Gut Microbiome Composition and Its Metabolites Are a Key Regulating Factor for Malignant Transformation, Metastasis and Antitumor Immunity

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5978 - 5978

Published: March 22, 2023

The genetic and metabolomic abundance of the microbiome exemplifies that comprises a more extensive set genes than entire human genome, which justifies numerous metabolic immunological interactions between gut microbiota, macroorganisms immune processes. These have local systemic impacts can influence pathological process carcinogenesis. latter be promoted, enhanced or inhibited by microbiota host. This review aimed to present evidence host might significant exogenic factor for cancer predisposition. It is beyond doubt cross-talk cells in terms epigenetic modifications regulate gene expression patterns cell fate both beneficial adverse directions host’s health. Furthermore, bacterial metabolites could shift pro- anti-tumor processes one direction another. However, exact mechanisms behind these are elusive require large-scale omics studies better understand possibly discover new therapeutic approaches cancer.

Language: Английский

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Antioncogenic potential of probiotics: Challenges and future prospective

Indian Journal of Microbiology Research, Journal Year: 2023, Volume and Issue: 10(1), P. 1 - 10

Published: May 1, 2023

Probiotics are beneficial microorganisms that have shown to possess numerous health benefits. Recently, there has been budding interests in the utilization of probiotics as a prospective weapon for cancer deterrence and management. The antioncogenic attributes were provided through various mechanisms such immune modulation, production anticancer compounds, regulation intestinal microbiota. current study shed light on probiotic strains explored their mechanisms. However, use prevention treatment also poses several challenges, including identification specific with most potent effects, optimal dosage duration treatment, hazards allied implementation live microorganisms. Additionally, heterogeneity types patients' microbiomes further complicate selection clinical applications. Hence, future should concentrate development alternative approaches microbial-derived components, genetically modified probiotics, synthetic biology overcome these challenges enhance potential probiotics.

Language: Английский

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Interleukins (Cytokines) as Biomarkers in Colorectal Cancer: Progression, Detection, and Monitoring

Journal of Clinical Medicine, Journal Year: 2023, Volume and Issue: 12(9), P. 3127 - 3127

Published: April 25, 2023

Cancer is the primary cause of death in economically developed countries and second leading developing countries. Colorectal cancer (CRC) third most common cancer-related deaths worldwide. Risk factors for CRC include obesity, a diet low fruits vegetables, physical inactivity, smoking. has poor prognosis, there critical need new diagnostic prognostic biomarkers to reduce related deaths. Recently, studies have focused more on molecular testing guide targeted treatments patients. The crucial feature activated immune cells production release growth cytokines that modulate inflammatory conditions tumor tissues. cytokine network valuable prognosis pathogenesis colorectal as they can aid cost-effective non-invasive detection cancer. A large number interleukins (IL) released by system at various stages act “biomarkers”. They play diverse functions cancer, IL-4, IL-6, IL-8, IL-11, IL-17A, IL-22, IL-23, IL-33, TNF, TGF-β, vascular endothelial factor (VEGF), which are pro-tumorigenic genes. However, an inadequate this area considering its correlation with profiles clinically useful diagnosing better understanding levels establish pathways entails interactions regulation their biochemical signaling healthy individuals. This review provides comprehensive summary some immunological CRC.

Language: Английский

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Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(14), P. 2018 - 2037

Published: April 12, 2024

Colorectal cancer (CRC) ranks among the most prevalent malignant tumors globally. Recent reports suggest that

Language: Английский

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Aberrant bowel movement frequencies coincide with increased microbe-derived blood metabolites associated with reduced organ function

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(7), P. 101646 - 101646

Published: July 1, 2024

Bowel movement frequency (BMF) directly impacts the gut microbiota and is linked to diseases like chronic kidney disease or dementia. In particular, prior work has shown that constipation associated with an ecosystem-wide switch from fiber fermentation short-chain fatty acid production more detrimental protein toxin production. Here, we analyze multi-omic data generally healthy adults see how BMF affects their molecular phenotypes, in a pre-disease context. Results show differential abundances of microbial genera, blood metabolites, variation lifestyle factors across categories. These differences relate inflammation, heart health, liver function, function. Causal mediation analysis indicates association between lower reduced function partially mediated by microbially derived 3-indoxyl sulfate (3-IS). This result, context, suggests accumulation microbiota-derived toxins abnormal precede organ damage may be drivers chronic, aging-related diseases.

Language: Английский

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