Endometriosis: Part I. Basic concept

Taiwanese Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 61(6), P. 927 - 934

Published: Nov. 1, 2022

Language: Английский

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Molecular Mechanisms for the Vicious Cycle between Insulin Resistance and the Inflammatory Response in Obesity

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 9818 - 9818

Published: June 6, 2023

The comprehensive anabolic effects of insulin throughout the body, in addition to control glycemia, include ensuring lipid homeostasis and anti-inflammatory modulation, especially adipose tissue (AT). prevalence obesity, defined as a body mass index (BMI) ≥ 30 kg/m2, has been increasing worldwide on pandemic scale with accompanying syndemic health problems, including glucose intolerance, resistance (IR), diabetes. Impaired sensitivity or IR paradoxically leads diseases an inflammatory component despite hyperinsulinemia. Therefore, excess visceral AT obesity initiates chronic low-grade conditions that interfere signaling via receptors (INSRs). Moreover, response IR, hyperglycemia itself stimulates primarily defensive associated subsequent release numerous cytokines real threat organ function deterioration. In this review, all components vicious cycle are characterized particular emphasis interplay between both innate adaptive immune responses related obesity. Increased accumulation should be considered main environmental factor responsible for disruption epigenetic regulatory mechanisms system, resulting autoimmunity inflammation.

Language: Английский

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The role of CD8+ T cells in endometriosis: a systematic review

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 11, 2023

Endometriosis is a chronic disease affecting 6-10% of women reproductive age. It an important cause infertility and pelvic pain with poorly understood aetiology. CD8+ T (CD8 T) cells were shown to be linked play significant role in lesion clearance other pathologies, yet their function endometriosis unknown. We systematically evaluated the literature on CD8 peripheral blood endometriosis-associated tissues determine current understanding pathophysiological clinical relevance associated conditions (e.g. pain).

Language: Английский

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The Impact of Endometriosis on Pregnancy

Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 126 - 126

Published: Jan. 22, 2024

Despite the increased frequency of endometriosis, it remains one most enigmatic disorders regarding its effects on pregnancy. Endometriosis adversely affects both natural and assisted conception. Impaired folliculogenesis, which causes follicular dysfunction low egg quality, as well luteal phase problems, reduced fertilization, abnormal embryogenesis, are some mechanisms advocated to explain reproductive dysfunction. There is a rising need for comprehensive study potential negative consequences this condition pregnancy outcomes, including postpartum period, more women with medical history endometriosis become pregnant. Obstetrical complications (small gestational age [SGA], cesarean section [CS], miscarriage, hemorrhage, placental adhesion, preterm delivery) statistically elevated in endometriosis. Furthermore, ruptured ovarian endometrioma, appendicitis, intestinal perforation, hemoperitoneum have been described Obstetricians largely unfamiliar these complications, they not thoroughly investigated. The development pathogenesis an important field has yet fully elucidated. Finding crucial new effective strategies treat condition. can impact obstetric neonatal outcomes pregnancy, addition To date, no additional monitoring recommended pregnancies However, studies urgently needed assess tailored

Language: Английский

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Omics-based novel strategies in the diagnosis of endometriosis

Critical Reviews in Clinical Laboratory Sciences, Journal Year: 2023, Volume and Issue: 61(3), P. 205 - 225

Published: Oct. 25, 2023

Endometriosis, an enigmatic and chronic disorder, is considered a debilitating condition despite being benign. Globally, this gynecologic disorder affects up to 10% of females reproductive age, impacting almost 190 million individuals. A variety genetic environmental factors are involved in endometriosis development, hence the pathophysiology etiology remain unclear. The uncertainty disease its complexity along with nonspecific symptoms have led misdiagnosis or lack diagnosis affected people. Biopsy laparoscopy referred as gold standard for diagnosis. However, invasiveness procedure, unnecessary operation disease-free women, dependence reliability on experience area most significant limitations. Therefore, continuous studies attempted offer noninvasive reliable approach. recent advances modern technologies generation large-scale biological data sets, known –omics data, resulting proceeding century biomedical sciences. Thereby, present study critically reviews novel biomarkers that based approaches from 2020 onward. findings reveal identified genomics, epigenomics, transcriptomics, proteomics, metabolomics potentially able diagnose endometriosis, predict prognosis, stage patients, potentially, near future, multi-panel these will generate clinical benefits.

