Liječnički vjesnik, Journal Year: 2022, Volume and Issue: 144(9-10)
Published: Oct. 13, 2022
SAŽETAK
Language: Английский
Medicine, Journal Year: 2024, Volume and Issue: 103(28), P. e38922 - e38922
Published: July 12, 2024
The coronavirus disease 2019 (COVID-19) pandemic has not only challenged global health systems but also spurred intense scientific inquiry into its pathophysiology. Among the multifaceted aspects of disease, coagulation abnormalities have emerged as a significant contributor to morbidity and mortality. From endothelial dysfunction dysregulated immune responses, various factors contribute hypercoagulable state seen in severe COVID-19 cases. dysregulation extends beyond traditional thromboembolic events, encompassing spectrum ranging from microvascular thrombosis disseminated intravascular (DIC). Endothelial injury induced by acute respiratory syndrome 2 (SARS-CoV-2) infection triggers cascade events involving platelet activation, factor consumption, fibrinolysis impairment. Moreover, virus direct effects on cells cytokine storm further exacerbate prothrombotic milieu. Unraveling this intricate web interactions between viral pathogenesis host responses is essential for elucidating novel therapeutic targets refining existing management strategies COVID-19-associated coagulopathy. In quest unravel complex interplay COVID-19, numerous clinical laboratory studies yielded invaluable insights potential biomarkers, prognostic indicators, avenues. Anticoagulation therapy cornerstone although optimal dosing regimens patient selection criteria remain subjects ongoing investigation. Additionally, innovative approaches such targeting specific components or modulating function hold promise future development.
Language: Английский
Citations
10
EClinicalMedicine, Journal Year: 2022, Volume and Issue: 55, P. 101745 - 101745
Published: Nov. 25, 2022
Language: Английский
Citations
21
Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 9
Published: May 19, 2022
Objective To determine whether gut microbiota, fatty metabolism and cytokines were associated with immune thrombocytopenia (ITP). Methods In total, 29 preliminarily diagnosed ITP patients 33 healthy volunteers enrolled. Fecal bacterial analyzed based on 16S rRNA sequencing. Plasma motabolites using flow cytometry liquid chromatography-mass spectrometry (LC-MS), respectively. Results Bacteroides , Phascolarctobacterium Lactobacillus enriched at the genus level in patients, while Ruminococcaceae UCG-002 Eubacterium coprostanoligeues Megamonas, Lachnospiraceae NC2004 depleted. At phylum level, relative abundance of Proteobacteria Chloroflexi increased Firmicutes Actinobacteria Firmicutes/Bacteroidetes ratio decreased. levels 5-hydroxyeicosatetraenoic acid (5-HETE), 6-trans-12-epi-leukotriene B4 (6t,12e-LTB 4 ), resolvin D2 (RvD 2 ) upregulated, stachydrine, dowicide A, dodecanoylcarnitine downregulated patients. Furthermore, RvD is positively correlated order Bacteroidetes VC2.1 Bac22 5-HETE Azospirillum 6t,12e-LTB Cupriavidus . addition, stachydrine family Planococcaceae A class MVP-15 WCHB1-41 interleukin-6 (IL-6) tumor necrosis factor-α (TNF-α) upregulated Conclusion Our study revealed a relationship between microbiota ITP. Gut may participate pathogenesis through affecting cytokine secretion, interfering metabolism.
Language: Английский
Citations
19
Life, Journal Year: 2024, Volume and Issue: 14(4), P. 460 - 460
Published: April 1, 2024
In severe cases, SARS-CoV-2 infection leads to respiratory failure. Although angiotensin-converting enzyme 2 (ACE2) receptors are not expressed in red blood cells, can interact with cells (RBCs) via several or auxiliary membrane proteins. Recent data show that viral causes significant damage the RBCs, altering their morphology, deformability, and aggregability. Loss of RBC deformability and/or increased aggregability favors development thrombotic processes microcirculation, as has been described occur COVID-19 patients. addition, many patients also develop systemic endotheliitis associated generalized coagulopathy. This manifests itself clinically obstructive microthrombi area medium smallest vessels, which affect all internal organs. It is thought such changes RBCs may contribute microangiopathy/microthrombosis result impaired capillary flow tissue oxygenation.
Language: Английский
Citations
4
Research and Practice in Thrombosis and Haemostasis, Journal Year: 2025, Volume and Issue: 9(2), P. 102725 - 102725
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Clinical Investigation, Journal Year: 2025, Volume and Issue: 135(6)
Published: March 16, 2025
Early antibody therapy can prevent severe SARS-CoV-2 infection (COVID-19). However, the effectiveness of COVID-19 convalescent plasma (CCP) in treating remains inconclusive. To test a hypothesis that some CCP units are associated with coagulopathy hazard disease offsets its benefits, we tracked 304 administered to 414 hospitalized patients assess their association onset unfavorable post-transfusion D-dimer trends. recipients increasing or persistently elevated trajectories after transfusion experienced higher mortality than those whose levels were low decreasing transfusion. Within donor-recipient network, high skewed toward minority units. In vitro assays, from "higher-risk" had cross-reactivity spike protein human seasonal betacoronavirus OC43. "Higher-risk" also mediated greater Fcγ receptor IIa signaling against cells expressing compared "lower-risk" This study finds activation coagulation pathways during is specific profiles and supports potential mechanism immune complex–activated coagulopathy.
