Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 26, 2023
Abstract
Background:
Older
adults
are
at
increased
risk
of
severe
COVID19
infection.
In
this
study
we
assessed
the
response
to
vaccination
and
infection
rates
among
nursing
homes
(NH)
assisted-living
care
home
(ALCH)
residents.
Methods:
The
was
conducted
between
August
2021
January
2022,
after
widespread
population
with
third
dose
Pfizer-BioNtech
mRNA
COVID-19
vaccine
in
Israel.
Three
groups
were
addressed:
hospitalized
older
patients;
NH
ALCH
Demographic
data,
serology
(anti-spike
IgG
antibodies)
PCR
test
results
obtained
assess
dynamics
antibody
titers
its
correlation
rates.
Results:
Two-hundred
eighty-five
individuals
evaluated;
92
100
residents
93
latter
two
surveys
three
months
apart.
Hospitalized
patients
younger
than
(mean
age
80.4±8
versus
82.6±8
83.6±5,
respectively,
p
=0.01),
had
more
comorbidities
(
=0.003).
degree
decline
level
overtime
similar
Infection
higher
[35/90
(39%)
11/100
(11%),
<0.001].
Antibody
lower
those
infected
[2113
(1271-3512)
Au/ml
4113
(3364-5029)
Au/ml,
Adjusted
analysis
showed
that
residence,
but
not
levels,
significantly
associated
Conclusion:
Among
adults,
inversely
correlated
level.
However,
only
residence
infection,
suggesting
other
factors
such
as
crowding
considerably
contribute
BMC Geriatrics,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Feb. 15, 2024
Abstract
Background
Older
adults
are
at
increased
risk
of
severe
SARS-CoV-2
infection.
In
this
study
we
assessed
the
response
to
COVID-19
vaccination
and
infection
rates
among
nursing
homes
(NH)
assisted-living
care
home
(ALCH)
residents.
Methods
The
was
conducted
between
August
2021
January
2022,
after
widespread
population
with
third
dose
Pfizer-BioNtech
mRNA
vaccine
in
Israel.
Three
groups
were
addressed:
hospitalized
older
patients;
NH
ALCH
Demographic
data,
serology
(anti-spike
IgG
antibodies)
PCR
test
results
obtained
assess
dynamics
antibody
titers
its
correlation
rates.
Results
Two-hundred
eighty-five
individuals
evaluated;
92
100
residents
93
latter
two
surveys
three
months
apart.
Hospitalized
patients
younger
than
(mean
age
80.4
±
8
versus
82.6
83.6
5,
respectively,
p
=
0.01),
had
more
comorbidities
(
0.003).
degree
decline
level
overtime
similar
Infection
higher
[35/91
(38.4%)
11/100
(11%),
<
0.001].
Antibody
lower
those
infected
[2113
(1271–3512)
Au/ml
4113
(3364–5029)
Au/ml,
Adjusted
analysis
showed
that
residence,
but
not
levels,
significantly
associated
Conclusion
Among
adults,
inversely
correlated
level.
However,
only
residence
infection,
suggesting
other
factors
such
as
crowding
considerably
contribute
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 8, 2024
Introduction
The
study
investigation
examined
the
immune
response
to
Janssen
Ad26.COV2.S
COVID-19
vaccine
within
a
Ugandan
cohort,
specifically
targeting
antibodies
directed
against
spike
(S)
and
nucleocapsid
(N)
proteins.
We
aimed
examine
durability
robustness
of
induced
antibody
while
also
assessing
occurrences
breakthrough
infections
previous
anti-Spike
seropositivity
SARS-CoV-2.
Methods
included
319
specimens
collected
over
12
months
from
60
vaccinees
aged
18
64.
Binding
were
quantified
using
validated
ELISA
method
measure
SARS-CoV-2-specific
IgG,
IgM,
IgA
levels
S
N
Results
results
showed
that
baseline
for
S-IgG
was
high
at
67%,
increasing
98%
by
day
14
consistently
stayed
above
95%
up
months.
However,
S-IgM
responses
remained
suboptimal.
A
raised
S-IgA
rate
seen
doubled
40%
86%
just
two
weeks
following
initial
dose,
indicating
sustained
robust
peripheral
immunity.
An
increase
in
N-IgG
nine
post-vaccination
suggested
eight
cases.