Language: Английский

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Flavonoids Quercetin and Kaempferol Are NR4A1 Antagonists and Suppress Endometriosis in Female Mice

Endocrinology, Journal Year: 2023, Volume and Issue: 164(10)

Published: Aug. 28, 2023

Nuclear receptor 4A1 (NR4A1) plays an important role in endometriosis progression; levels of NR4A1 endometriotic lesions are higher than normal endometrium, and substituted bis-indole analogs antagonists suppress progression mice with endometriosis. In addition, the flavonoids kaempferol quercetin natural products that directly bind significantly repress intrinsic NR4A1-dependent transcriptional activity human epithelial stromal cells Ishikawa endometrial cancer cells. knockdown inhibition by suppressed proliferation inhibiting epidermal growth factor receptor/c-Myc/survivin-mediated growth-promoting survival pathways, The mammalian target rapamycin (mTOR) signaling αSMA/CTGF/COL1A1/FN-mediated fibrosis but increasing Thioredoxin domain Containing 5/SESN2-mediated oxidative/estrogen receptors stress signaling. cells, primarily inhibited mTOR suppressing treatment also effectively compared vehicle without any body weight changes. Therefore, potential as nutritional therapy for

Language: Английский

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Bioinformatic Analysis of m6A Regulator-Mediated RNA Methylation Modification Patterns and Immune Microenvironment Characterization in Endometriosis

Biochemical Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: March 7, 2024

Language: Английский

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Unraveling the microbial puzzle: exploring the intricate role of gut microbiota in endometriosis pathogenesis

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Feb. 16, 2024

Endometriosis (EMs) is a prevalent gynecological disorder characterized by the growth of uterine tissue outside cavity, causing debilitating symptoms and infertility. Despite its prevalence, exact mechanisms behind EMs development remain incompletely understood. This article presents comprehensive overview relationship between gut microbiota imbalance pathogenesis. Recent research indicates that plays pivotal role in various aspects EMs, including immune regulation, generation inflammatory factors, angiopoietin release, hormonal endotoxin production. Dysbiosis can disrupt responses, leading to inflammation impaired clearance endometrial fragments, resulting endometriotic lesions. The dysregulated contribute release lipopolysaccharide (LPS), triggering chronic promoting ectopic adhesion, invasion, angiogenesis. Furthermore, involvement estrogen metabolism affects levels, which are directly related development. review also highlights potential as diagnostic tool therapeutic target for EMs. Interventions such fecal transplantation (FMT) use preparations have demonstrated promising effects reducing symptoms. progress made, further needed unravel intricate interactions paving way more effective prevention treatment strategies this challenging condition.

Language: Английский

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Perturbations of the endometrial immune microenvironment in endometriosis and adenomyosis: their impact on reproduction and pregnancy

Seminars in Immunopathology, Journal Year: 2025, Volume and Issue: 47(1)

Published: Feb. 18, 2025

Abstract The impact of endometriosis and adenomyosis on reproduction pregnancy is significant, with both conditions linked to increased rates infertility, poor ovarian function in women endometriosis, elevated complications those adenomyosis. However, the underlying mechanisms remain largely unclear. Both share a similar pathophysiological process characterized by growth ectopic endometrium, which may originate from eutopic endometrium. Notably, surgical removal lesions does not appear significantly improve reproductive outcomes, further underscoring importance endometrium these adverse effects. Emerging evidence indicates substantial differences endometrial NK cells, macrophages, T leading inflammatory responses These alterations contribute only disease progression but also defective receptivity, insufficient angiogenesis remodeling, impaired maternal-fetal immune tolerance, placentation, thereby influencing embryo implantation maintenance. This provides an immunological perspective explain higher infertility observed affected women. Therefore, we systematically review cells compared healthy controls, exploring potential impacts changes pregnancy. aims lay groundwork for future studies immunopathogenesis associated adenomyosis-related failure complications, shedding lights development immunotherapeutic strategies mitigate

Language: Английский

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Insight into the Potential Mechanisms of Endocrine Disruption by Dietary Phytoestrogens in the Context of the Etiopathogenesis of Endometriosis

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12195 - 12195

Published: July 30, 2023

Phytoestrogens (PEs) are estrogen-like nonsteroidal compounds derived from plants (e.g., nuts, seeds, fruits, and vegetables) fungi that structurally similar to 17β-estradiol. PEs bind all types of estrogen receptors, including ERα ERβ nuclear a membrane-bound receptor known as the G protein-coupled (GPER). As endocrine-disrupting chemicals (EDCs) with pro- or antiestrogenic properties, can potentially disrupt hormonal regulation homeostasis, resulting in developmental reproductive abnormalities. However, lack diet does not result development deficiency symptoms. To properly assess benefits risks associated use PE-rich diet, it is necessary distinguish between endocrine disruption (endocrine-mediated adverse effects) nonspecific effects on system. Endometriosis an estrogen-dependent disease unknown etiopathogenesis, which tissue lining uterus (the endometrium) grows outside subsequent complications being manifested local inflammatory reactions. affects 10–15% women age chronic pelvic pain, dysmenorrhea, dyspareunia, infertility. In this review, endocrine-disruptive actions reviewed context endometriosis determine whether has positive negative effect risk course endometriosis.

Language: Английский

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