Modifications of miRNAs in intervertebral disc degeneration: a key to the future development of genetic-based therapies DOI
Fariborz Ghaffarpasand, Sirous Sarhadi, Mohammad Hesam Alavi

et al.

Epigenomics, Journal Year: 2023, Volume and Issue: 15(5), P. 271 - 281

Published: March 1, 2023

Intervertebral disc degeneration (IDD) is the main cause of low back pain, which a healthcare concern associated with high social and economic burden. The current medical surgical therapies are inadequate ineffective. Several miRNAs have been identified that modulate (via up- or down-regulation) pathogenesis IDD through various signaling pathways. Understanding nature this regulation their pathways will enable researchers to manipulate miRNA develop miRNA-based therapies. development opens future window decrease process regenerate intervertebral disc. In near future, obstacles be overcome these move from bench bedside.

Language: Английский

Exosomal hsa-miR-335-5p and hsa-miR-483-5p are novel biomarkers for rheumatoid arthritis: A development and validation study DOI
Yeuni Yu,

Sohee Park,

Hansong Lee

et al.

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 120, P. 110286 - 110286

Published: May 20, 2023

Language: Английский

Citations

14
Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012 DOI Creative Commons
Junping Yang, Zehong Wei,

Huaiyu Li

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(9), P. e30555 - e30555

Published: May 1, 2024

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to progressive joint damage. Circular RNA (circRNA) can regulate the response of fibroblast-like synoviocytes (FLSs) in RA, influencing progression. Paeoniflorin (PF) main active ingredient extracted from Paeonia lactiflora and known for its anti-inflammatory effect. This study aims explore potential mechanisms by which hsa_circ_009012 PF RA.

Language: Английский

Citations

5
Cartilage-targeting fluorophores for early detection of arthritis in the NIR-II window DOI
Homan Kang, Seung Hun Park,

Guliz Ersoy Ozmen

et al.

Chem, Journal Year: 2025, Volume and Issue: unknown, P. 102481 - 102481

Published: March 1, 2025

Language: Английский

Citations

0
CD20, CTLA4, CXCL9, IL18RAP, IL-6, SOCS2, and TNF as potential biomarkers for rheumatoid arthritis disease progression: systematic review of RNA-seq studies DOI Creative Commons
Jairo Javier Jattin Balcázar, Daniel Sánchez,

Gerardo Quintana López

et al.

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e43108 - e43108

Published: March 1, 2025

Language: Английский

Citations

0
Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012 DOI Creative Commons
Junping Yang, Zehong Wei,

Huaiyu Li

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 3, 2024

Abstract Background Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to progressive joint damage. Circular RNAs (circRNAs) can regulate the response of fibroblast-like synoviocytes (FLSs) in rheumatoid and influence progression. Paeoniflorin (PF) main active ingredient extracted from Paeonia lactiflora Pallas known for its anti-inflammatory effect. This study aims explore potential mechanisms by which hsa_circ_009012 PF RA. Methods RNA expression hsa_circ_009012, has-microRNA-1286 (miR-1286), toll-like receptor 4 (TLR4), NOD-like thermal protein domain associated 3 (NLRP3) were assessed real-time quantitative polymerase chain reaction (RT-qPCR) or western blotting (WB). Cell inflammation markers (TNF-α, IL-1β, IL-6) RT-qPCR immunofluorescence (IF). Counting Kit-8 (CCK-8) assay, flow cytometry, transwell assay utilized test cell viability, cycle distribution, migration. Results Hsa_circ_009012 was highly expressed RA-FLSs. overexpression facilitated RA-FLSs closely with miR-1286/TLR4 axis. inhibited TLR4, while upregulating miR-1286 Moreover, upregulation reversed repressive effect paeoniflorin on Conclusion inhibits via mediating hsa_circ_009012/miR-1286/TLR4/NLRP3

Language: Английский

Citations

3
Current situation and trend of non-coding RNA in rheumatoid arthritis: a review and bibliometric analysis DOI Creative Commons
Zehong Wei,

