Biology,
Journal Year:
2023,
Volume and Issue:
12(7), P. 991 - 991
Published: July 12, 2023
Juvenile
Idiopathic
Arthritis
(JIA)
represents
the
most
common
chronic
pediatric
arthritis
in
Western
countries
and
a
leading
cause
of
disability
children.
Despite
recent
clinical
achievements,
patient
management
is
still
hindered
by
lack
diagnostic/prognostic
biomarkers
targeted
treatment
protocols.
MicroRNAs
(miRNAs)
are
short
non-coding
RNAs
playing
key
role
gene
regulation,
their
involvement
many
pathologies
has
been
widely
reported
literature.
In
decades,
miRNA’s
contribution
to
regulation
immune
system
pathogenesis
autoimmune
diseases
demonstrated.
Furthermore,
miRNAs
isolated
from
patients’
biological
samples
currently
under
investigation
for
potential
as
novel
biomarkers.
This
review
aims
provide
an
overview
state
art
on
miRNA
JIA.
The
literature
addressing
expression
different
types
JIA
patients
was
reviewed,
focusing
particular
application
responses
affected
joints
will
also
be
discussed
along
with
utility
markers
therapeutic
approaches.
information
value
investigators
field
rheumatology,
encouraging
further
research
increase
our
knowledge
miRNAs’
future
applications
Phytotherapy Research,
Journal Year:
2024,
Volume and Issue:
38(9), P. 4570 - 4591
Published: July 29, 2024
Abstract
miRNAs
are
tiny
noncoding
ribonucleotides
that
function
as
critical
regulators
of
gene‐expression
in
eukaryotes.
A
single
miRNA
may
be
involved
the
regulation
several
target
mRNAs
forming
complex
cellular
networks
to
regulate
diverse
aspects
development
an
organism.
The
deregulation
has
been
associated
with
human
diseases.
Therefore,
miRNA‐based
therapeutics
is
gaining
interest
pharmaceutical
industry
next‐generation
drugs
for
cure
many
Medicinal
plants
have
also
used
treatment
diseases
and
their
curative
potential
attributed
reserve
bioactive
metabolites.
role
phytometabolic
pathways
emerged
recent
past.
Experimental
studies
indicated
plant
encoded
secondary
phytometabolites
act
cross‐regulators
mammalian
transcripts
(like
cancer).
evidence
this
cross‐kingdom
gene
through
gathered
considerable
enthusiasm
scientific
field,
even
though
there
on‐going
debates
regarding
reproducibility
effectiveness
these
findings.
In
review,
we
provide
information
connect
medicinal
regulatory
properties
phytometabolites,
by
effects
on
regulating
downstream
metabolic
or
pathological
processes.
While
further
extensive
research
initiatives
good
clinical
required
prove
disapprove
findings,
understanding
regulations
will
important
implications
use
synthetic
artificial
effective
alternatives
providing
health
benefits.
Current Opinion in Rheumatology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
severe
autoimmune/inflammatory
disease.
Patients
with
juvenile
disease-onset
and
those
of
non-European
ancestry
are
most
severely
affected.
While
the
exact
pathophysiology
remains
unknown,
common
rare
gene
variants
in
context
environmental
exposure
epigenetic
alterations
involved.
This
manuscript
summarizes
current
understanding
genetic
contributors
to
SLE
risk,
manifestations
outcomes.
Biology,
Journal Year:
2023,
Volume and Issue:
12(7), P. 991 - 991
Published: July 12, 2023
Juvenile
Idiopathic
Arthritis
(JIA)
represents
the
most
common
chronic
pediatric
arthritis
in
Western
countries
and
a
leading
cause
of
disability
children.
Despite
recent
clinical
achievements,
patient
management
is
still
hindered
by
lack
diagnostic/prognostic
biomarkers
targeted
treatment
protocols.
MicroRNAs
(miRNAs)
are
short
non-coding
RNAs
playing
key
role
gene
regulation,
their
involvement
many
pathologies
has
been
widely
reported
literature.
In
decades,
miRNA’s
contribution
to
regulation
immune
system
pathogenesis
autoimmune
diseases
demonstrated.
Furthermore,
miRNAs
isolated
from
patients’
biological
samples
currently
under
investigation
for
potential
as
novel
biomarkers.
This
review
aims
provide
an
overview
state
art
on
miRNA
JIA.
The
literature
addressing
expression
different
types
JIA
patients
was
reviewed,
focusing
particular
application
responses
affected
joints
will
also
be
discussed
along
with
utility
markers
therapeutic
approaches.
information
value
investigators
field
rheumatology,
encouraging
further
research
increase
our
knowledge
miRNAs’
future
applications
