Clinical Pharmacology & Therapeutics,
Journal Year:
2024,
Volume and Issue:
116(2), P. 295 - 303
Published: April 30, 2024
Chronic
hepatitis
B
(CHB)
remains
a
major
global
public
health
problem.
The
functional
cure
is
the
ideal
therapeutic
target
recommended
by
latest
guidelines,
and
pursuing
has
become
key
treatment
end
point
of
current
therapy
for
upcoming
clinical
trials.
In
this
review,
based
on
published
research
evidence,
we
analyzed
concept
connotation
cures
elaborated
benefits
in
detail.
Secondly,
have
summarized
various
potential
methods
achieving
cures,
especially
elaborating
progress
interferon-based
optimized
strategies
cures.
We
also
which
populations
can
achieve
conducted
detailed
analysis
relevant
virological
serological
markers
screening
advantage
predicting
achievement.
addition,
introduced
difficulties
that
may
be
encountered
pursuit
cure.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7651 - 7651
Published: April 21, 2023
Hepatitis
B
virus
(HBV)
is
a
major
cause
of
chronic
hepatitis,
liver
cirrhosis,
and
hepatocellular
carcinoma.
Despite
the
advent
vaccines
potent
antiviral
agents
able
to
suppress
viral
replication,
recovery
from
HBV
infection
still
an
extremely
difficult
goal
achieve.
Complex
interactions
between
host
are
responsible
for
persistence
risk
oncogenesis.
Through
multiple
pathways,
silence
both
innate
adaptive
immunological
responses
become
out
control.
Furthermore,
integration
genome
into
that
production
covalently
closed
circular
DNA
(cccDNA)
represent
reservoirs
account
eradication
infection.
An
adequate
knowledge
virus–host
interaction
mechanisms
hepatocarcinogenesis
necessary
development
functional
cures
The
purpose
this
review
is,
therefore,
analyze
how
concur
in
infection,
persistence,
oncogenesis
what
implications
therapeutic
perspectives
follow.
Medicinal Research Reviews,
Journal Year:
2024,
Volume and Issue:
44(5), P. 2015 - 2034
Published: March 25, 2024
Abstract
The
hepatitis
B
elimination
is
a
goal
proposed
by
the
WHO
to
be
achieved
2030
through
adoption
of
synergistic
measures
for
prevention
and
chronic
HBV
infection
treatment.
Complete
cure
characterized
from
body
treatment,
which
once
achieved,
will
enable
elimination.
This,
today,
has
been
scientific
challenge.
difficulty
in
achieving
complete
due
indefinite
maintenance
covalently
closed
episomal
circular
DNA
(cccDNA)
reservoir
persistence
an
insufficient
dysfunctional
immune
response
chronically
infected
patients.
Among
adopted
eliminate
B,
two
have
potential
directly
interfere
with
virus
cycle,
but
limited
effect
on
control.
These
are
conventional
vaccines—blocking
transmission
antiviral
therapy—inhibiting
replication.
Vaccines,
despite
their
effectiveness
protecting
against
horizontal
preventing
mother‐to‐child
vertical
transmission,
no
or
virus.
Treatment
antivirals
suppresses
viral
replication,
curative
effect,
as
it
action
cccDNA.
Therapeutic
vaccines
comprise
additional
approach
however,
they
only
modest
system,
enhancing
temporarily.
This
manuscript
aims
address
(1)
cccDNA
hepatocyte
nucleus
dysfunction
individuals
primary
factors
that
hampered
treatment
human
body;
(2)
limitations
therapy
therapeutic
vaccines,
strategies
control
B;
(3)
possibly
promising
approaches
B.
Pathogens,
Journal Year:
2023,
Volume and Issue:
12(9), P. 1146 - 1146
Published: Sept. 8, 2023
Hepatitis
B
virus
(HBV)
is
a
challenge
for
global
health
services,
affecting
millions
and
leading
thousands
to
end-stage
liver
disease
each
year.
This
comprehensive
review
explores
the
interactions
between
HBV
host,
examining
their
impact
on
clinical
outcomes.
infection
encompasses
spectrum
of
severity,
ranging
from
acute
hepatitis
chronic
B,
which
can
potentially
progress
cirrhosis
hepatocellular
carcinoma
(HCC).
