Effect of Diethylstilbestrol on Implantation and Decidualization in Mice DOI Open Access

Feng Ran,

Si‐Ting Chen,

Mengyuan Li

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4122 - 4122

Published: April 26, 2025

Diethylstilbestrol (DES) is a synthetic non-steroidal estrogen, which was widely used to prevent preterm birth and abortion from the 1940s 1970s. DES can increase incidence of infertility, abnormal reproductive tract, autoimmune diseases. However, mechanism underlying on early pregnancy in mice unclear. This study evaluated effects mice, especially uterine receptivity decidualization. Newborn female were subcutaneously injected with 0.1 mg/kg DES, 1 or sesame oil as controls for 5 consecutive days. At 6 weeks old, these mated 8-12-week-old fertile males obtain pregnancy. The uteri collected days 4, 5, 8 further analysis. On pregnancy, number implantation sites group similar control group, while almost no are detected group. day 4 there significant difference receptive molecules between levels abnormal. In addition, μM significantly inhibits mouse vitro excessive activation pyroptosis may lead failure. pyroptosis-related up-regulated, suggesting that contribute failure by over-activating pyroptosis.

Language: Английский

Pro-Inflammatory and Anti-Inflammatory Interleukins in Infectious Diseases: A Comprehensive Review DOI Creative Commons

Arwa A. Al-Qahtani,

Fatimah S. Alhamlan, Ahmed A. Al‐Qahtani

et al.

Tropical Medicine and Infectious Disease, Journal Year: 2024, Volume and Issue: 9(1), P. 13 - 13

Published: Jan. 4, 2024

Interleukins (ILs) are signaling molecules that crucial in regulating immune responses during infectious diseases. Pro-inflammatory ILs contribute to the activation and recruitment of cells, whereas anti-inflammatory help suppress excessive inflammation promote tissue repair. Here, we provide a comprehensive overview role pro-inflammatory diseases, with focus on mechanisms underlying their effects, diagnostic therapeutic potential, emerging trends IL-based therapies.

Language: Английский

Citations

94
New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation DOI Creative Commons
Triveni Kodi, Runali Sankhe, Adarsh Gopinathan

et al.

Journal of Neuroimmune Pharmacology, Journal Year: 2024, Volume and Issue: 19(1)

Published: Feb. 29, 2024

Abstract Inflammasomes are important modulators of inflammation. Dysregulation inflammasomes can enhance vulnerability to conditions such as neurodegenerative diseases, autoinflammatory and metabolic disorders. Among various inflammasomes, Nucleotide-binding oligomerization domain leucine-rich repeat pyrin domain-containing protein 3 (NLRP3) is the best-characterized inflammasome related inflammatory diseases. NLRP3 an intracellular sensor that recognizes pathogen-associated molecular patterns damage-associated resulting in assembly activation inflammasome. The includes NLRP3, adaptor apoptosis-associated speck-like (ASC), effector cysteine protease procaspase-1 plays imperative role caspase-1 stimulation which further initiates a secondary response. Regulation ameliorates NLRP3-mediated Much effort has been invested studying activation, exploration specific inhibitors epigenetic mechanisms controlling This review gives overview established assembly, its brief mechanistic activations well current update on non-specific could be used We also focused recently discovered mediated by DNA methylation, histone alterations, microRNAs regulating expression inflammasome, resulted novel method gaining insight into modulate activity introducing potential therapeutic strategies for CNS Graphical "Image missing"

Language: Английский

Citations

31
The critical role of NLRP3 in drug resistance of cancers: Focus on the molecular mechanisms and possible therapeutics DOI
Beena Briget Kuriakose, Ahmed Hussein Zwamel, Ayad Abdulrazzaq Mutar

et al.

Seminars in Oncology, Journal Year: 2025, Volume and Issue: 52(1), P. 27 - 40

Published: Feb. 1, 2025

Language: Английский

Citations

1
Mechanisms and Therapeutic Strategies for NLRP3 Degradation via Post-Translational Modifications in Ubiquitin-proteasome and Autophagy Lysosomal Pathway DOI

Kaiyue Su,

Minghai Tang, Jie Wu

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 289, P. 117476 - 117476

Published: March 4, 2025

Language: Английский

Citations

1
Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity DOI
Ziyu Guo,

Yihuang Liu,

Danyao Chen

et al.

