Issue: 222, P. 111995 - 111995

Published: Oct. 9, 2024

Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as senotherapeutic agent the treatment of age-related chronic diseases. Senotherapeutics target senescent cells, which accumulate with age disease, both circulating immune cell populations solid organs tissues. Senescent cells contribute to development many diseases, primarily by eliciting systemic inflammation through their senescence-associated secretory phenotype. Here, we explore whether fisetin can eliminate thereby alleviate examining current evidence from vitro studies animal models that investigate fisetin's impact on well phase I/II trials various patient populations. We discuss application humans, including challenges future directions. Our review available data suggests targeting offers promising strategy managing multiple potentially transforming healthcare older multimorbid patients. However, further are needed establish safety, pharmacokinetics, efficacy senotherapeutic, identify relevant reliable outcome measures human trials, optimize dosing, better understand possible limitations agent.

Language: Английский

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RAGE pathway activation and function in chronic kidney disease and COVID-19

Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 9, 2022

The multi-ligand receptor for advanced glycation end-products (RAGE) and its ligands are contributing factors in autoimmunity, cancers, infectious disease. RAGE activation is increased chronic kidney disease (CKD) coronavirus 2019 (COVID-19). CKD may increase the risk of COVID-19 severity also develop form long COVID. expressed essentially all cell types. Increased production isoforms during promotes activity. downstream effects include cellular dysfunction, tissue injury, fibrosis, inflammation, which turn contribute to a decline function, hypertension, thrombotic disorders, cognitive impairment. In this review, we discuss forms mechanisms COVID-19. Because various small molecules antagonize activity animal models, targeting RAGE, co-receptors, or offer novel therapeutic approaches slowing halting progressive disease, current therapies often inadequate.

Language: Английский

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