Occult
(OBI),
characterized
by
low
DNA
levels
in
surface
antigen-negative
individuals,
reactivate
cause
B.
genotyping
has
revealed
unique
geographical
patterns
relationships
with
Moreover,
single
nucleotide
polymorphisms
(SNPs)
within
human
host
genome
have
been
linked
several
outcomes,
including
cirrhosis,
HCC,
OBI,
reactivation,
spontaneous
clearance.
The
immune
response
plays
key
role
controlling
eliminating
infected
cells
neutralizing
bloodstream.
Furthermore,
modulate
metabolic
pathways
involved
glucose
lipid
metabolism
bile
acid
absorption,
influencing
progression.
outcomes
correlate
three
viral
adaptation.
In
conclusion,
could
result
complex
HBV.
These
vary
among
populations
are
influenced
genotypes,
genetics,
environmental
factors,
lifestyle.
Understanding
degrees
adaptation
essential
developing
region-specific
control
prevention
measures.
Frontiers in Microbiology,
Journal Year:
2023,
Volume and Issue:
14
Published: Dec. 21, 2023
Hepatitis
B,
a
global
health
concern
caused
by
the
hepatitis
B
virus
(HBV),
infects
nearly
2
billion
individuals
worldwide,
as
reported
World
Health
Organization
(WHO).
HBV,
hepatotropic
DNA
virus,
predominantly
targets
and
replicates
within
hepatocytes.
Those
carrying
are
at
increased
risk
of
liver
cirrhosis
hepatocellular
carcinoma,
resulting
in
900,000
fatalities
annually.
The
HBV
X
protein
(HBx),
encoded
virus’s
open
reading
frame
x,
plays
key
role
its
virulence.
This
is
integral
to
viral
replication,
immune
modulation,
cancer
progression.
Despite
significance,
precise
molecular
mechanisms
underlying
HBx
remain
elusive.
review
investigates
protein’s
roles
interferon
signaling
regulation,
carcinoma
By
understanding
complex
interactions
between
host
mediated
HBx,
we
aim
establish
solid
foundation
for
future
research
development
HBx-targeted
therapeutics.
Chinese Medicine,
Journal Year:
2024,
Volume and Issue:
19(1)
Published: March 18, 2024
Abstract
Background
HBV
infection
can
result
in
severe
liver
diseases
and
is
one
of
the
primary
causes
cell
carcinoma-related
mortality.
Liuwei
Wuling
tablet
(LWWL)
a
traditional
Chinese
medicine
formula,
with
protecting
decreasing
enzyme
activity,
usually
used
to
treat
chronic
hepatitis
B
NAs
clinic.
However,
its
main
active
ingredients
mechanism
action
have
not
been
fully
investigated.
Hence,
we
aimed
screen
ingredient
effective
combinations
from
explore
anti-herpatitis
virus
activity
mechanism.
Methods
Analysis
screening
antiviral
components
LWWL
by
network
pharmacology,
luteolin
(Lut)
may
be
compound
significant
activity.
The
Lut
was
also
found
real-time
PCR
detection
western
blotting.
Meanwhile,
established
co-culture
model
investigate
Schisandrin
C
(SC),
Schisandra
chinensis
fructus
(the
sovereign
drug
LWWL).
Next,
HBV-infected
mice
were
tail
vein
injection
pAAV-HBV1.2
plasmid
administered
continuously
for
20
days.
And
their
capacity
evaluated
checking
serum
levels
HBsAg,
HBeAg,
DNA,
HBcAg.
Results
In
this
study,
conducted
pharmacology
analysis
on
LWWL,
through
vitro
experimental
validation
data
analysis,
that
possessed
obviously
anti-HBV
inhibiting
replication
downregulating
hepatocyte
nuclear
factor
4α
(HNF4α)
via
ERK
pathway.
Additionally,
system
proved
SC
promoted
activation
cGAS-STINIG
pathway
IFN-β
production
THP-1
cells
inhibit
HepG2.2.15
cells.
Moreover,
combination
shows
greater
effect
compared
or
alone
mice.
