Bibliometric analysis and visualization of the research on the relationship between RNA methylation and immune cell infiltration in tumors DOI Creative Commons

Sibo Meng,

Guanghui Yang,

Enhao Yu

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 12, 2024

Background This research endeavors to delve into the hotspots and trends concerning RNA methylation tumor immune cells through application of bibliometric analysis visualization techniques. Methods A comprehensive search in WoSCC (2014-2023) for cell articles/reviews was conducted. Bibliometric employed CiteSpace, Bibliometric, VOSviewer tools. Results total 3295 articles were included analysis, with a continuously increasing number publications linking tumoral cells. Chinese authors institutions have demonstrated sustained growth trend both author influence. SUN YAT SEN UNIVERSITY, institution, has published highest this field, while also demonstrating extensive international inter-institutional collaborations. Meanwhile, HARVARD UNIVERSITY achieved impressive results. For instance, Frontiers Immunology largest category. Nature Communications that are most influential playing pivotal role disseminating findings. The vitality field is attributed its solid foundation, including groundbreaking work by Professor Chiappinelli KB Cell widely cited paper Han DL Nature. Analysis topics reveals m5C, immunotherapy, microenvironment current focuses. Conclusion Future investigative efforts at juncture anticipated concentrate on domains n7-methylguanosine, cuproptosis, prognosis assessment, immunotherapeutic strategies, microenvironment.

Language: Английский

The role of RNA methylation in tumor immunity and its potential in immunotherapy DOI Creative Commons
Yan Li,

Haoer Jin,

Qingling Li

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 20, 2024

Abstract RNA methylation, a prevalent post-transcriptional modification, has garnered considerable attention in research circles. It exerts regulatory control over diverse biological functions by modulating splicing, translation, transport, and stability. Notably, studies have illuminated the substantial impact of methylation on tumor immunity. The primary types encompass N6-methyladenosine (m6A), 5-methylcytosine (m5C), N1-methyladenosine (m1A), N7-methylguanosine (m7G), 3-methylcytidine (m3C). Compelling evidence underscores involvement regulating microenvironment (TME). By affecting translation stability through "writers", "erasers" "readers", influence dysregulation immune cells factors. Consequently, plays pivotal role immunity mediating various behaviors, encompassing proliferation, invasion, metastasis, etc. In this review, we discussed mechanisms several methylations, providing comprehensive overview their roles underlying within among immunocytes. exploring how these modifications mediate evasion, also examine potential applications immunotherapy. This review aims to provide novel insights strategies for identifying targets advancing cancer immunotherapy efficacy.

Language: Английский

Citations

32
Emerging role of RNA acetylation modification ac4C in diseases: Current advances and future challenges DOI
Jie Luo, Jingsong Cao, Cong Chen

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 213, P. 115628 - 115628

Published: May 27, 2023

Language: Английский

Citations

35
Targeting aryl hydrocarbon receptor to prevent cancer in barrier organs DOI Creative Commons

Francoise Congues,

Pengcheng Wang, Joshua K. Lee

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 223, P. 116156 - 116156

Published: March 20, 2024

The skin, lung, and gut are important barrier organs that control how the body reacts to environmental stressors such as ultraviolet (UV) radiation, air pollutants, dietary components, microorganisms. aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor plays an role in maintaining homeostasis of organs. AhR was initially discovered for chemical carcinogens polycyclic aromatic hydrocarbons (PAHs). Activation pathways by PAHs leads increased DNA damage mutations which ultimately lead carcinogenesis. Ongoing evidence reveals ever-expanding AhR. Recently, has been linked immune systems interaction with development natural killer (NK) cells, regulatory T (T

Language: Английский

Citations

12
RNA research for drug discovery: Recent advances and critical insight DOI
Patrick Maduabuchi Aja, Peter Chinedu Agu, Celestine O. Ogbu

et al.

Gene, Journal Year: 2025, Volume and Issue: 947, P. 149342 - 149342

Published: Feb. 19, 2025

Language: Английский

Citations

1
The m6A revolution: transforming tumor immunity and enhancing immunotherapy outcomes DOI Creative Commons
Tongguo Shi, Huan Zhang, Yueqiu Chen

et al.

Cell & Bioscience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 22, 2025

Abstract N6-methyladenosine (m6A), the most prevalent RNA modification in eukaryotes, plays a critical role development and progression of various diseases, including cancer, through its regulation degradation, stabilization, splicing, cap-independent translation. Emerging evidence underscores significant m6A modifications both pro-tumorigenic anti-tumorigenic immune responses. In this review, we provide comprehensive overview examine relationship between regulators cancer Additionally, summarize recent advances understanding how influence tumor responses by directly modulating cells (e.g., dendritic cells, tumor-associated macrophages, T cells) indirectly affecting via mechanisms such as cytokine chemokine regulation, modulation cell surface molecules, metabolic reprogramming. Furthermore, explore potential synergistic effects targeting combination with checkpoint inhibitor (ICI) therapies. Together, review consolidates current knowledge on m6A-mediated immunity, offering insights into deeper these may identify patients who are likely to benefit from immunotherapies.

