Evaluating the efficacy and safety of neoadjuvant immunochemotherapy versus chemotherapy in locally advanced gastric cancer undergoing radical gastrectomy: a retrospective study

World Journal of Surgical Oncology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

Locally advanced gastric cancer (LAGC) is challenging to treat, with neoadjuvant chemotherapy (NCT) improving survival. Recent advances suggest that immunochemotherapy (NICT) may enhance treatment outcomes. This study compares the efficacy and safety of NICT NCT in LAGC patients who received radical surgery. We retrospectively analyzed 67 treated at China-Japan Friendship Hospital from January 2023 2024. Patients were divided into two groups: (chemotherapy plus PD-1/PD-L1 inhibitors) (standard chemotherapy). compared pathological complete response (pCR), postoperative recovery, complications, laboratory markers. The group demonstrated a significantly higher pCR rate (25.7% vs. 6.2%, P = 0.032) group. Furthermore, showed reduced rates nerve vascular invasion (28.6% 31.4%, 0.041). Tumor regression grades (P 0.001) more favorable group, earlier ypN ypTNM stages 0.001). Laboratory analysis revealed greater reduction tumor markers CEA CA19-9 groups, decreased white blood cell counts elevated liver enzymes. Surgical outcomes, including operative time, loss, hospital stay, similar between no significant increase complications effective than traditional responses reducing burden patients. It also without increasing surgical risks.

Language: Английский

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Prognostic value of neutrophil to lymphocyte ratio in gastric cancer patients receiving immune checkpoint inhibitors: a systematic review and meta-analysis

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: April 18, 2023

The neutrophil to lymphocyte ratio (NLR) is a cost-effective and easily identifiable inflammatory biomarker that has been shown be closely associated with tumor prognosis predict survival in patients multiple malignancies. However, the predictive value of NLR gastric cancer (GC) treated immune checkpoint inhibitors (ICIs) not fully explored. Therefore, we conducted meta-analysis explore potential as predictor this population.We systematically searched PubMed, Cochrane Library, EMBASE databases from inception present for observational researches on its relationship progression or GC receiving ICIs. To assess prognostic significance overall (OS) progression-free (PFS), used fixed random-effect models derive combine hazard ratios (HRs) 95% confidence intervals (CIs). We also examined between treatment efficacy by calculating relative risks (RRs) CIs objective response rate (ORR) disease control (DCR) ICIs.Nine studies 806 were eligible. OS PFS data obtained 9 5 studies, respectively. In nine was poor survival, pooled HR 1.98 (95% CI 1.67- 2.35, p < 0.001), indicating significant association high worse OS. subgroup analyses based study characteristics confirm robustness our findings. A reported five 1.49 0.99- 2.23, = 0.056), which significantly associated. Pooling four correlation ORR/DCR patients, observed ORR (RR 0.51, 0.003), but no DCR 0.48, 0.111).In summary, indicates increased linked addition, lowering can improve ORR. Thus, serve Nevertheless, further high-quality prospective are required verify findings future.

Language: Английский

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Mechanism of Yinxu Weitong Capsule in the treatment of precancerous lesions of gastric cancer based on network pharmacology and experimental validation

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 341, P. 119303 - 119303

Published: Jan. 5, 2025

Language: Английский

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Mapping the landscape of gastric cancer immunotherapy: Bibliometric insights into advances and hotspots

World Journal of Gastrointestinal Oncology, Journal Year: 2025, Volume and Issue: 17(3)

Published: Feb. 13, 2025

BACKGROUND Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer (GC). A comprehensive review of advancements, current status, and research trends in GC immunotherapy is essential to inform future investigative efforts. AIM To delineate the trends, focal points GC. METHODS We performed bibliometric analysis 2906 articles English concerning published from 2000 December 20, 2023, indexed Web Science Core Collection. Data visualization were facilitated by CiteSpace (6.1.6R), VOSviewer v.1.6.17, GraphPad Prism v8.0.2. RESULTS There been an increase annual publication rate research. China leads volume, while United States demonstrates highest citation impact. Fudan University notable its frequency output. Co-citation keyword revealed highlighted focus on prognosis, tumor microenvironment (TME), integrative with targeted therapy. Emerging areas include gastroesophageal junction cancer, adoptive immunotherapy, role Treg cell immunotherapy. CONCLUSION expanding field attracting considerable scientific interest. With clinical adoption GC, primary goals are enhance treatment efficacy patient outcomes. Unlike hematological malignancies, GC's solid TME presents distinct immunological challenges that may attenuate cytotoxic effects immune cells cells. For instance, although CAR-T therapy effective it underperformed settings. Current centered overcoming immunosuppression within TME, combinations therapy, dynamics, precise prognosis prediction Additionally, immunotherapy's treating become novel focus.

Language: Английский

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Cutting-Edge Technological Developments in the Diagnosis and Treatment of Malignant Gastric Neoplasm

Advances in Science, Technology & Innovation/Advances in science, technology & innovation, Journal Year: 2025, Volume and Issue: unknown, P. 211 - 242

Published: Jan. 1, 2025

Language: Английский

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