Association between pre-ICU aspirin administration and ARDS mortality in the MIMIC-IV database: A cohort study

Pulmonary Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 85, P. 102288 - 102288

Published: March 8, 2024

Language: Английский

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Improving the Wound Healing Process: Pivotal role of Mesenchymal stromal/stem Cells and Immune Cells

Stem Cell Reviews and Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

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Wogonin attenuates inflammation and oxidative stress in acute lung injury via regulating PPARα, AKT, and NRF2

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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Advances in Stem Cell Therapy for Acute Lung Injury: A Review

Journal of Clinical Personalized Medicine, Journal Year: 2025, Volume and Issue: 04(01), P. 326 - 333

Published: Jan. 1, 2025

Language: Английский

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Mouse mesenchymal stem cell-derived exosomal miR-205-5p modulates LPS-induced macrophage polarization and alleviates lung injury by regulating the USP7/FOXM1 axis

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

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The Regenerative Marriage Between High-Density Platelet-Rich Plasma and Adipose Tissue

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2154 - 2154

Published: Feb. 27, 2025

The use of autologous biological preparations (ABPs) and their combinations fills the void in healthcare treatment options that exists between surgical procedures, like plastic reconstructive, cosmetic, orthopedic surgeries; non-surgical musculoskeletal procedures; current pharmaceutical treatments. ABPs, including high-density platelet-rich plasma (HD-PRP), bone marrow aspirate concentrates (BMACs), adipose tissue preparations, with unique stromal vascular fractions (SVFs), can play important roles regeneration repair processes. They be easily safely prepared at point care. Healthcare professionals employ ABPs to mimic classical wound healing cascade, initiate angiogenesis induce regenerative pathways, aiming restore integrity function damaged tissues. In this review, we will address combining HD-PRP tissue, particular fraction (t-SVF), as believe biocellular combination demonstrates a synergistic effect, where constituents enhance potential t-SVF its adipose-derived mesenchymal stem cells (AD-MSCs) pericytes, leading improved functional repair, regeneration, variety clinical applications. We some relevant platelet bio-physiological aspects, since these properties contribute effects t-SVF, promoting overall better outcomes chronic inflammatory conditions, soft rejuvenation.

Language: Английский

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Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by facilitating M2 polarization via CCL2/CCR2 axis and further inducing formation of regulatory CCR2 + CD4 + T cells

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 1, 2025

Our previous study revealed that mesenchymal stem cells (MSCs) can secrete large amounts of the chemokine CCL2 under inflammatory conditions and alleviate idiopathic pneumonia syndrome (IPS) by promoting regulatory CCR2 + CD4 T-cell formation through CCL2‒CCR2 axis. Given abundance macrophages in lung tissue, how these are regulated MSC-based prophylaxis via IPS their interactions with T tissue during allo-HSCT still not fully understood. An mouse model was established, administered. In vitro coculture systems an were used to among MSCs, cells. Prophylactic administration MSCs induced M2 polarization alleviated acute graft-versus-host disease (aGVHD) injury model. studies MSC-released promoted Blocking CCL2-CCR2 interaction reversed MSC-induced abolished induction formation. Additionally, vivo a or antagonist exacerbated aGVHD injury, accompanied reduction reduced tissue. facilitating axis further inducing

Language: Английский

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Cirsium japonicum leaf extract attenuated lipopolysaccharide-induced acute respiratory distress syndrome in mice via suppression of the NLRP3 and HIF1α pathways

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156601 - 156601

Published: March 2, 2025

Language: Английский

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Topological cues of microparticles train stem cells for tissue repair via mechanotransduction

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 531 - 549

Published: March 3, 2025

Language: Английский

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VASP Knockdown Ameliorates Lipopolysaccharide-Induced Acute Lung Injury with Inhibition of M1 Macrophage Polarization Through the cGMP-PKG Signaling Pathway

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Alveolar macrophage (AM) polarization plays a pivotal role in the inflammatory response during acute lung injury (ALI). As reported previously, vasodilator-stimulated phosphoprotein (VASP) may function as an anti-inflammatory agent hepatic tissues. However, specific of VASP ALI-induced remains unclear. To elucidate ALI, we established lipopolysaccharide (LPS)-induced M1 model MH-S cells. RNA sequencing was performed to identify differentially expressed genes polarization. The results revealed significant upregulation gene. Subsequently, gene knockdown lungs achieved by intratracheal delivery VASP-AAV6, and resulting ALI symptoms were assessed. also knocked down cells; these cells then stimulated with LPS for 24 h, polarization-related markers macrophages analyzed. Finally, validate involvement PKG-VASP signaling pathway, experiments conducted PKG agonist (8-Br-cGMP) inhibitor (KT5823), effects modulating pathway on investigated. notably ameliorated mice LPS-induced ALI. Additionally, vitro showed that protected from inhibiting polarization, its protective partially mediated cGMP-PKG pathway.

Language: Английский

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