Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117293 - 117293
Published: Aug. 14, 2024
Breast
cancer
is
one
of
the
most
prevalent
malignancies
among
women.
Enhancing
prognosis
an
effective
approach
to
enhance
survival
rate
breast
cancer.
Cuproptosis,
a
copper-dependent
programmed
cell
death
process,
has
been
associated
with
patient
prognosis.
Inducing
cuproptosis
promising
for
therapy.
However,
there
currently
no
anti-breast
drug
that
induces
cuproptosis.
In
this
study,
we
repositioned
clinical
fluphenazine
as
potential
agent
treatment
by
inducing
Firstly,
utilized
Cancer
Genome
Atlas
(TCGA)
database
and
Connectivity
Map
(CMap)
identify
22
compounds
activity
through
Subsequently,
our
findings
demonstrated
effectively
suppressed
viability
MCF-7
cells.
Fluphenazine
also
significantly
inhibited
triple
negative
cells
MDA-MB-453
MDA-MB-231.
Furthermore,
study
revealed
down-regulated
expression
prognostic
biomarkers
cuproptosis,
increased
copper
ion
levels,
reduced
intracellular
pyruvate
accumulation.
Additionally,
it
up-regulated
FDX1
at
both
mRNA
protein
which
reported
play
crucial
role
in
induction
These
suggest
be
used
Therefore,
research
provides
insight
development
novel
cuproptosis-dependent
anti-cancer
agents.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: March 28, 2024
Glioblastoma,
a
notably
aggressive
brain
tumor,
is
characterized
by
brief
survival
period
and
resistance
to
conventional
therapeutic
approaches.
With
the
recent
identification
of
“Cuproptosis,”
copper-dependent
apoptosis
mechanism,
this
study
aimed
explore
its
role
in
glioblastoma
prognosis
potential
implications.
A
comprehensive
methodology
was
employed,
starting
with
analysis
65
cuproptosis-related
genes.
These
genes
were
subjected
differential
expression
analyses
between
tissues
normal
counterparts.
novel
metric,
“CP-score,”
devised
quantify
cuproptosis
response
patients.
Building
on
this,
prognostic
model,
CP-model,
developed
using
Cox
regression
techniques,
designed
operate
both
bulk
single-cell
data.
The
revealed
31
distinct
patterns
glioblastoma.
CP-score
markedly
elevated
patients,
suggesting
an
intensified
response.
CP-model
adeptly
stratified
patients
into
risk
categories,
unveiling
intricate
associations
prognosis,
immune
pathways,
tumor’s
immunological
environment.
Further
indicated
that
high-risk
as
per
exhibited
heightened
certain
checkpoints,
targets.
Additionally,
model
hinted
at
possibility
personalized
strategies,
drugs
showing
increased
efficacy
offers
promising
tool
for
strategy
development,
emphasizing
Cuproptosis
cancer
treatment.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Aug. 7, 2024
The
team
aimed
to
explore
the
possible
functional
significance
of
M6A
regulation
in
Pan-programmed
cell
death
(PCD)
among
patients
with
bladder
cancer
(BLCA).
In
BLCA
patients,
analysis
was
conducted
on
the13
patterns
programmed
and
M6A.
Transcriptome,
genomics,
clinical
data
were
collected
from
TCGA-BLCA,
GEO32548,
IMvigor210.
Consensus
clustering
analysis,
enrichment
other
prognostic
tools
used
validate
Pan-PCD.
Finally,
vitro
experiments
transcription
sequencing
performed
understand
potential
influence
PI3K
pathway
Pan-PCD
patients.
Diverse
PCD
simultaneously
activated,
regulators
exhibited
significant
variability
malignant
tissues.
machine
learning
algorithm
established
an
8-gene
M6A-related
signature.
This
signature
validated
three
independent
datasets,
higher
risk
scores
had
worse
prognosis.
An
unsupervised
approach
identified
activated
suppressed
subgroups
distinct
responses
immunotherapy
drug
sensitivity.
addition,
as
a
key
mechanism
for
various
forms
death,
encompassing
apoptosis,
pyroptosis,
autophagy,
dependent
lysosomes.
research
revealed
that
model
more
promising
under
regulation.
A
new
proposed,
value
survival
or
multiple
PCDs
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(13), P. e33795 - e33795
Published: June 28, 2024
Dysregulation
of
apoptosis
occurs
in
different
types
malignant
tumors
and
is
likely
to
influence
the
tumor
evolution,
as
well
clinical
prognosis.
However,
limited
number
studies
investigating
predictive
power
apoptosis-related
genes
(ARGs)
gastric
cancer
indicates
a
gap
current
research.
174
ARGs
who
differentially
expressed
were
screened
using
public
databases,
including
Gene
Expression
Omnibus
Molecular
Signatures
Database.
Univariate
LASSO
regression
analyses
rigorous
approaches
recognize
12
optimal
(
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
178, P. 117293 - 117293
Published: Aug. 14, 2024
Breast
cancer
is
one
of
the
most
prevalent
malignancies
among
women.
Enhancing
prognosis
an
effective
approach
to
enhance
survival
rate
breast
cancer.
Cuproptosis,
a
copper-dependent
programmed
cell
death
process,
has
been
associated
with
patient
prognosis.
Inducing
cuproptosis
promising
for
therapy.
However,
there
currently
no
anti-breast
drug
that
induces
cuproptosis.
In
this
study,
we
repositioned
clinical
fluphenazine
as
potential
agent
treatment
by
inducing
Firstly,
utilized
Cancer
Genome
Atlas
(TCGA)
database
and
Connectivity
Map
(CMap)
identify
22
compounds
activity
through
Subsequently,
our
findings
demonstrated
effectively
suppressed
viability
MCF-7
cells.
Fluphenazine
also
significantly
inhibited
triple
negative
cells
MDA-MB-453
MDA-MB-231.
Furthermore,
study
revealed
down-regulated
expression
prognostic
biomarkers
cuproptosis,
increased
copper
ion
levels,
reduced
intracellular
pyruvate
accumulation.
Additionally,
it
up-regulated
FDX1
at
both
mRNA
protein
which
reported
play
crucial
role
in
induction
These
suggest
be
used
Therefore,
research
provides
insight
development
novel
cuproptosis-dependent
anti-cancer
agents.
