Gut-joint axis: Gut dysbiosis can contribute to the onset of rheumatoid arthritis via multiple pathways

Frontiers in Cellular and Infection Microbiology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 27, 2023

Rheumatoid Arthritis (RA) is an autoimmune disease characterized by loss of immune tolerance and chronic inflammation. It pathogenesis complex includes interaction between genetic environmental factors. Current evidence supports the hypothesis that gut dysbiosis may play role triggers arthritis in animals humans. Progress understanding microbiome RA. has been remarkable last decade. In vitro vivo experiments revealed could shape system cause persistent inflammatory responses. Furthermore, induce alterations intestinal permeability, which have found to predate onset. contrast, metabolites derived from microbiota immunomodulatory anti-inflammatory effect. However, precise underlying mechanisms induces development remain elusive. This review aimed highlight contribute The overall data showed RA multiple pathways, including barrier function, molecular mimicry, influences activation differentiation innate acquired cells, cross-talk microbiota-derived microenvironment. relative weight each these remains uncertain. Recent studies a substantial for pathway, especially butyrate, pathogenesis.

Language: Английский

---

Relationship between gut microbiota and rheumatoid arthritis: A bibliometric analysis

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 1, 2023

Introduction Rheumatoid arthritis (RA) is a multifactorial autoimmune disease. Recently, growing evidence demonstrates that gut microbiota (GM) plays an important role in RA. But so far, no bibliometric studies pertaining to GM RA have ever been published. This study attempts depict the knowledge framework this field from holistic and systematic perspective based on analysis. Methods Literature related involvement of was searched picked Web Science Core Collection (WOSCC) database. The annual output, cooperation, hotspots, research status development trend were analyzed by software (VOSviewer Bibliometricx). Results 255 original articles 204 reviews included can be retrieved WOSCC first published 2004 increased year since then. 2013 growth explosion point. China United States are countries with most contributions, Harvard University affiliation output. Frontiers Immunology (total citations = 603) journal publications fastest rate. eLife 1248). Scher, Jose U. Taneja, Veena productive cited authors. mainly distributed evidence, mechanism practical application participating through analysis keywords documents. There sufficient prove close relationship between RA, which lays foundation for field. extended two colorful tender branches exploration, made some achievements but still broad exploration space. ”metabolites“, ”metabolomics“, ”acid“, ”b cells“, ”balance“, ”treg ”probiotic supplementation“ appeared frequently, tells us its hotspots recent years. Discussion Taken together, these results provide data-based objective introduction giving readers valuable reference help guide future research.

Language: Английский

---

Efficacy and safety of dietary polyphenols in rheumatoid arthritis: A systematic review and meta-analysis of 47 randomized controlled trials

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: March 22, 2023

Objective To evaluate safety and efficacy of dietary polyphenols in the treatment rheumatoid arthritis (RA). Methods CNKI, Pubmed, Cochrane library, Embase were searched to collect randomized controlled trials (RCTs) RA. The databases from time their establishment November 8nd, 2022. After 2 reviewers independently screened literature, extracted data, assessed risk bias included studies, Meta-analysis was performed using RevMan5.4 software. Results A total 49 records (47 RCTs) finally included, involving 3852 participants 15 types (Cinnamon extract, Cranberry Crocus sativus L. Curcumin, Garlic Ginger Hesperidin, Olive oil, Pomegranate Puerarin, Quercetin, Resveratrol, Sesamin, Tea polyphenols, Total glucosides paeony). Cinnamon Sesamin only involve 1 RCT. RCTs. paeony Curcumin more than 3 These RCTs showed that these could improve disease activity score for 28 joints (DAS28), inflammation levels or oxidative stress addition did not increase adverse events. Conclusion Dietary may DAS28, reduce C-reactive protein (CRP) erythrocyte sedimentation rate (ESR), stress, etc. However, are needed verify modify polyphenols. Systematic review registration https://www.crd.york.ac.uk/prospero/ , identifier CRD42022315645.

Language: Английский

---

Role of the Gut Microbiota in Osteoarthritis, Rheumatoid Arthritis, and Spondylarthritis: An Update on the Gut–Joint Axis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3242 - 3242

Published: March 13, 2024

Dysregulation of the gut microbiota and their metabolites is involved in pathogenic process intestinal diseases, several pieces evidence within current literature have also highlighted a possible connection between unfolding inflammatory pathologies joints. This dysregulation defined as "gut-joint axis" based on joint-gut interaction. It widely recognized that produce variety compounds, including enzymes, short-chain fatty acids, metabolites. As consequence, these proinflammatory compounds bacteria produce, such lipopolysaccharide, move from "leaky gut" to bloodstream, thereby leading systemic inflammation which then reaches joints, with consequences osteoarthritis, rheumatoid arthritis, spondylarthritis. In this state-of-the-art research, authors describe connections dysbiosis Moreover, diagnostic tools, outcome measures, treatment options are elucidated. There accumulating proof suggesting play an important part not only immune-mediated, metabolic, neurological illnesses but According authors, future studies should concentrate developing innovative microbiota-targeted treatments effects joint pathology well organizing screening protocols predict onset disease dysbiosis.

