Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 9, 2023
Abstract
Objective
Recent
studies
indicate
that
dyslipidemia
could
be
a
critical
risk
factor
for
cardiovascular
disease
in
Takayasu
arteritis
(TA),
but
the
relationship
between
and
activity
of
TA
itself
is
unclear.
Methods
To
better
understand
connection
serum
lipid
profiles
patients,
this
study
assessed
presence
atherosclerosis
untreated
female
patients.
Fifty
patients
with
(median
age
30
years)
98
age-
BMI-matched
healthy
controls
were
enrolled.
The
profile
(TC,
TG,
HDL-C,
LDL-C,
ApoA1,
ApoB,
ApoE,
LPa),
inflammatory
markers
(CRP,
ESR)
carotid
atherosclerotic
plaque
frequency
evaluated.
Results
levels
nonHDL-C/HDL-C
significantly
higher
than
those
control
group,
while
TC,
HDL-c,
ApoA1
lower
group.
Spearman
correlation
analysis
showed
CRP
was
positively
correlated
nonHDL-C/HDL-C,
negatively
ApoA1.
Besides,
ESR
nonHDL-C,
Carotid
found
8
(14.3%)
Multivariate
regression
only
related
to
age,
not
nor
lipoproteins.
Conclusions
Overall,
implies
have
an
obvious
dysregulated
profile.
Moreover,
may
dyslipidemia,
supporting
hypothesis
young
also
disease.
Scandinavian Journal of Rheumatology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 9
Published: May 6, 2025
Recent
studies
suggest
that
dyslipidaemia
may
play
a
critical
role
in
the
progression
of
cardiovascular
disease
Takayasu
arteritis
(TA),
although
exact
relationship
between
and
TA
activity
remains
unclear,
which
is
focus
this
study.
We
evaluated
atherosclerosis
cohort
untreated
female
patients.
Fifty
patients
with
(median
age
30
years)
98
healthy
controls
matched
for
body
mass
index
were
assessed
lipid
profiles
[total
cholesterol
(TC),
triglycerides
(TG),
high-density
lipoprotein
(HDL-C),
low-density
(LDL-C),
apolipoprotein
A1
(ApoA1),
ApoB,
ApoE,
lipoprotein(a)],
inflammatory
markers
[C-reactive
protein
(CRP),
erythrocyte
sedimentation
rate
(ESR)],
atherosclerotic
plaque
frequency.
exhibited
significantly
higher
levels
TG
non-HDL-C/HDL-C
ratio
than
control
group,
whereas
TC,
HDL-C,
LDL-C,
ApoA1
lower.
Pearson's
correlation
analysis
indicated
positive
CRP
as
well
ratio,
negative
correlations
TG,
ApoA1.
Atherosclerotic
plaques
detected
14.3%
Multivariate
regression
revealed
presence
was
associated
only
age,
independent
levels.
The
results
study
indicate
exhibit
markedly
dysregulated
serum
profile.
Atherosclerosis
early
not
related
to
lipids
or
inflammation.
Journal of Investigative Dermatology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 1, 2025
Psoriasis
arises
from
a
combination
of
genetic
and
environmental
factors,
triggering
inflammatory
circuits
involving
innate
adaptive
immune
responses.
While
the
associated
histological
changes
are
well
described,
on
protein
level
with
inflammation
tissue
remodeling
have
only
been
characterized
to
limited
extent
low
degree
spatial
information.
Therefore,
we
aimed
explore
skin
layer-specific
proteomic
in
psoriatic
plaques.
Using
laser-capture
microdissection,
divided
biopsies
patients
psoriasis
(N=8)
healthy
controls
into
four
layers
(stratum
corneum,
inner
epidermis,
dermis,
subcutis)
analyzed
composition
each
layer
using
mass
spectrometry.
A
total
7,236
proteins
were
identified
1,649
differentially
expressed
lesional
versus
non-lesional
epidermis.