Language: Английский

Citations

1
METTL3 facilitates prostate cancer progression via inducing HOXC6 m6A modification and stabilizing its expression through IGF2BP2-dependent mechanisms DOI

Peng He,

Xuehui Liu, Yu Gui

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(7), P. 1707 - 1720

Published: May 31, 2024

Language: Английский

Citations

4
m6A eraser ALKBH5/treRNA1/DDX46 axis regulates BCR expression DOI
Bandish Kapadia, Anirban Roychowdhury,

Forum Kayastha

et al.

Neoplasia, Journal Year: 2025, Volume and Issue: 62, P. 101144 - 101144

Published: Feb. 22, 2025

Language: Английский

Citations

0
Genetic Insights into Breast Cancer in Northeastern Mexico: Unveiling Gene–Environment Interactions and Their Links to Obesity and Metabolic Diseases DOI Open Access
Hugo L. Gallardo‐Blanco, María Lourdes Garza-Rodríguez, Diana Cristina Pérez-Ibave

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(6), P. 982 - 982

Published: March 14, 2025

Background: Breast cancer (BC), one of the most common cancers, has increased in Mexico during past decade, along with other chronic and metabolic diseases. Methods: Herein, we analyzed 121 SNPs (85 related to BC and/or glucose-associated pathways 36 SNP classified as ancestry markers) 92 confirmed cases 126 unaffected women from Northeastern Mexico. The relationship these BC, considering BMI, menopause status, age cofactors, was explored using a gene–environment (G × E) interaction multi-locus model. Results: Twelve gene variants were significantly associated BC: three located exome (rs3856806 PPARG, rs12792229 MMP8, rs5218 KCNJ11-ABCC8), nine non-coding regions, which are involved accelerated decay mRNA transcripts, regulatory flanking regions (rs3917542 PON1; rs3750804 rs3750805 TCF7L2; rs1121980 rs3751812 FTO; rs12946618 RPTOR; rs2833483 SCAF4; rs11652805 AMZ2P1-GNA13; rs1800955 SCT-DEAF1-DRD4). Conclusions: This study identified an association between menopause, (above 45), obesity, overweight status implicated diabetes mellitus, insulin resistance, inflammation, remodeling extracellular matrix.

Language: Английский

Citations

0
The Role of M6A LncRNA Modification in Papillary Thyroid Cancer DOI Open Access

Michelle S. Klausner,

Caylee A. Greenberg, Kaleb Noruzi

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2833 - 2833

Published: March 21, 2025

Thyroid Cancer (TC) is the most common endocrine cancer, of which papillary thyroid cancer (PTC), a well-differentiated type TC, accounts for 80–90%. Long non-coding RNAs (lncRNAs), comprise non-protein-coding segments genome, have been found to play crucial role in various biological processes, including development. The activity lncRNAs modified through epigenetic modifications, with N6-Methyladenosine (m6A) modifications implicated progression several malignancies. m6A further regulated by modifying enzymes classified as “readers”, writers”, and “erasers”, specific aspects PTC. Recent research has highlighted significance modification regulating expression function associated PTC pathogenesis. Dysregulation this process implicates tumor proliferation, invasion, metastasis, subsequent impact on prognosis. Therefore, understanding interplay between provides valuable insights into molecular mechanisms underlying progression. This narrative review aims explore established prominent pathogenesis seeks clarify these

Language: Английский

Citations

0
Identification of m6 A-regulated ferroptosis biomarkers for prognosis in laryngeal cancer DOI Creative Commons
Xin Wang, Wen Zhang, Kun Liang

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 14, 2025

Laryngeal cancer (LC) is a malignant tumor that occurs in the larynx. N6-methyladenosine (m6A) RNA methylation, pivotal and prevalent epigenetic modification eukaryotic mRNA, intricately intertwines with ferroptosis, together, they play crucial role development of LC. Accordingly, further research on related molecular mechanisms pathology LC necessary. Weighted gene co-expression network analysis correlation were used to identify differentially expressed m6A-related ferroptosis genes The TCGA-HNSC GSE65858 datasets obtained from public databases. dataset consisted 110 primary oropharynx samples 12 control samples, while contained forty-eight samples. Univariate Cox least absolute shrinkage selection operator (LASSO) regression utilized for feature risk model construction dataset. was validated Then, nomogram built based independent prognostic factor identified using univariate multivariate Mutation analysis, immune-related drug sensitivity prediction applied analyze utility Additionally, qRT-PCR western blot performed detect TFRC, RGS4, FTH1 expression. Three biomarkers build LASSO algorithms. Receiver operating characteristic (ROC) verified accuracy model. Tumor Immune Dysfunction Exclusion (TIDE) Estimation STromal cells MAlignant Tumors Expression data (ESTIMATE) algorithm showed positive relationship between score TIDE or ESTIMATE score. Furthermore, found 19 chemotherapy drugs strongly correlated exhibited high expression levels 30 laryngeal carcinoma tissues cell lines. Notably, TFRC significantly associated patient prognosis. In Conclusion, FTH1, as m6A-regulated LC, providing insights into treatment

Language: Английский

Citations

0