Huaiyu Li,

Senhao Lv

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects multiple joints and has adverse effects on various organs throughout the body, often leading to poor prognosis. Recent studies have shown significant progress in research of non-coding RNAs (ncRNAs) RA. Therefore, this study aims comprehensively assess current status trends ncRNAs RA through bibliometric analysis. Methods This retrieved articles relevant from Science Citation Index Expanded Database Web Core Collection between January 1st, 2003, July 31st, 2023. The were screened based inclusion criteria. VOSviewer CiteSpace are utilized for visual Results A total 1697 publications included study, there was noticeable increase annual China, United States, Kingdom most productive countries field, contributing 43.81%, 13.09%, 3.87% publications. Anhui Medical University Lu Qianjin identified as influential institution author. Frontiers In Immunology stood out prolific journal, while Arthritis & Rheumatology co-cited journal. Additionally, related “circular RNA”, “oxidative stress”, “proliferation”, “migration” emerged new hotspots field. Conclusion we summarized publication characteristics ncRNA countries, institutions, authors, journals, hot topics, trends.

Language: Английский

Citations

2
Emerging roles of SnoRNAs in the pathogenesis and treatment of autoimmune disorders DOI
Gaurav Dubey, Mithilesh Singh, Himmat Singh

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 253, P. 154952 - 154952

Published: Nov. 19, 2023

Language: Английский

Citations

6
Role of Cathepsin G in Rheumatoid Arthritis Diagnosis and Disease Activity Evaluation DOI Creative Commons

Mays Saleh Khamees,

Raad Abdulameer Alasady

Kufa Medical journal, Journal Year: 2024, Volume and Issue: 20(1), P. 168 - 181

Published: June 15, 2024

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects 1% of the world's population. It causes inflammation synovial tissue, leading to joint destruction, poor quality life, and disability. Cathepsin G (CTSG), which acts as proteolytic enzyme, can be factor in RA. These proteases belong serine protease family have role disorders. They cause bone cartilage destruction an immune response cases inflammatory arthritis. The objective this study determine if CTSG could serve potential biomarker for diagnosis evaluation activity Methods: involved 132 patients with arthritis, their serum levels anti-citrullinated peptide antibody (ACPA) were measured using ELISA. Other routine biomarkers, including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid (RF), also measured. Results: mean was significantly lower RA (110.53 pg/ml ± 49.959) than those other types (132.65 30.199). According DAS-28 ESR CRP, found no significant difference across four groups (P = 0.585, P 0.823, respectively). Additionally, had negative correlation diabetes mellitus treatment intake newly diagnosed 0.009, 0.041, This first evaluate diagnostic tool, showing sensitivity 70.1% specificity 60.0% at cut-off value ≤133.33 pg/ml. Conclusions: results suggest has when used alongside clinical laboratory criteria. However, it should not solely relied upon evaluating activity.

Language: Английский

Citations

1
High serum levels of inflammatory markers are associated with early recurrence in patients with high-grade serous ovarian cancer after platinum therapy DOI

Bogna Brzezinska,

David Mysona,

Katherine P. Richardson

et al.

Gynecologic Oncology, Journal Year: 2023, Volume and Issue: 179, P. 1 - 8

Published: Oct. 19, 2023

Language: Английский

Citations

2
DENV-1 Infection of Macrophages Induces Pyroptosis and Causes Changes in MicroRNA Expression Profiles DOI Creative Commons
Qinyi Zhang,

Sicong Yu,

Zhangnv Yang

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2752 - 2752

Published: Nov. 30, 2024

Background: Dengue virus (DENV) is the most widespread mosquito-borne virus, which can cause dengue fever with mild symptoms, or progress to fatal hemorrhagic and shock syndrome. As main target cells of DENV, macrophages are responsible for innate immune response against virus. Methods: In this study, we investigated role pyroptosis in pathogenic mechanism by examining level DENV-1-infected further screened differentially expressed microRNAs high-throughput sequencing predict that could affect macrophage. Results: Macrophages infected DENV-1 were induced decreased cell viability, release lactate dehydrogenase IL-1β, activation NLRP3 inflammasome caspase-1, cleavage GSDMD produce an N-terminal fragment bound membrane, finally macrophage pyroptosis. MicroRNA expression profiles obtained from all periods infection comparing negative control. Sixty-three both early later stages also identified. particular, miR-223-3p, miR-148a-3p, miR-125a-5p, miR-146a-5p miR-34a-5p recognized as small molecules may be involved regulation inflammation. Conclusions: summary, study aimed understand DENV through relevant molecular mechanisms provide new targets dengue-specific therapy.

Language: Английский

Citations

0