Humoral Immune Response after COVID-19 mRNA Vaccination in Patients with Liver Cirrhosis: A Prospective Real-Life Single Center Study

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1320 - 1320

Published: April 28, 2023

Coronavirus-disease-2019 (COVID-19) mRNA vaccination effectively reduces mortality and morbidity in cirrhotic patients, but the immunogenicity safety of have been partially characterized. The study aimed to evaluate humoral response, predictive factors, mRNA-COVID-19 patients compared healthy subjects. A prospective, single-center, observational enrolled consecutive who underwent from April May 2021. Anti-spike-protein (anti-S) nucleocapsid-protein (anti-N) antibodies were evaluated before first (T0) second (T1) doses 15 days after completing vaccination. An age sex-matched reference group was included. incidence adverse events (AEs) assessed. In total, 162 enrolled, 13 excluded due previous SARS-CoV-2 infection; therefore, 149 Health Care Workers (HCWs) included analysis. seroconversion rate similar HCWs at T1 (92.5% vs. 95.3%, p = 0.44) T2 (100% both groups). At T2, anti-S-titres significantly higher (2776.6 1756 BAU/mL, < 0.001]. Male sex (β -0.32 [-0.64, -0.04], 0.027) past-HCV-infection -0.31 [-0.59, 0.029) independent predictors lower on multiple-gamma-regression-analysis. No severe AEs occurred. COVID-19-mRNA induces a high immunization patients. past-HCV infection are associated with anti-S-titres. is safe.

Language: Английский

Long-term antibody response after the third dose of inactivated SARS-CoV-2 vaccine in MASLD patients

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Sept. 30, 2024

Language: Английский

Safety and Efficacy of SARS-CoV-2 Vaccines in Patients With Chronic Liver Diseases: A Systematic Review and Meta-Analysis

International Journal of Public Health, Journal Year: 2024, Volume and Issue: 69

Published: Nov. 21, 2024

This review aimed to assess the safety and efficacy of SARS-CoV-2 vaccines in patients with chronic liver disease (CLD).

Language: Английский