TLR3 signaling-induced interferon-stimulated gene 56 plays a role in the pathogenesis of rheumatoid arthritis DOI Creative Commons

Hikaru Kristi Ishibashi,

Yuzuru Nakamura, Tatsuro Saruga

et al.

Experimental Biology and Medicine, Journal Year: 2024, Volume and Issue: 249

Published: May 31, 2024

Rheumatoid fibroblast-like synoviocytes (RFLS) have an important role in the inflammatory pathogenesis of rheumatoid arthritis (RA). Toll-like receptor 3 (TLR3) is upregulated RFLS; its activation leads to production interferon-β (IFN-β), a type I IFN. IFN-stimulated gene 56 (ISG56) induced by IFN and involved innate immune responses; however, RA remains unknown. Therefore, purpose this study was investigate TLR3-induced ISG56 human RFLS. RFLS were treated with polyinosinic-polycytidylic acid (poly I:C), which served as TLR3 ligand. ISG56, melanoma differentiation-associated 5 (MDA5), C-X-C motif chemokine ligand 10 (CXCL10) expression measured using quantitative reverse transcription-polymerase chain reaction, western blotting, enzyme-linked immunosorbent assay. Using immunohistochemistry, we found that expressed synovial tissues patients osteoarthritis. Under poly I:C treatment, In addition, IFN-neutralizing antibody mixture suppressed expression. knockdown decreased CXCL10 MDA5 strongly cells RA. signaling also be associated expression, suggesting may TLR3/type IFN/CXCL10 axis, play inflammation.

Language: Английский

The relationship and clinical significance of lactylation modification in digestive system tumors DOI Creative Commons
Gang Wang,

Xiaosu Zou,

Qicong Chen

et al.

Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)

Published: July 15, 2024

Lactylation, an emerging post-translational modification, plays a pivotal role in the initiation and progression of digestive system tumors. This study presents comprehensive review lactylation tumors, underscoring its critical involvement tumor development progression. By focusing on metabolic reprogramming, modulation microenvironment, molecular mechanisms regulating progression, potential targeting as therapeutic strategy is highlighted. The research reveals that participates gene expression regulation cell signaling by affecting states histones non-histone proteins, thereby influencing pathways immune evasion cells. Furthermore, this assesses feasibility target, providing insights for clinical treatment gastrointestinal cancers. Future should concentrate elucidating lactylation, developing efficient inhibitors, validating their efficacy trials, which could transform current cancer immunotherapy approaches. In summary, emphasizes crucial tumorigenesis through detailed analysis significance.

Language: Английский

Citations

7
Pre-clinical study of curcumin in the treatment of gastric Cancer DOI
Minghui Hao, Chungang Zhang

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106677 - 106677

Published: Jan. 18, 2025

Language: Английский

Citations

0
Potential of curcumin and its derivatives, modern insights on the anticancer properties: a comprehensive overview DOI

R. Ullah,

Muhammad Siraj, Javed Iqbal

et al.

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Globally, cancer is the top cause of mortality, placing a heavy load on medical system. One first known secondary metabolites curcumin, bioactive substance. This study aims to emphasize chemopreventive and chemotherapeutic properties curcumin its derivatives, therefore, offering important insights for possible creation certain supplemental medications treatment different cancers. Electronic Google databases, including scholar, ResearchGate, PubMed/Medline, ScienceDirect, were searched gather pertinent data about effects derivatives. Various studies have revealed diverse array significant biological effects. The majority investigations pertaining potential anticancer associated processes are currently in experimental preclinical stage lack sufficient clinical trial validate their findings. Clinical research further needed clarify molecular specific targeted action as well toxicity side humans, order open up new therapeutic avenues treating cancer.

Language: Английский

Citations

0
Editorial: Current insights in cancer metabolism and T cell based tumor immunity DOI Creative Commons
Takashi Maruyama, Takashi Tanikawa, Jian Gu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 18, 2025

Shen et al. identified differences in immune activity, lipid biosynthesis, and drug metabolism between low-and high-risk survival groups of estrogen receptor-positive breast cancer patients (ER+BR) (5). The analysis revealed that express high levels ALOX15, a gene associated with metabolism, which is positively correlated tumor size vascular invasion. authors have suggested modulation could enhance the efficacy anticancer therapies.In conclusion, within microenvironment plays crucial role regulating both growth response. Lipid exerts significant influence on characteristics functionality cells. A comprehensive understanding these metabolic interactions facilitate development innovative therapeutic strategies combine checkpoint inhibitors to anti-tumor immunity.

