The role of lipid metabolic reprogramming in tumor microenvironment

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1774 - 1808

Published: Jan. 1, 2023

Metabolic reprogramming is one of the most important hallmarks malignant tumors.Specifically, lipid metabolic has marked impacts on cancer progression and therapeutic response by remodeling tumor microenvironment (TME).In past few decades, immunotherapy revolutionized treatment landscape for advanced cancers.Lipid plays pivotal role in regulating immune to immunotherapy.Here, we systematically reviewed characteristics, mechanism, cells TME, appraised effects various cell death modes (specifically ferroptosis) metabolism, summarized antitumor therapies targeting metabolism.Overall, profound microenvironment; therefore, may lead development innovative clinical applications including sensitizing immunotherapy.

Language: Английский

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Advances in understanding the role of squalene epoxidase in cancer prognosis and resistance

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 27, 2025

Language: Английский

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SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer

Cancer Letters, Journal Year: 2025, Volume and Issue: 616, P. 217586 - 217586

Published: Feb. 26, 2025

Language: Английский

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The role of lipid metabolism in tumor immune microenvironment and potential therapeutic strategies

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: Sept. 12, 2022

Aberrant lipid metabolism is nonnegligible for tumor cells to adapt the microenvironment (TME). It plays a significant role in amount and function of immune cells, including tumor-associated macrophages, T dendritic marrow-derived suppressor cells. well-known that response TME suppressed closely involved this process. Immunotherapy, containing anti-PD1/PDL1 therapy adoptive cell therapy, crucial clinical cancer therapeutic strategy nowadays, but they display low-sensibility certain cancers. In review, we mainly discussed importance formation immunosuppressive TME, explored effectiveness sensitivity immunotherapy treatment by regulating metabolism.

Language: Английский

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Crosstalk between cholesterol metabolism and psoriatic inflammation

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 10, 2023

Psoriasis is a chronic autoinflammatory skin disease associated with multiple comorbidities, prevalence ranging from 2 to 3% in the general population. Decades of preclinical and clinical studies have revealed that alterations cholesterol lipid metabolism are strongly psoriasis. Cytokines (tumor necrosis factor-α (TNF-α), interleukin (IL)-17), which important pathogenesis psoriasis, been shown affect metabolism. Cholesterol metabolites metabolic enzymes, on other hand, influence not only biofunction keratinocytes (a primary type cell epidermis) but also immune response inflammation. However, relationship between psoriasis has thoroughly reviewed. This review mainly focuses disturbances their crosstalk psoriatic

Language: Английский

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Lipid Metabolism as a Potential Target of Liver Cancer

Journal of Hepatocellular Carcinoma, Journal Year: 2024, Volume and Issue: Volume 11, P. 327 - 346

Published: Feb. 1, 2024

Abstract: Hepatocellular carcinoma (HCC) stands as a severe malignant tumor with profound impact on overall health, often accompanied by an unfavorable prognosis. Despite some advancements in the diagnosis and treatment of this disease, improving prognosis HCC remains formidable challenge. It is noteworthy that lipid metabolism plays pivotal role onset, development, progression cells. Existing research indicates potential application targeting HCC. This review aims to thoroughly explore alterations HCC, offering detailed account advantages associated innovative therapeutic strategies metabolism. Targeting holds promise for potentially enhancing Keywords: cholesterol, fatty acid, hepatocellular carcinoma, uptake, catabolism, synthesis

Language: Английский

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Squalene Epoxidase: Its Regulations and Links with Cancers

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3874 - 3874

Published: March 30, 2024

Squalene epoxidase (SQLE) is a key enzyme in the mevalonate–cholesterol pathway that plays critical role cellular physiological processes. It converts squalene to 2,3-epoxysqualene and catalyzes first oxygenation step pathway. Recently, intensive efforts have been made extend current knowledge of SQLE cancers through functional mechanistic studies. However, underlying mechanisms not fully elucidated yet. In this review, we retrospected as rate-limiting pathway, while shedding light on its potential diagnostic prognostic marker, revealed therapeutic values cancers. We showed regulated at different levels involved crosstalk with iron-dependent cell death. Particularly, systemically reviewed research findings Finally, discussed implications inhibitors summarized their clinical values. Overall, review multifaceted involve present vivid panorama

Language: Английский

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Pancreatic ductal adenocarcinoma cells reshape the immune microenvironment: Molecular mechanisms and therapeutic targets

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189183 - 189183

Published: Sept. 19, 2024

Language: Английский

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Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-L1 treatment

Cancer Drug Resistance, Journal Year: 2023, Volume and Issue: 6(3), P. 611 - 41

Published: Sept. 4, 2023

The development of immune checkpoint blockade (ICB) therapies has been instrumental in advancing the field immunotherapy. Despite prominence these treatments, many patients exhibit primary or acquired resistance, rendering them ineffective. For example, anti-PD-1/PD-L1 treatments are widely utilized across a range cancer indications, but response rate is only 10%-30%. As such, it necessary for researchers to identify targets and develop drugs that can be used combination with existing ICB overcome resistance. intersection cancer, metabolism, system gained considerable traction recent years as way comprehensively study mechanisms drive oncogenesis, evasion, immunotherapy result, new research continuously emerging support targeting metabolic pathways an adjuvant boost patient Due plethora studies highlighting this notion, review will integrate relevant articles demonstrate how tumor-derived alterations energy, amino acid, lipid metabolism dysregulate anti-tumor responses resistance therapy.

Language: Английский

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Targeting squalene epoxidase in the treatment of metabolic-related diseases: current research and future directions

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e18522 - e18522

Published: Nov. 22, 2024

Metabolic-related diseases are chronic caused by multiple factors, such as genetics and the environment. These difficult to cure seriously affect human health. Squalene epoxidase (SQLE), second rate-limiting enzyme in cholesterol synthesis, plays an important role synthesis alters gut microbiota tumor immunity. Research has shown that SQLE is expressed many tissues organs involved occurrence development of various metabolic-related diseases, cancer, nonalcoholic fatty liver disease, diabetes mellitus, obesity. inhibitors, terbinafine, NB598, natural compounds, their derivatives, can effectively ameliorate fungal infections, cancer. In this review, we provide overview recent research progress on diseases. Further regulation expression highly for developing drugs treatment with good pharmacological activity.

Language: Английский

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