Design, Synthesis and Biological Evaluation of Naphthalimide‐Polyamine Conjugate as a Potential Anti‐Colorectal Cancer Agent DOI
Fujun Dai, Yue Cao,

Chenguang Zhu

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

ABSTRACT Colorectal cancer is the second most common cause of cancer‐related death worldwide, with a rising incidence, highlighting an urgent need for novel therapeutics. In this study, we developed several polyamine conjugates. Compound 6 ( C6 ) was selected as lead compound and evaluated anticancer activity in vitro vivo. experiments showed that inhibited cell proliferation, colony formation, migration, invasion colorectal cells while inducing apoptosis, pyroptosis, autophagosome formation. Genetic or pharmacological inhibition autophagy weakened ‐induced apoptosis gasdermin E (GSDME)‐dependent pyroptosis. Inactivation caspase 3 by AC‐DEVD‐CHO decreased levels N‐terminal GSDME induced . Furthermore, animal models exhibited suppressed tumor growth dissemination after treatment Taken together, our findings highlight potential drug against cancer.

Language: Английский

Research Progress of GSDMD in Tumors DOI

鹏伟 白

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(02), P. 2885 - 2891

Published: Jan. 1, 2024

Language: Английский

Citations

0
Bulk anda single-cell transcriptome profiling reveals the molecular characteristics of T cell-mediated tumor killing in pancreatic cancer DOI Creative Commons

Yinwei Dai,

Ya-ting Pan,

Danfeng Lin

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(5), P. e27216 - e27216

Published: Feb. 28, 2024

BackgroundDespite the potential of immune checkpoint blockade (ICB) as a promising treatment for Pancreatic adenocarcinoma (PAAD), there is still need to identify specific subgroups PAAD patients who may benefit more from ICB. T cell-mediated tumor killing (TTK) primary concept behind We explored subtypes according genes correlated with sensitivity TKK and unraveled their underlying associations immunotherapies.MethodsGenes that control responsiveness cell-induced destruction (GSTTK) were examined in PAAD, focusing on varying expression levels association survival results. Moreover, samples separated into two subsets using unsupervised clustering based GSTTK. Variability was evident microenvironment, genetic mutation, response immunotherapy among different groups. In end, we developed TRGscore, an innovative scoring system, investigated its clinical predictive significance determining immunotherapy.ResultsPatients categorized 2 clusters 52 GSTTKs, which showed prognostic relevance, revealing unique TTK patterns. Survival outcome, cell infiltration, responses, functional enrichment are also distinguished clusters. found CATSPER1 gene promotes progression through experiments. addition, TRGscore effectively predicted responses chemotherapeutics or overall survival.ConclusionsTTK exerted vital influence environment PAAD. A greater understanding TIME characteristics gained evaluation variations modes across types. It highlights performance cells provides direction improved approaches.

Language: Английский

Citations

0
Research progress on the effect of pyroptosis on the occurrence, development, invasion and metastasis of colorectal cancer DOI Open Access

Xu Wang,

Qi-Hang Yin,

Lin-Lu Wan

et al.

World Journal of Gastrointestinal Oncology, Journal Year: 2024, Volume and Issue: 16(8), P. 3410 - 3427

Published: Aug. 7, 2024

Pyroptosis is a type of programmed cell death mediated by gasdermines (GSDMs). The N-terminal domain GSDMs forms pores in the plasma membrane, causing membrane rupture and release contents, leading to an inflammatory response mediating pyrodeath. plays important role diseases malignant tumors. With further study pyroptosis, increasing number studies have shown that pyroptosis pathway can regulate tumor microenvironment antitumor immunity colorectal cancer closely related occurrence, development, treatment prognosis cancer. This review aimed explore molecular mechanism (CRC) provide ideas for clinical diagnosis CRC.

Language: Английский

Citations

0
The Role of Pyroptosis in the Progression and Targeted Therapeutic Approaches for Urological Malignancies DOI Creative Commons

Wenjie Cheng,

Wei Chen, Ruipeng Jia

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9567 - 9581

Published: Nov. 1, 2024

The prevalence of urological malignancies continues to pose a significant global health challenge, particularly due the poor prognosis associated with advanced stages these diseases. Consequently, there is an urgent need deepen our understanding molecular mechanisms governing development facilitate breakthroughs in diagnosis and treatment. Pyroptosis, novel specific form programmed cell death, plays crucial role regulating inflammatory responses, development, tissue homeostasis, stress responses. Recent research has revealed close association between pyroptosis malignancies. In this paper, we review pathogenesis recent advancements malignancies, elucidate involved its regulation, aim provide new directions for clinical management

Language: Английский

Citations

0
Design, Synthesis and Biological Evaluation of Naphthalimide‐Polyamine Conjugate as a Potential Anti‐Colorectal Cancer Agent DOI
Fujun Dai, Yue Cao,

Chenguang Zhu

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 5, 2024

ABSTRACT Colorectal cancer is the second most common cause of cancer‐related death worldwide, with a rising incidence, highlighting an urgent need for novel therapeutics. In this study, we developed several polyamine conjugates. Compound 6 ( C6 ) was selected as lead compound and evaluated anticancer activity in vitro vivo. experiments showed that inhibited cell proliferation, colony formation, migration, invasion colorectal cells while inducing apoptosis, pyroptosis, autophagosome formation. Genetic or pharmacological inhibition autophagy weakened ‐induced apoptosis gasdermin E (GSDME)‐dependent pyroptosis. Inactivation caspase 3 by AC‐DEVD‐CHO decreased levels N‐terminal GSDME induced . Furthermore, animal models exhibited suppressed tumor growth dissemination after treatment Taken together, our findings highlight potential drug against cancer.

Language: Английский

Citations

0