Baseline
cross-reactivity
influenced
spike-directed
responses,
with
individuals
harbouring
showing
notably
higher
responses.
Discussion
Robust
long
lasting
infection-induced
observed,
significant
implications
regions
where
administering
subsequent
doses
poses
logistical
challenges.
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
Abstract
Background
While
correlates
of
protection
against
symptomatic
and
severe
breakthrough
SARS-CoV-2
infections
are
well
characterized,
virus
transmission
incompletely
understood.
Methods
We
studied
a
Croatian
cohort
individuals
with
documented
household
exposure
to
in
December
2022.
Sera
were
acquired
prior
symptom
onset,
at
the
time
COVID-19
diagnosis
index
cases,
comprehensively
analyzed
for
transmission.
monitored
participants
14
days
tested
them
PCR
end
observation
period
identify
any
transmission,
including
asymptomatic
ones.
Interpretation
Out
nearly
200
serological
parameters,
22
features
significantly
different
between
infected
uninfected
participants.
Titers
variant-specific
neutralizing
antibody
showed
biggest
difference
higher
subgroup.
Some
strong
IgM
responses
spike
antigen
robust
neutralization
titers
as
well.
Since
is
likely
an
indication
recent
antigenic
exposure,
data
reanalyzed
by
excluding
such
values.
This
refined
analysis
complete
segregation
into
groups
low
high
titers.
Therefore,
our
indicate
that
intense
contacts
among
members.
Funding
research
was
funded
Impulse
Networking
fund
Helmholtz
Association
through
grant
PIE-0008
LCS
VH-NG-19-28
YCB
Deutsche
Forschungsgemeinschaft
(DFG,
German
Research
Foundation)
under
Germany’s
Excellence
Strategy
-
EXC
2155
project
number
390874280
LCS.
BL
MH
received
funding
within
RESPINOW
from
Federal
Ministry
Education
031L0298A.
Context
Evidence
before
this
study
Pre-existing
immunity
SARS-CoV-2,
whether
or
vaccinations,
has
been
shown
primarily
protect
disease
rather
than
preventing
infection
altogether.
Many
current
studies
examining
phenomenon
focus
on
cohorts
occurring
certain
after
their
last
vaccination.
However,
these
often
lack
precise
information
about
when
status
immediately
infection.
Added
value
Unlike
other
studies,
we
focused
confirmed
SARS-CoV-2-positive
member.
Serum
samples
collected
coinciding
cases.
various
serum
assess
ability
not
only
but
also
Our
findings
revealed
who
remained
had
concentrations
antibodies
compared
those
became
infected.
Implications
available
evidence
finding
suggests
serve
correlate
could
inform
booster
strategies
based
fixed
timeline
levels
dropping
below
specific
threshold.
due
limited
sample
size
study,
larger
needed
confirm
results
establish
exact
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 26, 2023
Abstract
Background:
Older
adults
are
at
increased
risk
of
severe
COVID19
infection.
In
this
study
we
assessed
the
response
to
vaccination
and
infection
rates
among
nursing
homes
(NH)
assisted-living
care
home
(ALCH)
residents.
Methods:
The
was
conducted
between
August
2021
January
2022,
after
widespread
population
with
third
dose
Pfizer-BioNtech
mRNA
COVID-19
vaccine
in
Israel.
Three
groups
were
addressed:
hospitalized
older
patients;
NH
ALCH
Demographic
data,
serology
(anti-spike
IgG
antibodies)
PCR
test
results
obtained
assess
dynamics
antibody
titers
its
correlation
rates.
Results:
Two-hundred
eighty-five
individuals
evaluated;
92
100
residents
93
latter
two
surveys
three
months
apart.
Hospitalized
patients
younger
than
(mean
age
80.4±8
versus
82.6±8
83.6±5,
respectively,
p
=0.01),
had
more
comorbidities
(
=0.003).
degree
decline
level
overtime
similar
Infection
higher
[35/90
(39%)
11/100
(11%),
<0.001].
Antibody
lower
those
infected
[2113
(1271-3512)
Au/ml
4113
(3364-5029)
Au/ml,
Adjusted
analysis
showed
that
residence,
but
not
levels,
significantly
associated
Conclusion:
Among
adults,
inversely
correlated
level.
However,
only
residence
infection,
suggesting
other
factors
such
as
crowding
considerably
contribute
