Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury DOI Creative Commons
Zeping Liu,

Chunyu Xiang,

Xu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below level or permanent loss function in severe cases. Dynamic spatiotemporal neuroinflammation vital neurological recovery, which collectively constituted by dynamic changes series inflammatory cells, including microglia, neutrophils, astrocytes, among others. Immunomodulatory nanomaterials readily improve therapeutic effects simultaneously overcome various drawbacks associated with treatment, such as off-target side bioactivity immune agents during circulation. In this review, we discuss role inflammation secondary injuries after SCI, elaborate on mechanism action effect existing treating summarize mechanism(s) whereby they regulate inflammation. Finally, challenges prospects using nanotechnology modulate immunotherapy are discussed provide new insights for future treatment. Deciphering intricate mechanisms SCI requires further in-depth studies. Therefore, continues represent formidable challenge.

Language: Английский

The acute spinal cord injury microenvironment and its impact on the homing of mesenchymal stem cells DOI
Jinyi Liu,

Longju Qi,

Shengzhe Bao

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 373, P. 114682 - 114682

Published: Jan. 9, 2024

Language: Английский

Citations

5
Interleukin-33 Knockout Promotes High Mobility Group Box 1 Release from Astrocytes by Acetylation Mediated by P300/CBP-Associated Factor in Experimental Autoimmune Encephalomyelitis DOI
Yifan Xiao,

Liyan Hao,

Xinyi Cao

et al.

Neuroscience Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Research Progress of Flavonoids in Spinal Cord Injury: Therapeutic Mechanisms and Drug Delivery Strategies DOI
Shizhe Li, Shutao Gao, Yukun Hu

et al.

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.

Language: Английский

Citations

0
Blockade of the ADAM8-Fra-1 complex attenuates neuroinflammation by suppressing the Map3k4/MAPKs axis after spinal cord injury DOI Creative Commons
Zhanyang Qian,

Rulin Li,

Tianyu Zhao

et al.

Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)

Published: May 16, 2024

Mechanical spinal cord injury (SCI) is a deteriorative neurological disorder, causing secondary neuroinflammation and neuropathy. ADAM8 thought to be an extracellular metalloproteinase, which regulates proteolysis cell adherence, but whether its intracellular region involved in regulating microglia after SCI unclear.

Language: Английский

Citations

2
High mobility group box 1 in the central nervous system: regeneration hidden beneath inflammation DOI Creative Commons
Hanki Kim, Bum‐Joon Kim, Seungyon Koh

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(1), P. 107 - 115

Published: April 3, 2024

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied diverse fields, including neurology neuroscience. extracellular space functions pro-inflammatory damage-associated molecular pattern, which proven to play an important role wide variety of central nervous system disorders such ischemic stroke, Alzheimer’s disease, frontotemporal dementia, Parkinson’s multiple sclerosis, epilepsy, traumatic brain injury. Several drugs that inhibit high-mobility glycyrrhizin, ethyl pyruvate, neutralizing anti-high-mobility antibodies, are commonly used target activity disorders. Although it is known for its detrimental inflammatory effect, also shown have beneficial pro-regenerative roles In this narrative review, we provide brief summary history research characterization downstream receptors, intracellular signaling pathways, how exerts repair-favoring general system, clues on differentiate from role. Research targeting may benefit differentiating between two rather than overall suppression 1.

Language: Английский

Citations

1
Dexborneol Amplifies Pregabalin’s Analgesic Effect in Mouse Models of Peripheral Nerve Injury and Incisional Pain DOI Creative Commons
Zhen Shen,

Yun-Dan Guo,

Ming-Ze Tang

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(7), P. 803 - 803

Published: July 2, 2024

Pregabalin is a medication primarily used in the treatment of neuropathic pain and anxiety disorders, owing to its gabapentinoid properties. monotherapy faces limitations due variable efficacy dose-dependent adverse reactions. In this study, we conducted comprehensive investigation into potentiation pregabalin’s analgesic effects by dexborneol, neuroprotective bicyclic monoterpenoid compound. We performed animal experiments where models were induced using two methods: peripheral nerve injury, involving axotomy ligation tibial common peroneal nerves, incisional through longitudinal incision hind paw, while employing multifaceted methodology that integrates behavioral pharmacology, molecular biology, neuromorphology, lipidomics delve mechanisms behind potentiation. Dexborneol was found enhance promoting transportation central nervous system, disrupting self-amplifying vicious cycles via reduction HMGB1 ATP release, exerting significant anti-oxidative modulation lipid metabolism. This combination therapy not only boosted property but also notably decreased side effects. Moreover, therapeutic cocktail exceeded basic relief, effectively reducing neuroinflammation glial cell activation—key factors contributing persistent chronic pain. study paves way for more tolerable effective options, highlighting potential dexborneol as an adjuvant pregabalin therapy.

Language: Английский

Citations

1
Pathological role of RAGE underlying progression of various diseases: its potential as biomarker and therapeutic target DOI

Saswati Sarkar

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Language: Английский

Citations

1
Evaluation on the antibacterial activity of glycyrrhizin against Pseudomonas plecoglossicida in ayu fish (Plecoglossus altivelis) DOI

Fan Tao,

Jia-Feng Cao,

Yanjun Liu

et al.

Aquaculture, Journal Year: 2024, Volume and Issue: 595, P. 741520 - 741520

Published: Aug. 28, 2024

Language: Английский

Citations

0
Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury DOI Creative Commons
Zeping Liu,

Chunyu Xiang,

Xu Zhao

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Dec. 19, 2024

Spinal cord injury (SCI) is a common clinical condition of the central nervous system that can lead to sensory and motor impairment below level or permanent loss function in severe cases. Dynamic spatiotemporal neuroinflammation vital neurological recovery, which collectively constituted by dynamic changes series inflammatory cells, including microglia, neutrophils, astrocytes, among others. Immunomodulatory nanomaterials readily improve therapeutic effects simultaneously overcome various drawbacks associated with treatment, such as off-target side bioactivity immune agents during circulation. In this review, we discuss role inflammation secondary injuries after SCI, elaborate on mechanism action effect existing treating summarize mechanism(s) whereby they regulate inflammation. Finally, challenges prospects using nanotechnology modulate immunotherapy are discussed provide new insights for future treatment. Deciphering intricate mechanisms SCI requires further in-depth studies. Therefore, continues represent formidable challenge.

Language: Английский

Citations

0