Ocular Immunology and Inflammation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 5
Published: Sept. 13, 2024
To investigate the association of hypoxia-inducible factor-1α (HIF-1α), Janus tyrosine kinase-signal transducer and activator transcription (JAK-STAT) gene polymorphisms with idiopathic scleritis in a Chinese Han population.
Language: Английский
Cells, Journal Year: 2024, Volume and Issue: 13(2), P. 142 - 142
Published: Jan. 12, 2024
Background and aims: Inflammatory bowel diseases (IBD) are multifactorial chronic inflammatory disorders affecting the gastrointestinal tract. However, a broad spectrum of extraintestinal manifestations (EIMs) is associated with IBD, several organs systems, such as skin, musculoskeletal hepatobiliary and, not least, eye. Approximately 10% IBD patients can develop ocular EIMs (O-EIMs) higher prevalence in Crohn’s disease (CD). Eye-redness, photophobia, pain, blurred vision common symptoms, wide rate severity clinical impact on quality life. This narrative review aims to summarize prevalence, pathogenesis, current evidence-based management O-EIMs, underlying importance holistic approach specialties collaboration for prompt diagnosis treatment. Methods: PubMed was searched up December 2023 identify relevant studies investigating epidemiology, treatment O-EIMs patients. Results: The mechanisms partially unknown, encompassing immune dysregulation, shared antigens between eye gut, genetic predisposition, systemic inflammation driven by high levels interleukins cytokines complexity O-EIMs’ pathogenesis reflects these conditions, varying from topical steroids immunomodulatory molecules biologic therapy, anti-tumor necrosis factor (TNF)-alpha. A multidisciplinary backbone O-EIMs.
Language: Английский
Citations
6
Advances in Ophthalmology and Optometry, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Citations
0
Klinische Monatsblätter für Augenheilkunde, Journal Year: 2024, Volume and Issue: 241(05), P. 626 - 632
Published: April 4, 2024
Zusammenfassung Okuläre Manifestationen rheumatischer Erkrankungen sind häufig und tragen wesentlich zur Morbidität Reduktion der Lebensqualität betroffenen Patienten bei. Die Kenntnis über typische Manifestationsformen ist bedeutsam für den Rheumatologen, um mit entsprechender Symptomatik frühzeitig ophthalmologisch vorstellen zu können oder auch regelmäßige Screeninguntersuchungen veranlassen (z. B. bei Behçet-Syndrom). Umgekehrt eine (ggf. dringliche) rheumatologische Mitbeurteilung bestimmten ophthalmologischen Krankheitsbildern entscheidend, (u. U. letale) systemische assoziierte Erkrankung nicht übersehen. rheumatischen bzw. entzündlichen okulären sollten immer durch behandelnden Arzt mögliche Symptome anderweitiger Organmanifestationen aufgeklärt werden, verzögerte Diagnosestellung vermeiden. „Klassische“ Assoziationen Uveitiden die (HLA-B27-assoziierten) Spondyloarthritiden akute anteriore Uveitis sowie retinale Vaskulitis ohne Panuveitis das Behçet-Syndrom. Bei rheumatoider Arthritis ANCA-assoziierten Vaskulitiden hingegen treten typischerweise Skleritiden (mit periphere ulzerative Keratitis) auf, aber Vielzahl weiterer Befunde möglich. enge interdisziplinäre Zusammenarbeit insbesondere in Therapiegestaltung gute Prognose sichern.
Citations
1
Expert Review of Ophthalmology, Journal Year: 2024, Volume and Issue: 19(5), P. 357 - 377
Published: July 19, 2024
Introduction Necrotizing scleritis is more likely to be associated with severe pain, poor visual outcomes, increased mortality, and autoimmune disease such as rheumatoid arthritis. The advent of targeted biologic therapy has revolutionized the treatment rheumatic diseases, these medications are currently being explored for ocular inflammatory – including necrotizing scleritis, which often refractory conventional immunomodulatory therapies.
Language: Английский
Citations
0
Ocular Immunology and Inflammation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 5
Published: Sept. 13, 2024
To investigate the association of hypoxia-inducible factor-1α (HIF-1α), Janus tyrosine kinase-signal transducer and activator transcription (JAK-STAT) gene polymorphisms with idiopathic scleritis in a Chinese Han population.
Language: Английский
Citations
0