Post-COVID-19 syndrome: When an acute infection causes a chronic illness

Acta Colombiana de Cuidado Intensivo, Journal Year: 2024, Volume and Issue: 24(4), P. 387 - 397

Published: June 20, 2024

Language: Английский

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Monitoring the Immune System in Critically Ill Patients (Review)

General Reanimatology, Journal Year: 2024, Volume and Issue: 20(3), P. 42 - 52

Published: May 30, 2024

Most patients with critical illness, regardless of the cause, develop activation innate and adaptive immunity. This is often a process leading to organ dysfunction. The aim review systematize information on monitoring immune system in illness for physicians different specialties (anesthesiology intensive care, surgery, general practice, obstetrics gynecology). includes from 83 recent national international publications (mostly 2023), available public domain found by keyword search. We have summarized current understanding relationship between infections human system, as well clinical application traditional markers status. provided data novel promising assessment immunity various diseases. Limitations studies reviewed include need additional large-scale trials even most markers, synthesis evidence their performance. In addition, likely increase cost patient necessitating development more affordable research methods. Conclusion. Almost all disorders critically ill are associated changes system. Management based profile requires determination personalized strategy modulation, treatment, prevention infection. Advanced functions will contribute personalization medicine, continuous biological technologies allow improve its

Language: Английский

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Mendelian randomization provides causal association between COVID-19 and thyroid cancer: insights from a multi-cancer analysis

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 10, 2024

Since the onset of COVID-19 pandemic, SARS-CoV-2 virus has caused over 600 million confirmed infections and more than 6.8 deaths worldwide, with ongoing implications for human health. been extensively documented to have extrapulmonary manifestations due widespread expression necessary ACE2 receptors in body. Nevertheless, association between cancer risk remains inadequately explored. This study employs Mendelian randomization (MR) methods examine causal relationship genetic variations associated developing cancer. The findings indicate that negligible impact on most risks. Interestingly, a higher is decreased thyroid In summary, our demonstrate correlation cancer, contributing understanding interplay risk.

Language: Английский

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Aeroallergen immunotherapy associated with reduced risk of severe COVID-19 in 1095 allergic patients

World Allergy Organization Journal, Journal Year: 2023, Volume and Issue: 16(5), P. 100779 - 100779

Published: May 1, 2023

IntroductionAllergen immunotherapy (AIT) brings along changes in the immune system, restoring dendritic cell function, reducing T2 inflammation and augmenting regulatory activation. Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, interferes with system causing suppression during first phase over-activation more advanced disease. We decided to explore interaction of both a real-world observational trial.MethodsWe registered COVID-19 outcomes patients allergic disorders Latin America, treated without AIT. The registry was conducted 1.3 years pandemic, most data collected before vaccination concluded countries. Data collection anonymous via web-based instrument. Ten countries participated.Results630/1095 (57.6%) included received Compared AIT, those AIT had reduced risk ratio (RR) for lower symptoms (RR 0.78, 95% CI: 0.6703–0.9024; p = 0.001662) need oxygen therapy 0.65, 0.4217–0.9992; 0.048). In adherent on maintenance sublingual immunotherapy/subcutaneous (SLIT/SCIT) RR reduction larger [RR 0.6136 (95% CI 0.4623–0.8143; < 0.001) RR: 0.3495 0.1822–0.6701; 0.005), respectively]. SLIT slightly effective (NS). excluded age, comorbidities, level health care attendance, type disorder as confounders, although asthma related higher frequency When analyzing (n 503) favoring pronounced 30% or worse 0.6914, 0.5264 0.9081, 0.0087) 51% 0.4868, 0.2829–0.8376, 0.0082). Among biologics 24) only 2/24 needed therapy. There were no critical cases among them.ConclusionIn our associated severity.

Language: Английский

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Clinical Characteristics of Myasthenia Gravis Patients with COVID-19 in Guangxi, China: A Case–Control Study

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 3157 - 3168

Published: July 1, 2023

With the adjustment of prevention strategies in December 2022, coronavirus disease 2019 (COVID-19) became widely prevalent China. This study is aimed to describe clinical characteristics myasthenia gravis (MG) patients with COVID-19 and identify risk factors exacerbation MG Guangxi.A total 489 587 control subjects Guangxi during pandemic were enrolled this case-control study. After contacting participants, data group analyzed. The described. Multivariable logistic regression analysis was used for discovering independent COVID-19.A 311 (75.30%) 428 (72.91%) infected COVID-19, 64.31% women. median age at time interview 41 (IQR: 28, 54) years old, onset 36 24, 51), both which lower than those without COVID-19. duration 24 9, 72) months. About 44.69% generalized (GMG). 11.90% showed severe symptoms symptomatic 9.57 ± 6.79 days, higher group. 35.69% immunosuppressive drugs non-infected (21.57%). A 120 (38.59%) had comorbidities. 21 (20.19%) 104 vaccination symptoms. that baseline activities daily living profile (MG-ADL, OR 1.280, 95% CI: 1.010-1.621, p = 0.041), (OR 1.158, 1.100-1.220, < 0.001), GMG 2.331, 1.228, 4.426, 0.010), lack COVID 2.075, 1.152, 3.738, 0.015) COVID-19.MG drugs, younger onset, longer duration, or comorbidities are more susceptible MG-ADL, GMG,

Language: Английский

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