Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(22), P. 16515 - 16515
Published: Nov. 20, 2023
The crosstalk among the complement system, immune cells, and mediators of inflammation provides an efficient mechanism to protect organism against infections support repair damaged tissues. Alterations in this complex machinery play a role pathogenesis different diseases. Core proteins C3 C5, their activation fragments, receptors, regulators have been shown be active intracellularly as complosome. kidney is particularly vulnerable complement-induced damage, emerging findings revealed system dysregulation wide range disorders, including glomerulopathies ischemia-reperfusion injury during transplantation. Different studies that important component tumorigenesis its elements proved present TME various human malignancies. renal cell carcinoma (RCC) has recently explored. Clear papillary RCC upregulate most genes relative normal tissue. aim narrative review provide novel insights into disorders.
Language: Английский
Citations
53
Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(11), P. 743 - 761
Published: April 10, 2024
Language: Английский
Citations
14
Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15
Published: July 3, 2024
Neurodegenerative and neuroinflammatory diseases, including Alzheimer’s disease, Parkinson’s multiple sclerosis, affect millions of people globally. As aging is a major risk factor for neurodegenerative the continuous increase in elderly population across Western societies also associated with rising prevalence these debilitating conditions. The complement system, crucial component innate immune response, has gained increasing attention its multifaceted involvement normal development central nervous system (CNS) brain but as pathogenic driver several disease states. Although generally understood liver-derived blood or interstitial fluid operative protecting against bloodborne pathogens threats, recent research, particularly on role healthy diseased CNS, demonstrated importance locally produced activated components. Here, we provide succinct overview over known beneficial pathological roles CNS focus local sources complement, discussion potential recently discovered intracellularly active biology infection-triggered neurodegeneration.
Language: Английский
Citations
9
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: April 7, 2025
The immune system serves as a critical line of defence against pathogenic microorganisms. To investigate the impact markers, measured within first 48 h intensive care unit (ICU) admission, on incidence healthcare-associated infections (HAIs) in ICU patients. This case-control study included 364 patients admitted from 1 January 2020 to 30 November 2023, receiving marker testing admission. Cox proportional hazard models and propensity score matching evaluated markers' association with HAIs risk. Log-rank tests compared time-to-event by C3 levels. All data processing analysis were performed using R version 4.2.0 (R Foundation for Statistical Computing, Vienna, Austria) Python 3.11 (Python Software Foundation, Wilmington, DE). In total, 258 without (mean [SD] age, 67.24 [17.79] years) 106 73.80 [14.93] final analysis. group had older longer hospital stay, lower Sequential Organ Failure Assessment (SOFA) scores, higher rate comorbid than non-HAIs group. Also, proportion basophils, lymphocytes, monocytes T suppressor cells (CD3 + CD8+), while neutrophils B (CD19+) was lower. After regression adjustment, we found that complement levels (HR: 0.40; 95%CI, 0.16-0.98; p = .044) influenced HAIs. Patients then divided into high low groups based cut-off value 0.455 C3. A plot showed median time occurrence nine days six (p .048). Elevated may associat reduced
Language: Английский
Citations
0
Leukemia, Journal Year: 2025, Volume and Issue: unknown
Published: April 23, 2025
Abstract Hematopoietic cells and lymphocytes arise from a common stem cell for both lineages. This explains why similar signaling networks regulate the development biological functions of these cells. One crucial regulatory mechanism involves interactions with soluble mediators innate immunity, including activated elements complement cascade (ComC). For many years, ComC proteins were thought to be synthesized only in liver released into blood by one three proteolytic cascades. The effects components on hematopoietic progenitor (HSPCs) mature have been well demonstrated past. However, recent data indicate that are also expressed several types, immune intracellular network has named “complosome.” Recent evidence our group shows complosome is HSPCs plays an important yet underappreciated role expansion, trafficking, metabolism We propose complosome, like its lymphocytes, necessary optimal function mitochondria cells, HSPCs. opens new area investigation potential pharmacological intervention normal malignant hematopoiesis.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 30, 2025
The Complement System (CS) comprises three catalytic pathways that can be activated by specific immune triggers. However, within the tumor microenvironment (TME), CS intracellular components, recently named as complosome, play roles extend beyond activation and regulation of its pathways. interaction between TME elements cells alters local response, leading to inflammation, cell proliferation, invasion. Our focus is on understanding significance complosome non-canonical in cancer. In this scoping review, we analyzed 45 articles discussed various components carcinogenesis. Many including C1q, C3a-C3aR, C5a-C5aR, factor H, properdin, some them at level, may a dual role progression, demonstrating either anti-tumor or pro-tumor activity independent complement pathway activation. function each component influence both type stage cells. There notable lack studies lectin development, knowledge gap must addressed fully understand Nevertheless, are crucial steps development.
Language: Английский
Citations
0
Clinical Kidney Journal, Journal Year: 2025, Volume and Issue: 18(5)
Published: May 1, 2025
ABSTRACT Systemic complement is a major contributor to the onset and progression of kidney graft injury. However, itself an important site production. Renal-derived plays key role in dysfunction, unlike some other solid organ transplants. Complement factors are generated by multiple renal cell types under both physiological pathological conditions. Renal production mediates ischemia/reperfusion injury acute cellular humoral rejection but protective effects cascade have been reported as well. More recently, intracellular activation (complosome) has also shown be regulator metabolic functions cells immune infiltrates, adding complexity field. Herein, we review current knowledge on renal-derived pathophysiology damage landscape targeted therapeutics transplantation.
Language: Английский
Citations
0
Scandinavian Journal of Immunology, Journal Year: 2023, Volume and Issue: 98(5)
Published: Sept. 11, 2023
Abstract Ulcerative colitis (UC) is an inflammatory bowel disorder (IBD) characterized by relapsing chronic inflammation of the colon that causes continuous mucosal inflammation. The global incidence UC steadily increasing. Immune mechanisms are involved in pathogenesis UC, which complement shown to play a critical role inducing local responses promote tissue damage. However, function various components development complex and even paradoxical. Some (e.g. C1q, CD46, CD55, CD59, C6) safeguard intestinal barrier reduce inflammation, while others C3, C5, C5a) can exacerbate damage accelerate UC. system was originally thought primarily extracellular mode; however, recent evidence indicates it also act intracellularly as complosome. current study provides overview studies on its While there few describe how intracellular contributes we discuss potential future directions based related publications. We highlight novel methods target for IBD treatment.
Language: Английский
Citations
5
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3374 - 3374
Published: March 16, 2024
Multiple sclerosis (MS) is a complex inflammatory disease affecting the central nervous system. Most commonly, it begins with recurrent symptoms followed by partial or complete recovery, known as relapsing–remitting MS (RRMS). Over time, many RRMS patients progress to secondary progressive (SPMS), marked gradual symptom deterioration. The factors triggering this transition remain unknown, lacking predictive biomarkers. This study aims identify blood biomarkers specific SPMS. We analyzed six datasets of SPMS and patients’ brain tissues, compared differential expressed genes (DEGs) obtained highlight DEGs reflecting alterations occurring in both tissues potential biological processes involved. observed total 38 up-regulated their interaction network was evaluated through analysis. Among aforementioned DEGs, 21 may be directly involved transition. Further, we highlighted three processes, including calcineurin–NFAT pathway, related investigated serve promising means monitor from SPMS, which still elusive. Given that they can also sourced samples, approach could offer relatively rapid convenient method for monitoring facilitating expedited assessments.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Citations
0