The Potential of Superoxide Dismutase-Rich Tetraselmis chuii as a Promoter of Cellular Health

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1693 - 1693

Published: Feb. 16, 2025

Tetraselmis chuii (T. chuii) is a green, marine, eukaryotic, microalgae that was authorized in the European Union (EU) as novel food for human consumption 2014, and supplement 2017. This narrative review will provide an overview of preclinical clinical trials assessing efficacy T. chuii-derived ingredient, characterized by high superoxide dismutase (SOD) activity (SOD-rich chuii), to improve various aspects cellular health. Collectively, results from vitro, more importantly vivo research, support SOD-rich potential promoter Principally, ingredient appears function indirect antioxidant boosting intracellular systems. Moreover, it can positively modulate inflammatory status up-regulating anti-inflammatory down-regulating pro-inflammatory cytokines factors. In addition, promote health though protecting DNA damage, immune function, strengthening cell structure integrity, modulating signaling pathways. There also some evidence suggest may mitochondrial through up-regulation genes linked biogenesis ATP synthesis. From conducted date, transcriptional activation nuclear factor erythroid 2-related 2 (NRF2) sirtuin 1 (SIRT1) appear be important mediating effects on These exciting preliminary observations represent natural blue with enhance

Language: Английский

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Oxidative stress induced by combined glyphosate and TBBPA exposure promotes gill autophagy and inflammation via the PI3K/AKT/mTOR pathway

Fish & Shellfish Immunology, Journal Year: 2025, Volume and Issue: unknown, P. 110190 - 110190

Published: Feb. 1, 2025

Language: Английский

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Cytokine Signaling in Diabetic Neuropathy: A Key Player in Peripheral Nerve Damage

Biomedicines, Journal Year: 2025, Volume and Issue: 13(3), P. 589 - 589

Published: Feb. 28, 2025

Diabetic peripheral neuropathy (DPN) is a debilitating complication of diabetes mellitus, characterized by progressive nerve damage driven chronic hyperglycemia and systemic inflammation. The pathophysiology DPN significantly influenced pro-inflammatory cytokines, such as IL-1β, IL-6, TNF-α. These cytokines promote oxidative stress, vascular dysfunction, neuronal degeneration activating important signaling pathways including NF-κB MAPK. While IL-6 promotes microenvironment, increasing neuropathic pain, TNF-α IL-1β worsen Schwann cell failure compromising axonal support causing demyelination. Immune infiltration TLR activation increase the inflammatory cascade in DPN, resulting persistent neuroinflammatory state that sustains injury. main characteristics are degeneration, decreased neurotrophic support, which weaken transmission susceptibility to damage. Advanced glycation end-products, TNF-α, CXCL10 examples biomarkers may be used for early diagnosis disease progression monitoring. Additionally, crucial molecular targets have been found using proteomic transcriptome techniques, enabling precision medicine treatment DPN. This review emphasizes importance cytokine pathogenesis how cytokine-targeted treatments might reduce inflammation, restore function, improve clinical outcomes diabetic patients.

Language: Английский

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NLRP3 inflammasome and NLRP3-related autoinflammatory diseases: From cryopyrin function to targeted therapies

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 6, 2022

The NLRP3 inflammasome is one of the NOD-like receptor family members with most functional characterization and acts as a key player in innate immune system, participating several physiological processes including, among others, modulation system response coordination host defences. Activation crucial signaling mechanism that promotes both an acute chronic inflammatory response, which can accelerate production pro-inflammatory cytokines, mainly Interleukin (IL)-1β IL-18, leading to exacerbated network. Cryopyrin associated periodic syndrome (CAPS) rare inherited autoinflammatory disorder, clinically characterized by cutaneous systemic, musculoskeletal, central nervous inflammation. Gain-of-function mutations gene are causative signs symptoms CAPS patients, abnormal activation inflammasome, resulting inappropriate release IL-1β gasdermin-D-dependent pyroptosis, has been demonstrated vitro ex vivo studies. During recent years, two new hereditary NLRP3-related disorders have described, deafness autosomal dominant 34 (DFN34) keratitis fugax hereditaria (KFH), exclusive cochlear- anterior eye- restricted autoinflammation, respectively, caused gene, thus expanding clinical genetic spectrum NLRP3-associated diseases. Several mechanisms involved control regulation identified researchers took advantage this develop novel target therapies significant improvement This review provides broad overview biology particular emphasis on CAPS, whose clinical, genetic, therapeutic aspects will be explored depth. latest evidence "new" diseases, DFN34 KFH, also described.