Conclusion
Taken
together,
our
study
suggests
potential
candidate
prevention
treatment
B.
Biomarker Research,
Journal Year:
2024,
Volume and Issue:
12(1)
Published: Aug. 15, 2024
Abstract
The
global
burden
of
hepatitis
B
virus
(HBV)
infection
remains
high,
with
chronic
(CHB)
patients
facing
a
significantly
increased
risk
developing
cirrhosis
and
hepatocellular
carcinoma
(HCC).
ultimate
objective
antiviral
therapy
is
to
achieve
sterilizing
cure
for
HBV.
This
necessitates
the
elimination
intrahepatic
covalently
closed
circular
DNA
(cccDNA)
complete
eradication
integrated
HBV
DNA.
review
aims
summarize
oncogenetic
role
integration
significance
clearing
in
cure.
It
specifically
focuses
on
molecular
mechanisms
through
which
leads
HCC,
including
modulation
expression
proto-oncogenes
tumor
suppressor
genes,
induction
chromosomal
instability,
truncated
mutant
proteins.
also
highlights
impact
reducing
preventing
HBV-related
HCC.
Additionally,
offers
insights
into
future
objectives
treatment
CHB.
Current
strategies
inhibition
include
mainly
therapies,
RNA
interference
gene
editing
technologies.
Overall,
deserves
further
investigation
can
potentially
serve
as
biomarker
CHB
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 2, 2024
Background
OASL
(Oligoadenylate
Synthetase-Like),
an
interferon-induced
protein
in
the
OAS
family,
plays
a
significant
role
anti-viral
response.
Studies
have
demonstrated
its
association
with
prognosis
of
certain
tumors.
However,
mechanism
through
which
affects
tumors
is
unclear.
A
systemic
pan-cancer
study
needs
to
be
illustrated.
Methods
Analysis
expression
across
33
was
conducted
utilizing
TCGA,
GTEx
and
CPTAC
databases.
COX
Log-Rank
regressions
were
employed
calculate
prognosis.
We
validated
impact
on
apoptosis,
migration,
invasion
pancreatic
cancer
cell
lines.
Moreover,
we
seven
algorithms
bulk
data
investigate
immune
infiltration
within
tumor
microenvironment
(TIME)
ultimately
at
single-cell
transcriptome
level.
Results
discovered
elevated
genetic
heterogeneity
tumors,
link
closely
Validation
experiments
PAAD
confirmed
these
findings.
Additionally,
regulates
checkpoint
ligand
such
as
programmed
death
1
(PD-L1),
IFN-γ/STAT1
IL-6/JAK/STAT3
pathways
cells.
Meanwhile,
macrophages
TIME.
By
mechanisms
could
cause
dysfunction
cytotoxic
T
lymphocytes
(CTLs)
Discussion
Multi-omics
analysis
reveals
prognostic
immunological
biomarker
pan-cancer.
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(1), P. 57 - 57
Published: Jan. 3, 2025
About
296
million
people
worldwide
are
living
with
chronic
hepatitis
B
viral
(HBV)
infection,
and
outcomes
to
end-stage
liver
diseases
potentiated
by
alcohol.
HBV
replicates
in
hepatocytes,
but
other
non-parenchymal
cells
can
sense
the
virus.
In
this
study,
we
aimed
investigate
regulatory
effects
of
macrophages
on
marker
interferon-stimulated
genes
(ISGs)
expressions
hepatocytes.
This
study
was
performed
HBV-replicating
HepG2.2.15
human
monocyte-derived
(MDMs).
We
found
that
exposure
an
acetaldehyde-generating
system
(AGS)
increased
RNA,
DNA,
cccDNA
suppressed
activation
ISGs,
APOBEC3G,
ISG15,
OAS1.
Supernatants
collected
from
IFNα-activated
MDMs
decreased
levels
induced
ISG
AGS-treated
untreated
HepG2.215
cells.
These
were
reversed
ethanol
mimicked
treatment
exosome
release
inhibitor
GW4869.
conclude
exosome-mediated
crosstalk
between
IFN-activated
hepatocytes
plays
a
protective
role
via
up-regulation
ISGs
suppression
replication.
However,
breaks
protection.