Multi‐Omic Insight Into the Molecular Networks in the Pathogenesis of Coronary Artery Disease

Journal of the American Heart Association, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Background Genome‐wide association studies have revealed numerous loci associated with coronary artery disease (CAD). However, some potential causal/risk genes remain unidentified, and causal therapies are lacking. Methods Results We integrated multi‐omics data from gene methylation, expression, protein levels using summary data‐based Mendelian randomization colocalization analysis. Candidate were prioritized based on protein‐level associations, probability, links to methylation expression. Single‐cell RNA sequencing used assess differential expression in the arteries of patients CAD. TAGLN2 ( Transgelin 2 ), APOB Apolipoprotein B GIP Glucose‐dependent insulinotropic polypeptide ) identified as most strongly CAD, exhibiting significant association. Higher at specific Cytosine‐phosphate‐Guanine sites negatively correlated its a lower risk whereas higher circulating positively CAD (odds ratio,1.66 [95% CI, 1.32–2.08). These results suggest distinct regulatory mechanisms for . In contrast, showed positive associations risk, DHX58 DExH‐box helicase 58 SWAP70 Switch‐associated 70 decreased risk. Conclusions Our findings provide evidence suggesting that , This work provides novel insights into molecular highlights integrating uncover relationships cannot be fully captured by traditional genome‐wide studies.

Language: Английский

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Bibliometric analysis of multimodal analgesia research in the perioperative period: trends, contributions, and emerging areas (2013–2023)

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 3, 2025

Multimodal analgesia (MA) is a cornerstone in perioperative pain management, enhancing relief and minimizing opioid consumption by targeting various pathways. This study conducts bibliometric analysis of MA research from 2013 to 2023 understand its development impact on care. A comprehensive literature search the Web Science Core Collection (WOSCC) was conducted, covering publications January December 2023. Data were analyzed using VOSviewer other tools identify publication trends, key contributors, emerging themes. The identified 1,939 studies MA, with notable increase annual since 2020. USA, China, Canada leading contributors. Key terms like Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Enhanced Recovery After Surgery (ERAS), Patient-Controlled Analgesia (PCA) frequently associated MA. Significant journals included Cureus Journal Medical Anesthesia Analgesia. Influential authors such as Richard D. Urman Henrik Kehlet highlighted for their contributions. showed significant advancements growing global interest underscores importance contributions countries researchers. Future should focus optimizing management protocols, patient recovery, reducing dependency through

Language: Английский

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A bibliometric and visual analysis of the impact of senescence on tumor immunotherapy

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 11, 2025

Background Recently, many studies have focused on the relationship between senescence and immunotherapy in cancer treatment. However, relatively few examined intrinsic links three. Whether these can act synergistically fight against specific them are still unclear. Methods We extracted, quantified, visualized data from literature (n = 2396) for period 2004-2023 after rigorous quality control using citespace, GraphPad Prism, R software package, VOSviewer. Results Linear fit analyses were generated to predict number of annual publications citations as a function top-performing authors, journals, countries, affiliations academically over past two decades such Weiwei, Aging-us, China, UT MD Anderson Cancer Center. Vosviewer-based hierarchical clustering further categorized study characteristics into six clusters, including major clusters research, immunosenescence-related research factors, timeline distributions suggesting that cellular tumor progression is new cluster warrants exploration development. Study characterization bursts linear regression confirmed findings revealed other important results, aging (a 1.964, R² 0.6803) 16.38, 0.8812). Furthermore, gene frequency analysis this most abundant gene, APOE , SIRT1-7 proteins. Conclusion The combination therapies with immunotherapies currently its preliminary stages. Although has greatest impact ICB therapies, mechanistic investigations, drug development sirt1-7 (Sirtuins family) targets may be key combining treatment tumors.

Language: Английский

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The top 100 most cited articles in the treatment of basal cell carcinoma over the last decade: A bibliometric analysis and review

Medicine, Journal Year: 2024, Volume and Issue: 103(15), P. e37629 - e37629

Published: April 12, 2024

Basal cell carcinoma (BCC) represents the most prevalent cancer globally. The past decade has witnessed significant advancements in BCC treatment, primarily through bibliometric studies. Aiming to perform a comprehensive analysis of treatments comprehend research landscape and identify trends within this domain, dataset comprising 100 scientific publications from Web Science Core Collection was analyzed. Country co-operation, journal co-citation, theme bursts, keyword co-occurrence, author literature field-specific references were examined using VOSviewer CiteSpace visualization tools. These articles, published between 2013 2020, originated predominantly 30 countries/regions 159 institutions, with USA Germany at forefront, involving total 1118 authors. revealed emphasis on hedgehog pathway, Mohs micrographic surgery, photodynamic therapy. shows developed nations are forefront advancing therapies, focus drugs targeting pathway. This treatment avenue emerged as crucial area, meriting considerable attention therapeutic strategies.

Language: Английский

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Global trends in Cryptococcus and its interactions with the host immune system: a bibliometric analysis

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 7, 2024

Objectives This manuscript undertakes a systematic examination of the research landscape concerning global Cryptococcus species and their dynamism with host immune system spanning past decade. It furnishes detailed survey leading knowledge institutions critical focal points in this area, utilizing bibliometric analysis. Methods VOSviewer CiteSpace software platforms were employed to systematically analyze graphically depict relevant literature indexed WoSCC database over preceding ten years. Results In interval between October 1, 2013, 2023, corpus 795 publications was amassed. The primary involved study include Duke University, University Minnesota, Sydney. trio nations, terms publication volume, comprises United States, China, Brazil. Among most prolific authors are Casadevall, Arturo; Wormley, Floyd L., Jr.; Olszewski, Michal A., highly cited author being Perfect, Jr. esteemed journal is Mbio, while Infection Immunity commands highest citation frequency, Journal Clinical Microbiology boasts significant impact factor. Present foci encompass intricate interactions pathogenesis immunity, alongside mechanisms, complications, immunotherapies. Conclusion represents first exhaustive scholarly review scrutiny evolving landscapes its system. analyses delineated herein provide insights into prevailing trajectories, thus furnishing directions for subsequent inquiries domain.

Language: Английский

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