International Journal of Geriatrics and Gerontology,
Journal Year:
2023,
Volume and Issue:
7(1)
Published: Nov. 20, 2023
Abstract
Introduction:
The
increasing
prevalence
of
dementia
and
mild
cognitive
impairment
is
a
priority
for
health
systems
society
in
the
coming
years.
aim
this
study
was
to
provide
an
overview
good
clinical
practices,
barriers,
gaps
integrated
care.
Methods:
An
electronic
search
conducted
on
PubMed
database
last
five
years
articles
relevant
scope
study,
humans,
written
Portuguese
or
English,
open
access.
National
international
guidelines
consensus
documents
recognized
Europe
were
also
included.
Results:
With
life
expectancy
aging
as
major
risk
factors,
number
people
living
with
will
become
unsustainable
medical,
social,
informal
Ineffective
care
pathways
lead
unnecessary
medical
interventions
suboptimal
People
should
be
involved
all
stages
research.
High-quality
epidemiological
data
by
disease
severity
subtype
are
needed.
development
novel
technologies
improve
assessment
cognition
function
that
sensitive
accurate
early
can
used
primary
unmet
need.
A
strategy
from
diagnosis
end
lacking.
Research
into
effective
models
new
treatment
more
selection
patients
crucial.
Conclusions:
There
currently
several
Integrated
pathways,
patient-centered
approaches,
establishment
workforce
based
comprehensive
pragmatic
framework
priorities
included
public
strategies.
Journal of Alzheimer s Disease,
Journal Year:
2024,
Volume and Issue:
99(4), P. 1159 - 1171
Published: June 7, 2024
The
link
between
long
COVID-19
and
brain/cognitive
impairments
is
concerning
may
foster
a
worrisome
worldwide
emergence
of
novel
cases
neurodegenerative
diseases
with
aging.
This
review
aims
to
update
the
knowledge,
crosstalk,
possible
intersections
Post-COVID
Syndrome
(PCS)
Alzheimer’s
disease
(AD).
References
included
in
this
were
obtained
from
PubMed
searches
conducted
October
2023
November
2023.
PCS
very
heterogenous
poorly
understood
recent
evidence
association
chronic
such
as
AD.
However,
more
scientific
data
required
establish
Current Nutrition & Food Science,
Journal Year:
2024,
Volume and Issue:
20(10), P. 1177 - 1188
Published: Feb. 1, 2024
:
Cognition
includes
all
phases
of
valid
functions
and
processes,
e.g.,
sensitivity,
judgment,
assessment,
decision-making.
Thinking
is
also
a
cognitive
procedure
since
it
involves
considering
potential
opportunities.
There
are
various
types
cognition.
Hot
cognition
mental
procedures
where
emotion
plays
role,
while
cold
processes
that
do
not
include
feelings
or
emotions.
Cognitive
memories
sensor
memory,
sensing
touch,
smell,
sight;
short-term
memory
allows
one
to
recall,
what
had
for
lunch
few
days
ago;
working
remembering
telephone
numbers
directions
destination;
long-term
comprises
major
milestones
in
life
recalling
one’s
childhood
events.
These
further
classified
as
episodic,
the
first
day
primary
school,
semantic
memories,
such
capital
city
country
filling
out
crossword
puzzles.
Declarative
significant
past
events,
global
information.
affected
by
factors,
nutrition,
aging,
addiction,
environment,
health,
physical
activity,
smoking,
keeping
brain
active.
Consumption
plant-
based
foods
prominent
role
prevention
memory.
Playing
games
instruments,
reading
books,
being
socially
active
make
more
satisfying,
thus
assisting
preservation
function
slowing
decline.
Clinical Phytoscience,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: Feb. 4, 2024
Abstract
Backgrounds:
Artocarpus
altilis
(breadfruit)
belongs
to
the
family
Moraceae.
possesses
antioxidative,
anti-inflammatory,
and
anti-proliferative
properties.
Aluminum
(Al)
is
extensively
utilized
for
consumer
products,
cooking
utensils,
pharmaceuticals,
industries.
