Preparation of Environmentally Responsive PDA&DOX@LAC Live Drug Carrier for synergistic tumor therapy DOI Creative Commons
Lu Liu, Xuefen Zhao

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The development of intelligent, environmentally responsive, and biocompatible photothermal system holds significant importance for the combined therapy tumors. In this study, inspired by lactobacillus, we prepared a biomimetic nanoplatform, PDA&DOX@LAC, tumor photothermal-chemotherapy integrating chemotherapeutic drug doxorubicin (DOX) with dopamine through oxidative polymerization to form polydopamine on surface LAC. PDA&DOX@LAC nanoplatform not only achieves precise controlled release DOX based slightly acidic microenvironment tissues, but also exhibits enzyme-like properties alleviate hypoxia. Under near-infrared light irradiation, it effectively induces ablation cells, enhances cellular uptake increasing temperature, thus efficiently inhibits cell growth. Moreover, in vivo experiments further confirmed that cells apoptosis, releases tumor-associated antigens, is engulfed dendritic activating cytotoxic T lymphocytes, thereby suppressing growth prolonging survival period 4T1 tumor-bearing mice. Therefore, immense potential in targeting therapy, providing valuable insights theoretical foundations novel treatment strategies endogenous substances within body.

Language: Английский

Preparation of environmentally responsive PDA&DOX@LAC live drug carrier for synergistic tumor therapy DOI Creative Commons
Lu Liu, Xuefen Zhao

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 10, 2024

Abstract The development of intelligent, environmentally responsive and biocompatible photothermal system holds significant importance for the combined therapy tumors. In this study, inspired by Lactobacillus (LAC), we prepared a biomimetic nanoplatform PDA&DOX@LAC tumor photothermal-chemotherapy integrating chemotherapeutic drug doxorubicin (DOX) with dopamine through oxidative polymerization to form polydopamine (PDA) on surface LAC. not only achieves precise controlled release DOX based slightly acidic microenvironment tissues, but also exhibits enzyme-like properties alleviate hypoxia. Under near-infrared light irradiation, it effectively induces ablation cells, enhances cellular uptake increasing temperature, thus efficiently inhibits cell growth. Moreover, is further confirmed in vivo experiments that cells apoptosis, releases tumor-associated antigens, which engulfed dendritic activate cytotoxic T lymphocytes, thereby suppressing growth prolonging survival period 4T1 tumor-bearing mice. Therefore, immense potential targeting as well provides valuable insights theoretical foundations novel treatment strategies endogenous substances within body.

Language: Английский

Citations

2
Metabolic regulating enhanced immunological activating nanocomposites for tumor microenvironment normalization and immunotherapy DOI
Chen Wang,

Qiliner Feng,

Hongli Lu

et al.

Materials Today Nano, Journal Year: 2024, Volume and Issue: 27, P. 100509 - 100509

Published: Aug. 1, 2024

Language: Английский

Citations

1
Preparation of Environmentally Responsive PDA&DOX@LAC Live Drug Carrier for synergistic tumor therapy DOI Creative Commons
Lu Liu, Xuefen Zhao

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 7, 2024

Abstract The development of intelligent, environmentally responsive, and biocompatible photothermal system holds significant importance for the combined therapy tumors. In this study, inspired by lactobacillus, we prepared a biomimetic nanoplatform, PDA&DOX@LAC, tumor photothermal-chemotherapy integrating chemotherapeutic drug doxorubicin (DOX) with dopamine through oxidative polymerization to form polydopamine on surface LAC. PDA&DOX@LAC nanoplatform not only achieves precise controlled release DOX based slightly acidic microenvironment tissues, but also exhibits enzyme-like properties alleviate hypoxia. Under near-infrared light irradiation, it effectively induces ablation cells, enhances cellular uptake increasing temperature, thus efficiently inhibits cell growth. Moreover, in vivo experiments further confirmed that cells apoptosis, releases tumor-associated antigens, is engulfed dendritic activating cytotoxic T lymphocytes, thereby suppressing growth prolonging survival period 4T1 tumor-bearing mice. Therefore, immense potential in targeting therapy, providing valuable insights theoretical foundations novel treatment strategies endogenous substances within body.

Language: Английский

Citations

0