Journal of Translational Internal Medicine, Journal Year: 2025, Volume and Issue: 13(1), P. 10 - 32

Published: Feb. 1, 2025

In the evolving landscape of cancer treatment, strategic manipulation regulated cell death (RCD) pathways has emerged as a crucial component effective anti-tumor immunity. Evidence suggests that tumor cells undergoing RCD can modify immunogenicity microenvironment (TME), potentially enhancing its ability to suppress progression and metastasis. this review, we first explore mechanisms apoptosis, necroptosis, pyroptosis, ferroptosis, cuproptosis, along with crosstalk between these modalities. We then discuss how processes activate antigen-presenting cells, facilitate cross-priming CD8+ T trigger immune responses, highlighting complex effects novel forms on TME biology. Furthermore, summarize potential drugs nanoparticles induce or inhibit emerging their therapeutic roles in treatment. Finally, put forward existing challenges future prospects for targeting anti-cancer Overall, review enhances our understanding molecular biological impacts RCD-based therapies, providing new perspectives strategies

Language: Английский

Citations

1
Review on the role of nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome pathway in diabetes: mechanistic insights and therapeutic implications DOI
Abhishek Satheesan, Janardanan Kumar,

K.V. Leela

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 2753 - 2779

Published: Aug. 19, 2024

Language: Английский

Citations

6
Exploring ncRNA-mediated pathways in sepsis-induced pyroptosis DOI
Asif Ahmad Bhat, Yassine Riadi, Muhammad Afzal

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 256, P. 155224 - 155224

Published: Feb. 23, 2024

Language: Английский

Citations

6
Endoplasmic Reticulum Stress Mediated NLRP3 Inflammasome Activation and Pyroptosis in THP-1 Macrophages Infected with Bacillus Calmette-Guérin DOI Open Access

Xueyi Nie,

Boli Ma,

Lei Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(14), P. 11692 - 11692

Published: July 20, 2023

Tuberculosis (TB) is a zoonotic infectious disease caused by Mycobacterium tuberculosis (Mtb). Mtb typical intracellular parasite, and macrophages are its main host cells. NLRP3 inflammasome-mediated pyroptosis form of programmed cell death implicated in the clearance pathogenic infections. The bidirectional regulatory effect endoplasmic reticulum stress (ERS) plays crucial role determining survival death. Whether ERS involved macrophage with infection remains unclear. This article aims to explore regulation inflammasome THP-1 infected bovis Bacillus Calmette-Guérin (BCG). results showed that BCG induced ERS, activation pyroptosis, which was inhibited inhibitor TUDCA. MCC950 infection. Compared specific Caspase-1 VX-765, pan-Caspase Z-VAD-FMK more significant inhibitory on infection-induced macrophages. Taken together, this study demonstrates mediated after macrophages, induces through canonical noncanonical pathways.

Language: Английский

Citations

13
Harnessing Pyroptosis for Lung Cancer Therapy: The Impact of NLRP3 Inflammasome Activation DOI
Rajiv Dahiya, Vijaykumar Sutariya, Sheeba Varghese Gupta

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 260, P. 155444 - 155444

Published: Aug. 1, 2024

Language: Английский

Citations

4
Microglia-induced neuroinflammation in hippocampal neurogenesis following traumatic brain injury DOI Creative Commons
Seyedeh Parisa Navabi, Firuzeh Badreh, Maryam Khombi Shooshtari

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e35869 - e35869

Published: Aug. 1, 2024

Traumatic brain injury (TBI) is one of the most causes death and disability among people, leading to a wide range neurological deficits. The important process neurogenesis in hippocampus, which includes production, maturation integration new neurons, affected by TBI due microglia activation inflammatory response. During development, are involved forming or removing synapses, regulating number repairing damage. However, response injury, activated release variety pro-inflammatory cytokines, chemokines other neurotoxic mediators that exacerbate post-TBI injury.These microglia-related changes can negatively affect hippocampal disrupt learning memory processes. To date, intracellular signaling pathways trigger following TBI, as well effects on neurogenesis, poorly understood. In this review article, we discuss microglia-induced neuroinflammation activation.

Language: Английский

Citations

4