Language: Английский

Citations

0
Curcumin's Dose-Dependent Attenuation of Gastric Cancer Cell Progression Via the PI3K Pathway Blockade DOI Creative Commons

Gen Xi,

Qingtao Dong,

Bo Yang

et al.

Dose-Response, Journal Year: 2023, Volume and Issue: 21(4)

Published: Oct. 1, 2023

Background: Gastric cancer stands as a primary cause of cancer-related deaths worldwide, making the discovery new therapeutic agents essential for enhancing treatment outcomes. Curcumin, polyphenolic compound found in turmeric (Curcuma longa), has demonstrated potential multiple types due to its anti-cancer characteristics. This research aimed examine impact curcumin on gastric cell growth, migration, and invasion, well influence phosphoinositide 3-kinase (PI3K) signaling cascade. Methods: lines were exposed varying concentrations, followed by assessments viability, invasion. Furthermore, gene protein expression levels associated with PI3K cascade evaluated using reverse transcription-polymerase chain reaction (RT-PCR) Western blot analysis. Results: The findings revealed dose-dependent decrease invasion cells treated curcumin. Additionally, administration led downregulation key genes proteins within process, such PI3K, Akt, mTOR. Conclusion: These propose that may exercise effects cells, partly suppressing pathway. study's outcomes support curcumin's agent encourage further exploration underlying molecular mechanisms vivo effectiveness.

Language: Английский

Citations

7
Promises of natural products as clinical applications for cancer DOI
Rui Deng,

Gangfan Zong,

Xi Wang

et al.

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1880(1), P. 189241 - 189241

Published: Dec. 12, 2024

Language: Английский

Citations

2
Mono-Carbonyl Curcumin Analogs for Cancer Therapy DOI Open Access
Takashi Maruyama, Hiroyuki Yamakoshi, Yoshiharu Iwabuchi

et al.

Biological and Pharmaceutical Bulletin, Journal Year: 2023, Volume and Issue: 46(6), P. 756 - 763

Published: May 31, 2023

Curcumin has long been recognized for its anti-inflammatory properties. An antitumor effect recently reported in curcumin and clinical trials are being conducted. However, a large amount of required intake to obtain the regarded as problem. Therefore, analogs have created by many researchers enhance effects curcumin. We synthesized >50 revealed greater growth suppression various tumor cells with mono-carbonyl than Mechanistically, inhibited transcriptional activity (e.g., nuclear factor kappa B, signal transducer, activator transcription 3) or activated caspase-3. Additionally, control cell metabolism. Herein, we summarize current knowledge about discuss their potential applications.

Language: Английский

Citations

4
Inhibition of thioredoxin-1 enhances the toxicity of glycolysis inhibitor 2-deoxyglucose by downregulating SLC1A5 expression in colorectal cancer cells DOI

Tianbin Tang,

Daoquan Fang, Ziwei Ji

et al.

Cellular Oncology, Journal Year: 2023, Volume and Issue: 47(2), P. 607 - 621

Published: Oct. 23, 2023

Language: Английский

Citations

4
TLR3 signaling-induced interferon-stimulated gene 56 plays a role in the pathogenesis of rheumatoid arthritis DOI Creative Commons

Hikaru Kristi Ishibashi,

Yuzuru Nakamura, Tatsuro Saruga

et al.

Experimental Biology and Medicine, Journal Year: 2024, Volume and Issue: 249

Published: May 31, 2024

Rheumatoid fibroblast-like synoviocytes (RFLS) have an important role in the inflammatory pathogenesis of rheumatoid arthritis (RA). Toll-like receptor 3 (TLR3) is upregulated RFLS; its activation leads to production interferon-β (IFN-β), a type I IFN. IFN-stimulated gene 56 (ISG56) induced by IFN and involved innate immune responses; however, RA remains unknown. Therefore, purpose this study was investigate TLR3-induced ISG56 human RFLS. RFLS were treated with polyinosinic-polycytidylic acid (poly I:C), which served as TLR3 ligand. ISG56, melanoma differentiation-associated 5 (MDA5), C-X-C motif chemokine ligand 10 (CXCL10) expression measured using quantitative reverse transcription-polymerase chain reaction, western blotting, enzyme-linked immunosorbent assay. Using immunohistochemistry, we found that expressed synovial tissues patients osteoarthritis. Under poly I:C treatment, In addition, IFN-neutralizing antibody mixture suppressed expression. knockdown decreased CXCL10 MDA5 strongly cells RA. signaling also be associated expression, suggesting may TLR3/type IFN/CXCL10 axis, play inflammation.

Language: Английский

Citations

1