Indication
neurotoxicity
of
Al
investigated
in
various
studies,
notwithstanding
precise
mechanisms
toxicity
are
yet
be
fully
elucidated,
and,
which
requires
novel
therapy.
In
this
study,
we
determined
ameliorative
role
on
aluminum
chloride-induced
Drosophila
melanogaster
.
Methods
Varying
concentration
extract
were
used
formulate
diets
6
groups
flies.
Group
1
contained
basal
diet,
group
2
diet
aluminium
chloride
(AlCl
3
),
+
0.1%
unseeded
breadfruit
(UBF),
4
1%
breadfruit,
5
AlCl3
breadfruit.
Assays
such
as
acetylcholinesterase
activity,
malondialdehyde
(MDA)
level,
catalase
superoxide
dismutase
(SOD)
activity
carried
out
after
7
days
exposure
respectively.
Results
The
results
showed
low
MDA
level
high
SOD
pretreated
post-treated
flies
with
compared
normal
negative
control
Conclusions
Taken
together,
a
promising
prophylactic,
antiacetylcholinesterase,
antioxidant
plant
prevention,
management
treatment
neurodegenerative
diseases.
Graphical
GeroScience,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 29, 2024
Post-COVID
syndrome
manifests
with
numerous
neurological
and
cognitive
symptoms,
the
precise
origins
of
which
are
still
not
fully
understood.
As
females
older
adults
more
susceptible
to
developing
this
condition,
our
study
aimed
investigate
how
post-COVID
alters
intrinsic
brain
dynamics
in
whether
biological
sex
training
might
modulate
these
effects,
a
specific
focus
on
females.
The
participants,
aged
between
60
75
years,
were
divided
into
three
experimental
groups:
healthy
old
female,
female
male.
They
underwent
an
adaptive
task-switching
protocol.
We
analysed
multiscale
entropy
spectral
power
density
resting-state
EEG
data
collected
before
after
assess
neural
signal
complexity
oscillatory
power,
respectively.
found
no
difference
males
training,
indicating
that
similarly
affected
both
sexes.
However,
was
effective
only
males,
by
modulating
local
processing
capacity.
This
improvement
further
evidenced
comparing
females,
wherein
latter
group
showed
increased
finer
timescale
(1-30
ms)
higher
frequency
band
(11-40
Hz)
but
differences
disappeared
following
training.
Our
results
suggest
syndrome,
there
is
pronounced
shift
from
global
processing,
potentially
contributing
accelerated
aging
condition.
seems
offer
promising
intervention
method
for
changes
dynamics,
especially
among
Acta Naturae,
Journal Year:
2024,
Volume and Issue:
16(3), P. 51 - 59
Published: Nov. 12, 2024
Sporadic
Alzheimer’s
disease
(sAD)
is
the
most
common
of
neurodegenerative
disorders.
The
lack
effective
therapy
indicates
that
mechanisms
sAD
development
remain
poorly
understood.
To
investigate
this
pathology
in
animals,
intracerebroventricular
injection
β-amyloid
peptide
(Aβ)
using
a
Hamilton
syringe,
either
during
stereotactic
surgery
or
through
pre-implanted
cannula,
used.
In
study,
we
analyzed
effect
chronic
cannula
implantation
on
severity
Aβ
effects
at
behavioral,
histological,
and
biochemical
levels.
results
showed
local
damage
to
neural
tissue
caused
by
cannulation
has
no
bearing
animal
behavior
microglial
parameters
unilateral
hippocampus
two
weeks
after
administration.
However,
fundamentally
modifies
some
markers
oxidative
stress
occurs
brain
response
Thus,
presence
reduces
impact
levels
peroxidized
lipids
glutathione
two-
10-fold,
respectively.
It
important
note
detected
changes
are
systemic.
This
known
because
homogenate
entire
contralateral
(in
relation
site)
hemisphere
was
analyzed,
analysis
performed
implantation.