Language: Английский
Citations
0
Frontiers in Microbiology, Journal Year: 2022, Volume and Issue: 13
Published: Aug. 5, 2022
COVID-19 disease is caused by SARS-CoV-2. Hyper-inflammation mediated proinflammatory cytokines humans’ primary etiology of SARS-CoV-2 infection. Kochiae Fructus widely used in China as traditional Chinese medicine (TCM) to treat inflammatory diseases. Due its anti-inflammatory properties, we hypothesized that would be a promising therapeutic agent for COVID-19. The active phytomolecules, targets, and molecular pathways treating have not been explored yet. Network pharmacology analysis was performed determine the Fructus. phytomolecules were retrieved from Traditional Medicine Systems Pharmacology (TCMSP) database, their potential targets predicted with SwissTargetPrediction webserver. COVID-19-related recovered GeneCards database. Intersecting determined VENNY tool. Protein-protein interaction (PPI) Molecular Complex Detection (MCODE) network analyses constructed using Cytoscape software. Using DAVID tool, gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment on intersecting targets. AutoDock Vina (version 1.2.0.) docking analysis. Six 165 1,745 34 identified. 13 anti-COVID-19 core three key (Oleanolic acid, 9E,12Z-octadecadienoic 11,14-eicosadienoic acid). Three (pathways cancer, TNF signaling pathway, lipid atherosclerosis) top six (IL-6, PPARG, MAPK3, PTGS2, ICAM1, MAPK1) involved treatment revealed had regulatory effect identified Hence, these findings offer foundation developing drugs based
Language: Английский
Citations
15
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: March 2, 2023
Background Several viral and bacterial infections, including COVID-19, may lead to both thrombotic hemorrhagic complications. Previously, it has been demonstrated an “ in vitro ” pathogenic effect of “antiphospholipid” antibodies (aPLs), which are able activate a proinflammatory procoagulant phenotype monocytes, endothelial cells platelets. This study analyzed the occurrence aPL IgG patients with acute ischemic stroke (AIS) during evaluating Ig fractions from these on signaling functional activation Materials methods Sera 10 AIS non-COVID-19 patients, 20 COVID-19 30 healthy donors (HD) were for anti-cardiolipin, anti-β2-GPI, anti-phosphatidylserine/prothrombin anti-vimentin/CL by ELISA. Platelets incubated or polyclonal anti-β2-GPI phospho-ERK phospho-p38 western blot. Platelet secretion ATP release dosage was also evaluated. Results We presence aPLs sera COVID-19. Treatment induced significant increase expression. In same vein, platelet supported adenyl nucleotides fractions. Conclusions demonstrates subgroup who presented AIS, suggesting role mechanisms contributing hypercoagulable state patients. Detecting as serological marker check monitor contribute improve risk stratification thromboembolic manifestations
Language: Английский
Citations
8
Journal of Clinical Immunology, Journal Year: 2023, Volume and Issue: 43(5), P. 882 - 893
Published: March 21, 2023
Following a severe COVID-19 infection, proportion of individuals develop prolonged symptoms. We investigated the immunological dysfunction that underlies persistence symptoms months after resolution acute COVID-19.We analyzed cytokines, cell phenotypes, SARS-CoV-2 spike-specific and neutralizing antibodies, whole blood gene expression profiles in convalescent patients 1, 3, 6 following hospital discharge.We observed persistent abnormalities until month marked by (i) high serum levels monocyte/macrophage endothelial activation markers, chemotaxis, hematopoietic cytokines; (ii) frequency central memory CD4+ effector CD8+ T cells; (iii) decrease anti-SARS-CoV-2 spike antibodies; (iv) an upregulation genes related to platelet, neutrophil activation, erythrocytes, myeloid differentiation, RUNX1 signaling. identified "core signature" associated with history thrombotic events, set involved hematopoiesis, coagulation.The lack restoration normal profile up follow-up, even asymptomatic who experienced COVID-19, signals need carefully extend their clinical follow-up propose preventive measures.
Language: Английский
Citations
7
Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 3, 2024
Abstract Since the reports of first cases COVID-19, in less than 5 years, a huge number documents regarding that disease and coronavirus (SARS-CoV-2), responsible for infection, have been published. The tremendous scientific covers many topics on different issues directly related to COVID-19/SARS-CoV-2. articles—including reviews—reporting adverse/side effects approved COVID-19 vaccines is considerable. A wide range reported humans after vaccination: thrombotic events/thrombocytopenia, myocarditis/pericarditis, cutaneous reactions, immune-mediated effects, psychiatric adverse events, systemic lupus erythematosus, reproductive toxicity, other miscellaneous effects. In contrast, information nonclinical studies conducted assess potential toxicity/adverse laboratory animals, comparatively very scarce. present review was aimed at revising literature animals toxic/adverse vaccines. addition, investigations those specific toxicology journals with highest impact factors examined one by one. results indicate most nonclinical/experimental adverse/toxic and/or candidates showed—in general terms—a good safety profile. Only some animal were certain found. However, rather surprising result has limited available (in databases PubMed Scopus) performed companies largest manufacturers mRNA world. It assumed these conducted. they not published journals, which does allow judgment international community, including toxicologists.
Language: Английский
Citations
2