Examination of cord blood at birth in women with SARS-CoV-2 exposure and/or vaccination during pregnancy and relationship to fetal complete blood count, cortisol, ferritin, vitamin D, and CRP DOI Creative Commons
Eric M. Mendenhall,

Mary Beth Hogan,

Matthew Nudelman

et al.

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 11

Published: March 16, 2023

SARS-CoV-2 is known to manifest a robust innate immune response. However, little about inflammatory influences from maternal infection or mRNA vaccination upon the fetus. In addition, it unknown if Vitamin D deficiency fetal homeostasis an anti-inflammatory mechanism development of possible cytokines acute phase reactants by maternal/fetal dyad, in form cortisol elevations, occur. effects on Complete Blood Count (CBC) are not known.To evaluate neonatal and responses after disease vaccination.Samples medical records reviews mother/baby dyads (n = 97) were collected consecutively, categorized into 4 groups; no exposure (Control), Vaccinated mothers, positive/IgG titer positive blood, negative blood. IgG/IgM/IgA titers, CBC, CRP, ferritin, cortisol, obtained examine response Student's t-test, Wilcoxon rank-sum, Chi-squared with Bonferroni corrections used compare groups. Multiple imputations performed for missing data.Cortisol was higher babies both mothers who vaccinated (p 0.001) 0.009) as compared control group suggesting attempt maintain these Measurements vitamin did reach statistical significance. CBC showed variation, except mean platelet volume (MPV), which elevated whose 0.003) 0.007) group.Acute reactant elevations noted our neonates. levels unchanged homeostatic levels. Cord blood at birth, Cortisol MPV IgG Control group, indicating that generated. The implication events subsequent and/or elevation fetus merits further investigation.

Language: Английский

Examination of cord blood at birth in women with SARS-CoV-2 exposure and/or vaccination during pregnancy and relationship to fetal complete blood count, cortisol, ferritin, vitamin D, and CRP DOI Creative Commons
Eric M. Mendenhall,

Mary Beth Hogan,

Matthew Nudelman

et al.

Frontiers in Pediatrics, Journal Year: 2023, Volume and Issue: 11

Published: March 16, 2023

SARS-CoV-2 is known to manifest a robust innate immune response. However, little about inflammatory influences from maternal infection or mRNA vaccination upon the fetus. In addition, it unknown if Vitamin D deficiency fetal homeostasis an anti-inflammatory mechanism development of possible cytokines acute phase reactants by maternal/fetal dyad, in form cortisol elevations, occur. effects on Complete Blood Count (CBC) are not known.To evaluate neonatal and responses after disease vaccination.Samples medical records reviews mother/baby dyads (n = 97) were collected consecutively, categorized into 4 groups; no exposure (Control), Vaccinated mothers, positive/IgG titer positive blood, negative blood. IgG/IgM/IgA titers, CBC, CRP, ferritin, cortisol, obtained examine response Student's t-test, Wilcoxon rank-sum, Chi-squared with Bonferroni corrections used compare groups. Multiple imputations performed for missing data.Cortisol was higher babies both mothers who vaccinated (p 0.001) 0.009) as compared control group suggesting attempt maintain these Measurements vitamin did reach statistical significance. CBC showed variation, except mean platelet volume (MPV), which elevated whose 0.003) 0.007) group.Acute reactant elevations noted our neonates. levels unchanged homeostatic levels. Cord blood at birth, Cortisol MPV IgG Control group, indicating that generated. The implication events subsequent and/or elevation fetus merits further investigation.

Language: Английский

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