At
same
time,
does
not
affect
rate
reactive
oxygen
species
production.
obtained
data
indicate
into
experimental
animals
distorts
tissue,
which
widely
used
assess
Alzheimer’s-type
diseases.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(12), P. 2697 - 2697
Published: Nov. 29, 2023
Progesterone
(P4)
is
a
neuroactive
hormone
having
pleiotropic
effects,
supporting
its
pharmacological
potential
to
treat
global
(cardiac-arrest-related)
cerebral
ischemia,
condition
associated
with
an
elevated
risk
of
dementia.
This
review
examines
the
current
biochemical,
morphological,
and
functional
evidence
showing
neuroprotective/neurorestorative
effects
P4
against
ischemia
(GCI).
Experimental
findings
show
that
may
counteract
pathophysiological
mechanisms
and/or
regulate
endogenous
plasticity
induced
by
GCI.
According
this,
treatment
consistently
improves
performance
cognitive
functions,
such
as
learning
memory,
impaired
recovery
related
significant
morphological
preservation
brain
structures
vulnerable
when
administered
before
after
moderate
ischemic
episode;
long-term
adaptive
plastic
restoration
processes
altered
morphology
given
episode
severe
ischemia.
The
insights
presented
here
be
guide
for
future
basic
research,
including
study
administration
schemes
focus
on
promoting
post-ischemia
neurorestorative
effect.
Furthermore,
considering
desired
endpoint
strategies
in
clinic,
they
could
support
decreasing
dementia
patients
who
have
suffered
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: July 26, 2023
Abstract
COVID-19
induces
acute
and
long-term
neurological
symptoms.
Determining
the
mechanisms
underlying
disease
will
lead
to
a
better
understanding
of
long-COVID
late-onset
outcomes.
Here,
we
investigate
in
detail
cohort
patients
presenting
alterations.
Clinical
investigation,
brain
imaging,
bio-sample
analyses
were
carried
out.
We
tested
possibility
that
shares
molecular
links
with
Alzheimer’s
(AD)-like
neurodegeneration
by
analyzing
framework
ATN
(amyloid,
pathologic
Tau,
neurodegeneration)
biomarkers.
Altered
cerebrospinal
fluid
(CSF)
Tau
amyloid
levels
severe
comparable
amnestic
mild
cognitive
impairment
(aMCI)
AD
patients.
Increased
CSF
pro-inflammatory
cytokine
IL6
linked
systemic
inflammation
severity
central
nervous
system
presented
an
altered
proteomic
pattern,
inflammatory,
coagulopathy,
amyloidosis
pathways
Collectively,
our
findings
reveal
some
between
biomarkers
associated
AD.
International Journal of Geriatrics and Gerontology,
Journal Year:
2023,
Volume and Issue:
7(1)
Published: Nov. 20, 2023
Abstract
Introduction:
The
increasing
prevalence
of
dementia
and
mild
cognitive
impairment
is
a
priority
for
health
systems
society
in
the
coming
years.
aim
this
study
was
to
provide
an
overview
good
clinical
practices,
barriers,
gaps
integrated
care.
Methods:
An
electronic
search
conducted
on
PubMed
database
last
five
years
articles
relevant
scope
study,
humans,
written
Portuguese
or
English,
open
access.
National
international
guidelines
consensus
documents
recognized
Europe
were
also
included.
Results:
With
life
expectancy
aging
as
major
risk
factors,
number
people
living
with
will
become
unsustainable
medical,
social,
informal
Ineffective
care
pathways
lead
unnecessary
medical
interventions
suboptimal
People
should
be
involved
all
stages
research.
High-quality
epidemiological
data
by
disease
severity
subtype
are
needed.
development
novel
technologies
improve
assessment
cognition
function
that
sensitive
accurate
early
can
used
primary
unmet
need.
A
strategy
from
diagnosis
end
lacking.
Research
into
effective
models
new
treatment
more
selection
patients
crucial.
Conclusions:
There
currently
several
Integrated
pathways,
patient-centered
approaches,
establishment
workforce
based
comprehensive
pragmatic
framework
priorities
included
public
strategies.
