Postbiotics: emerging therapeutic approach in diabetic retinopathy

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 4, 2024

Diabetic retinopathy (DR) is a prevalent microvascular complication in diabetic patients that poses serious risk as it can cause substantial visual impairment and even vision loss. Due to the prolonged onset of DR, lengthy treatment duration, limited therapeutic effectiveness, extremely important find new strategy for DR. Postbiotic an emerging dietary supplement which consists inactivate microbiota its metabolites. Numerous animal experiments have demonstrated intervention with postbiotics reduces hyperglycemia, attenuates retinal peripapillary endothelial cell damage, improves microcirculatory dysfunction, consequently delays progression More strikingly, unlike conventional probiotics prebiotics, small molecules directly colonize intestinal epithelial cells, exert heat-resistant, acid-resistant, durable storage. Despite few clinical significance, oral administration might become effective management prevention In this review, we summarized basic conception, classification, molecular mechanisms, advances implications pathogenesis Postbiotics present great potential viable adjunctive therapy

Language: Английский

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Association between gut microbiota and diabetic nephropathy: a mendelian randomization study

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: March 27, 2024

Background The correlation between diabetic nephropathy (DN) and gut microbiota (GM) has been suggested in numerous animal experiments cross-sectional studies. However, a causal association GM DN not ascertained. Methods This research adopted MR analysis to evaluate the link derived from data acquired through publicly available genome-wide studies (GWAS). study utilized inverse variance weighted (IVW) approach assess DN. Four additional methods including MR-Egger, median, mode, simple mode were employed ensure comprehensive robust results. Cochran’s Q test MR-Egger method conducted identify heterogeneity horizontal pleiotropy, respectively. leave-one-out was stability of Finally, reverse performed Results According IVW analysis, Class Verrucomicrobiae ( p = 0.003), Order Verrucomicrobiales Family Verrucomicrobiaceae Genus Akkermansia Catenibacterium 0.031), Coprococcus 1 0.022), Eubacterium hallii group 0.018), Marvinbryantia 0.023) associated with higher risk On contrary, Actinobacteria 0.037), Group ventriosum 0.030), Ruminococcus gauvreauii 0.048), Lactobacillales 0.045), Phylum Proteobacteria 0.017) lower sensitivity did any substantial pleiotropy or outcomes. We found effects on 11 species analysis. Notably, are mutually causalities. Conclusion identified which may enhance understanding intestinal-renal axis provide novel potential targets for early non-invasive diagnosis treatment

Language: Английский

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Association of Gut Microbiota with Age-Related Macular Degeneration and Glaucoma: A Bidirectional Mendelian Randomization Study

Nutrients, Journal Year: 2023, Volume and Issue: 15(21), P. 4646 - 4646

Published: Nov. 2, 2023

The objective of this study was to examine the correlation between gut microbiota and both age-related macular degeneration (AMD) glaucoma. Mendelian randomization studies were conducted utilizing data sourced from genome-wide association (GWAS) database for microbiome, AMD, Single nucleotide polymorphism (SNP) estimates summarized through five (MR) methods. We utilized Cochran’s Q statistic evaluate heterogeneity instrumental variables (IVs). Additionally, we employed a “leave-one-out” approach verify stability our findings. Inverse variance weighted (IVW) suggests that Eubacterium (oxidoreducens group) Parabacteroides had protective effect on AMD. Both median IVW suggest Lachnospiraceae (NK4A136 Ruminococcaceae (UCG009) However, Dorea risk Similarly, (ventriosum showed (nodatum group), (NC2004 Roseburia suggested (UCG004) Reverse MR analysis found causal link No relationships AMD or glaucoma other mentioned bacterial groups. significant evidence horizontal pleiotropy detected. This certain bacteria effects while others may be factors Likewise, reverse led an increased abundance bacteria. Further trials are needed clarify specific mechanisms involved.

Language: Английский

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Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(1), P. 5 - 5

Published: Jan. 9, 2025

Purpose: Previous researches have suggested an important association between gut microbiota (GM) and vascular pathologies such as atherosclerosis. This study aimed to explore the 196 GM taxa retinal vein occlusion (RVO). Methods: used Mendelian randomization (MR), linkage disequilibrium score regression (LDSC), polygenic overlap analysis. Genome-wide (GWAS) data associated with was obtained from MiBioGen consortium, involving a large number of European-ancestry participants. GWAS RVO FinnGen consortium another that also involved Inverse-variance weighted primary approach for MR estimation. Moreover, LDSC analyses were performed evaluate genetic correlation RVO. Results: The results identified six taxa, including class Bacilli, order Lactobacillales, family Streptococcaceae, genus Clostridium innocuum group, Family XIII AD3011 Subdoligranulum development In addition, analysis supported Conclusions: Our findings confirmed RVO, thereby highlighting effects on health. Translational Relevance: may provide rationale developing GM-based strategies preventing onset

Language: Английский

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Causal effects of metabolites on malignant neoplasm of bone and articular cartilage: a mendelian randomization study

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: March 3, 2025

Objective Previous research has demonstrated that metabolites play a significant role in modulating disease phenotypes; nevertheless, the causal association between and malignant malignancies of bones joint cartilage (MNBAC)has not been fully elucidated. Methods This study used two-sample Mendelian randomization (MR) to explore correlation 1,400 MNBAC. Data from recent genome-wide studies (GWAS) involving 8,299 individuals were summarized. The GWAS summary data for acquired IEU Open database, while those MNBAC contributed by Finnish Consortium. We employed eight distinct MR methodologies: simple mode, maximum likelihood estimator, robust adjusted profile score, MR-Egger, weighted median, MR-PRESSO inverse variance scrutinize engendered each gene Consequently, we evaluated outliers, horizontal pleiotropy, heterogeneity, impact single nucleotide polymorphisms (SNPs), adherence normal distribution assumption analysis. Results Our findings suggested plausible causative relationship N-Formylmethionine (FMet) levels, lignoceroylcarnitine (C24) observed nearly FMet levels within cohort ( P = 0.024, odds ratio (OR) 3.22; 95% CI [1.16–8.92]). Moreover, ascertained link C24 0.0009; OR 0.420; 95%CI [0.25–0.70]). These results indicate potential FMet, level Conclusion occurrence may be causally related metabolites. might unveil new possibilities investigating early detection treatment

Language: Английский

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