Several
upregulated
related
immunity
cholesterol
biosynthesis.
Stratum
corneum
showed
more
complex
lesions
compared
controls,
while
dermis
exhibited
upregulation
involved
IL-17
signaling
neutrophil
chemotaxis.
No
differences
detected
subcutis.
Our
findings
highlight
epidermis
as
central
pathology,
driven
by
both
mechanisms
that
potentially
enhanced
an
increased
production.
Journal of Medical Biochemistry,
Journal Year:
2023,
Volume and Issue:
43(1), P. 97 - 105
Published: July 31, 2023
Psoriasis
is
an
autoinflammatory
disease
that
affects
not
only
skin
but
multiple
organs
thus
being
associated
with
many
comorbidities.
Oxidative
stress
and
inflammation
play
the
major
role
in
pathogenesis
of
this
disease.
Studies
examined
by-products
oxidative
psoriasis
show
discrepant
results.
Hence,
we
aimed
to
examine
stress,
metabolic
markers
explore
their
potential
relationship
severity
patients
psoriasis.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(8), P. 912 - 912
Published: July 28, 2024
Psoriasis
is
a
chronic
inflammatory
disease
that
affects
around
2-3%
of
the
world's
population.
The
treatment
for
this
autoimmune
still
remains
centered
conventional
methods
using
synthetic
substances,
even
though
more
recent
advancements
focus
on
biological
therapies.
Given
numerous
side
effects
such
treatments,
current
research
involves
plant
extracts
and
constituents
could
prove
useful
in
treating
psoriasis.
aim
narrative
review
to
highlight
most
known
representatives
belonging
classes
natural
compounds
as
polyphenols
(e.g.,
astilbin,
curcumin,
hesperidin,
luteolin,
proanthocyanidins,
resveratrol),
alkaloids
berberine,
capsaicin,
colchicine),
coumarins
(psoralen
8-methoxypsoralen),
terpenoids
celastrol,
centelloids,
ursolic
acid),
along
with
plants
used
traditional
medicine
present
therapeutic
potential
paper
also
provides
an
overview
these
compounds'
mechanisms
action
inclusion
clinical
studies,
well
investigation
into
their
incorporation
various
nanotechnological
systems,
lipid-based
nanocarriers
or
polymeric
nanomaterials,
may
optimize
efficacy
during
treatment.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(21), P. 4563 - 4563
Published: Oct. 27, 2023
Fatigue
and
musculoskeletal
pain
are
also
frequent
in
patients
with
psoriasis
(PsO)
without
arthritis
(PsA).
The
current
study
aimed
to
assess
the
impact
of
an
intervention
program
based
on
aerobic
training
reduce
fatigue
PsO
PsA.
A
total
118
male
volunteered
interventional
were
randomly
allocated
experimental
(n
=
59)
or
control
group
59).
consisted
a
16-week
treadmill,
three
sessions
per
week,
consisting
warm-up,
35-50
min
treadmill
exercise
(increasing
5
min/4
weeks)
at
work
intensity
50-65%
peak
heart-rate
5%/4
weeks),
cooling-down.
functional
assessment
chronic
illness
therapy
scale
(FACIT-Fatigue),
health
questionnaire
disability
index
(HAQ-DI),
visual
analog
(VAS)
compared
pre
post
intervention.
Nutritional
intake,
maximal
power,
lipid
profile,
serum
markers
muscle
damage,
body
composition
assessed.
When
baseline,
FACIT-Fatigue,
HAQ-DI,
VAS
scores
significantly
improved
increasing
damage.
Fat
mass
percentage,
oxygen
consumption
improved.
In
conclusion,
moderate
was
safe,
well
tolerated,
effective
psoriatic
Long-term
follow-up
studies
required
examine
whether
these
promising
results
may
improve
clinical
outcomes.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 25, 2024
Abstract
Leprosy
and
psoriasis
rarely
coexist,
the
specific
molecular
mechanisms
underlying
their
mutual
exclusion
have
not
been
extensively
investigated.