Language: Английский

---

Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

Arthritis Research & Therapy, Journal Year: 2024, Volume and Issue: 26(1)

Published: Jan. 13, 2024

Abstract Background Patients with rheumatoid arthritis (RA) showed impaired immune tolerance characterized by reduced follicular regulatory T (Tfr) cells, and they also exhibited altered gut microbiotas their metabolites in RA. However, the association of mediated Tfr cells RA remains unclear. Methods Peripheral blood stool samples were collected from 32 new-onset patients 17 healthy controls (HCs) Second Hospital Shanxi Medical University between January 2022 June 2022. The peripheral was used to detect circulating (Treg), helper T(Th)17, Tfr, (Tfh) modified flow cytometry. analyze via 16S rDNA sequencing metabolomic profiling. We aimed characterize identified cell-mediated tolerance. Results demonstrated Treg associated disease activity autoantibodies. There significant differences two groups as results β diversity analysis ( P = 0.039) including 21 differential phylum genus levels. In which, Ruminococcus 2 autoantibodies RA, it potential biomarker [area under curve (AUC) 0.782, 95% confidence interval (CI) 0.636–0.929, 0.001]. Eleven participated four main pathways related Arachidonic acid might be (AUC 0.724, CI 0.595–0.909, 0.038), core metabolite positive six enriched , arachidonic involved biosynthesis unsaturated fatty pathway 3-methyldioxyindole tryptophan metabolism pathway. Conclusion breakdown implying possible mechanism pathogenesis perspective microecology-metabolism-immune.

Language: Английский

---

Extracellular polysaccharides from Sporidiobolus pararoseus alleviates rheumatoid through ameliorating gut barrier function and gut microbiota

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129436 - 129436

Published: Jan. 21, 2024

Language: Английский

---

Gut microbial metabolite targets HDAC3-FOXK1-interferon axis in fibroblast-like synoviocytes to ameliorate rheumatoid arthritis

Bone Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: May 23, 2024

Abstract Rheumatoid arthritis (RA) is an autoimmune disease. Early studies hold opinion that gut microbiota environmentally acquired and associated with RA susceptibility. However, accumulating evidence demonstrates genetics also shape the microbiota. It known some strains of inbred laboratory mice are highly susceptible to collagen-induced (CIA), while others resistant CIA. Here, we show transplantation fecal CIA-resistant C57BL/6J CIA-susceptible DBA/1J confer CIA resistance in mice. healthy human individuals have enriched B. fragilis than patients. Transplantation prevents We identify mainly produces propionate higher level propionate. Fibroblast-like synoviocytes (FLSs) activated undergo tumor-like transformation. Propionate disrupts HDAC3-FOXK1 interaction increase acetylation FOXK1, resulting reduced FOXK1 stability, blocked interferon signaling deactivation RA-FLSs. treat attenuates Moreover, a combination anti-TNF etanercept synergistically relieves These results suggest or could be alternative complementary approach current therapies.

Language: Английский

---

Overview of anti-inflammatory diets and their promising effects on non-communicable diseases

British Journal Of Nutrition, Journal Year: 2024, Volume and Issue: 132(7), P. 898 - 918

Published: Oct. 14, 2024

Abstract An anti-inflammatory diet is characterised by incorporating foods with potential properties, including fruits, vegetables, whole grains, nuts, legumes, spices, herbs and plant-based protein. Concurrently, pro-inflammatory red processed meat, refined carbohydrates saturated fats are limited. This article explores the effects of an on non-communicable diseases (NCD), concentrating underlying mechanisms that connect systemic chronic inflammation, dietary choices disease outcomes. Chronic inflammation a pivotal contributor to initiation progression NCD. review provides overview intricate pathways through which influences pathogenesis conditions obesity, type II diabetes mellitus, CVD, autoinflammatory diseases, cancer cognitive disorders. Through comprehensive synthesis existing research, we aim identify some bioactive compounds present in deemed anti-inflammatory, explore their capacity modulate inflammatory and, consequently, prevent or manage The findings demonstrated herein contribute understanding interplay between nutrition, paving way for future recommendations research regarding preventive therapeutic strategies.

Language: Английский

---

Exploring the significance of microbiota metabolites in rheumatoid arthritis: uncovering their contribution from disease development to biomarker potential

Apmis, Journal Year: 2024, Volume and Issue: 132(6), P. 382 - 415

Published: March 12, 2024

Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder characterized by chronic inflammation and joint destruction. Recent research has elucidated the intricate interplay between gut microbiota RA pathogenesis, underscoring role of microbiota‐derived metabolites as pivotal contributors to disease development progression. The human microbiota, comprising vast array microorganisms their metabolic byproducts, plays crucial in maintaining immune homeostasis. Dysbiosis this microbial community been linked numerous disorders, including RA. Microbiota‐derived metabolites, such short‐chain fatty acids (SCFAs), tryptophan derivatives, Trimethylamine‐N‐oxide (TMAO), bile acids, peptidoglycan, lipopolysaccharide (LPS), exhibit immunomodulatory properties that can either exacerbate or ameliorate Mechanistically, these influence cell differentiation, cytokine production, barrier integrity, collectively shaping milieu. This review highlights recent advances understanding crosstalk pathogenesis also discusses potential specific trigger suppress autoimmunity, shedding light on molecular interactions with cells signaling pathways. Additionally, explores translational aspects diagnostic prognostic tools Furthermore, challenges prospects translating findings into clinical practice are critically examined.

Language: Английский

---

Alterations of the intestinal microbiome and metabolome in women with rheumatoid arthritis

Clinical and Experimental Medicine, Journal Year: 2023, Volume and Issue: 23(8), P. 4695 - 4706

Published: Aug. 12, 2023

Language: Английский

---