Language: Английский

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“Outside-to-inside,” “inside-to-outside,” and “intrinsic” endogenous pathogenic mechanisms in atopic dermatitis: keratinocytes as the key functional cells involved in both permeability barrier dysfunction and immunological alterations

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 11, 2023

Permeability barrier disruption has been shown to induce immunological alterations (i.e., an "outside-to-inside" pathogenic mechanism). Conversely, several inflammatory and mechanisms reportedly interrupt permeability homeostasis "inside-to-outside" It is now widely recognized that of even a single molecule in keratinocytes can lead not only dysfunction but also alterations. Such simultaneous, bidirectional functional change by herein named "intrinsic" mechanism. Molecules and/or pathways involved this mechanism could be important as factors disease pathogenesis potential therapeutic targets for cutaneous diseases, such atopic dermatitis, psoriasis, prurigo nodularis. Elevation skin surface pH following abrogation comprises one the key phenomena Not type 2 cytokines (e.g., IL-4, IL-13, IL-31) 1 (e.g. IFN-γ), 3 IL-17, IL-22) well other histamine) disrupt are all considered part Finally, examples molecules relevant include keratin 1, filaggrin, peroxisome proliferator-activated receptor-α (PPARα).

Language: Английский

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Investigating the Potential Mechanisms and Therapeutic Targets of Inflammatory Cytokines in Post-stroke Depression

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(1), P. 132 - 147

Published: Aug. 17, 2023

Language: Английский

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Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of interleukin-18 levels on postherpetic neuralgia risk

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: May 25, 2023

Postherpetic neuralgia (PHN) is a debilitating complication of herpes zoster, characterized by persistent neuropathic pain that significantly impairs patients' quality life. Identifying factors determine PHN susceptibility crucial for its management. Interleukin-18 (IL-18), pro-inflammatory cytokine implicated in chronic pain, may play critical role development.In this study, we conducted bidirectional two-sample Mendelian randomization (MR) analyses to assess genetic relationships and potential causal associations between IL-18 protein levels increasing risk, utilizing genome-wide association study (GWAS) datasets on these traits. Two obtained from the EMBL's European Bioinformatics Institute database which contained 21,758 individuals with 13,102,515 SNPs Complete GWAS summary data 3,394 5,270,646 SNPs. The dataset FinnGen biobank had 195,191 16,380,406 SNPs.Our findings two different suggest correlation genetically predicted elevations an increased PHN.(IVW, OR 95% CI: 2.26, 1.07 4.78; p = 0.03 2.15, 1.10 4.19; =0.03, respectively), potentially indicating effect risk. However, did not detect any liability risk levels.These new insights into identifying at developing aid development novel prevention treatment approaches PHN.

Language: Английский

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Inflammasome activation in patients with Kaposi sarcoma herpesvirus (KSHV)-associated disorders

Blood, Journal Year: 2024, Volume and Issue: 144(14), P. 1496 - 1507

Published: June 28, 2024

Language: Английский

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The Role of Inflammatory Mediators in the Pathogenesis of Obesity

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2822 - 2822

Published: Aug. 23, 2024

Obesity is a pandemic of the 21st century, and prevalence this metabolic condition has enormously increased over past few decades. associated with number comorbidities complications, such as diabetes cardiovascular disorders, which can be severe fatal outcomes. Adipose tissue an endocrine organ that secretes numerous molecules proteins are capable modifying immune responses. The progression obesity adipose dysfunction, characterised by enhanced inflammation apoptosis. Increased fat-tissue mass dysregulated secretion substances adipocytes, leads to alterations. Importantly, contains cells, profile changes obesity. For instance, increasing fat enhances presence pro-inflammatory variants macrophages, major sources tumour necrosis factor α other inflammatory mediators promote insulin resistance. pathogenesis complex, understanding pathophysiological mechanisms involved may provide novel treatment methods could prevent development serious complications. aim review discuss current evidence describing involvement various in

Language: Английский

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Immune Response in Traumatic Brain Injury

Current Neurology and Neuroscience Reports, Journal Year: 2024, Volume and Issue: 24(12), P. 593 - 609

Published: Oct. 29, 2024

Abstract Purpose of Review This review aims to comprehensively examine the immune response following traumatic brain injury (TBI) and how its disruption can impact healing recovery. Recent Findings The is now considered a key element in pathophysiology TBI, with consequences far beyond acute phase after injury. A delicate equilibrium crucial for healthy When this disrupted, chronic inflammation imbalance lead detrimental effects on survival disability. Summary Globally, imposes substantial burden terms both years life lost lived Although epidemiology exhibits dynamic trends over time across regions, TBI disproportionally affects younger populations, posing psychosocial financial challenge communities families. Following initial trauma, primary succeeded by an inflammatory response, primarily orchestrated innate system. inflammasome plays pivotal role during stage, catalyzing programmed cell death pathways up-regulation cytokines transcription factors. These events trigger activation differentiation microglia, thereby intensifying systemic level facilitating migration cells edema. initially originated brain, monitored our autonomic nervous Through vagus nerve adrenergic cholinergic receptors various peripheral lymphoid organs cells, bidirectional communication regulation between systems established.

Language: Английский

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