This
study
aimed
to
reveal
mechanism
responsible
for
between
leprosy.
We
obtained
leprosy
data
from
ArrayExpress
GEO
database.
Differential
expression
analysis
was
conducted
separately
on
using
DEseq2.
Differentially
expressed
genes
(DEGs)
with
opposite
patterns
in
were
identified,
which
could
potentially
involve
exclusion.
Enrichment
performed
these
candidate
mutually
exclusive
genes,
a
protein–protein
interaction
(PPI)
network
constructed
identify
hub
genes.
The
of
further
validated
an
external
dataset
obtain
critical
Additionally,
immune
cell
infiltration
analyzed
single-sample
gene
set
enrichment
(ssGSEA),
correlation
cells
also
examined.
Finally,
pattern
evaluated
single-cell
transcriptome
dataset.
identified
1098
DEGs
3839
48
by
taking
intersection.
revealed
that
involved
cholesterol
metabolism
pathways.
Through
PPI
analysis,
we
APOE,
CYP27A1,
FADS1,
SOAT1
as
subsequently
both
internal
datasets.
Analysis
indicated
higher
abundance
16
types
compared
normal
controls.
6
positively
correlated
levels
APOE
CYP27A1.
Single-cell
demonstrated
predominantly
Schwann
fibroblasts.
Cholesterol
pathway
illustrated
possible
inverse
association
findings
this
provide
basis
identifying
therapeutic
targets
psoriasis.
Parasite Immunology,
Journal Year:
2024,
Volume and Issue:
46(5)
Published: May 1, 2024
ABSTRACT
Apolipoprotein
E
(ApoE)
has
been
associated
with
several
diseases
including
Parkinson's
disease,
Alzheimer's
and
multiple
sclerosis.
ApoE
also
documented
immunomodulatory
functions.
We
investigated
gene
expression
in
circulating
monocytes
bone
marrows
of
patients
visceral
leishmaniasis
(VL)
living
an
endemic
area
Bihar,
India,
contrasted
these
control
healthy
subjects
or
other
diagnostic
from
individuals
the
same
region.
Samples
VL
were
obtained
prior
to
initiating
treatment.
Our
study
revealed
significant
upregulated
apoE
transcript
VL.
Furthermore,
levels
protein
elevated
serum
samples
compared
controls.
These
observations
may
provide
clues
regarding
complex
interactions
between
lipid
metabolism
immunoregulation
infectious
inflammatory
diseases.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: June 9, 2023
Abstract
Objective
Recent
studies
indicate
that
dyslipidemia
could
be
a
critical
risk
factor
for
cardiovascular
disease
in
Takayasu
arteritis
(TA),
but
the
relationship
between
and
activity
of
TA
itself
is
unclear.
Methods
To
better
understand
connection
serum
lipid
profiles
patients,
this
study
assessed
presence
atherosclerosis
untreated
female
patients.
Fifty
patients
with
(median
age
30
years)
98
age-
BMI-matched
healthy
controls
were
enrolled.
The
profile
(TC,
TG,
HDL-C,
LDL-C,
ApoA1,
ApoB,
ApoE,
LPa),
inflammatory
markers
(CRP,
ESR)
carotid
atherosclerotic
plaque
frequency
evaluated.
Results
levels
nonHDL-C/HDL-C
significantly
higher
than
those
control
group,
while
TC,
HDL-c,
ApoA1
lower
group.
Spearman
correlation
analysis
showed
CRP
was
positively
correlated
nonHDL-C/HDL-C,
negatively
ApoA1.
Besides,
ESR
nonHDL-C,
Carotid
found
8
(14.3%)
Multivariate
regression
only
related
to
age,
not
nor
lipoproteins.
Conclusions
Overall,
implies
have
an
obvious
dysregulated
profile.
Moreover,
may
dyslipidemia,
supporting
hypothesis
young
also
disease.
