From silent partners to potential therapeutic targets: macrophages in colorectal cancer DOI Creative Commons
Hayat Khizar, Kamran Ali, Jianwei Wang

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(4)

Published: Feb. 25, 2025

Cancer cells grow and survive in the tumor microenvironment, which is a complicated process. As key part of how colorectal cancer (CRC) progresses, tumor-associated macrophages (TAMs) exhibit double role. Through angiogenesis, this TAM can promote growth cancers. Although being able to modify adjust immune great advantage, these also anti-cancer properties including direct killing cells, presenting antigens, aiding T cell-mediated responses. The delicate regulatory mechanisms between system tumors are composed complex network pathways regulated by several factors hypoxia, metabolic reprogramming, cytokine/chemokine signaling, cell interactions. Decoding figuring out systems become significant building targeted treatment programs. Targeting TAMs CRC involves disrupting chemokine signaling or adhesion molecules, reprogramming them an anti-tumor phenotype using TLR agonists, CD40 modulation, selectively removing subsets that growth. Multi-drug resistance, absence accurate biomarker, drug non-specificity major problems. Combining macrophage-targeted therapies with chemotherapy immunotherapy may revolutionize treatment. Macrophage studies will advance new technology multi-omics methodologies help us understand build specific efficient treatments.

Language: Английский

The Interplay Between Autophagy and Apoptosis in the Mechanisms of Action of Stilbenes in Cancer Cells DOI Creative Commons
Kamila Siedlecka-Kroplewska, Zbigniew Kmieć, Michał A. Żmijewski

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 339 - 339

Published: March 13, 2025

Plant-based stilbenes are low-molecular-weight polyphenolic compounds that exhibit anti-oxidant, anti-microbial, anti-fungal, anti-inflammatory, anti-diabetic, cardioprotective, neuroprotective, and anti-cancer activities. They phytoalexins produced in diverse plant species response to stress, such as fungal bacterial infections or excessive UV irradiation. Plant-derived dietary products containing common components of the human diet. Stilbenes appear be promising chemopreventive chemotherapeutic agents. Accumulating evidence indicates able trigger both apoptotic autophagic molecular pathways many cancer cell lines. Of note, crosstalk between autophagy apoptosis under cellular stress conditions determines fate. The relationship is complex depends on context, e.g., type level. Apoptosis a regulated death, whereas may act pro-survival pro-death mechanism depending context. interplay have an important impact chemotherapy efficiency. This review focuses vitro effects different lines concerning apoptosis.

Language: Английский

Citations

0
Translocator protein (TSPO) in glioma: implications for diagnosis, disease progression monitoring, and targeted therapies DOI Creative Commons

Julius Mulumba,

Bo Luo, Jiang Wu

et al.

Exploration of neuroscience, Journal Year: 2025, Volume and Issue: 4

Published: April 1, 2025

Glioma is a highly aggressive brain cancer associated with significant mortality. Despite advances in diagnostic and therapeutic strategies, the prognosis for glioma patients remains poor due to limited accuracy monitoring capabilities. Translocator protein (TSPO) mitochondrial implicated various cancers, including glioma, where it plays role cell survival, proliferation, chemo-resistance. This review article aimed comprehensively analyze of TSPO particularly its potential applications enhancing methods strategies. Molecular imaging techniques have emerged as promising tools non-invasive diagnosis, disease progression monitoring, treatment selection gliomas. A comprehensive literature was conducted explore TSPO’s expression patterns, biological functions, molecular imaging. Studies utilizing positron emission tomography (PET), single photon computed (SPECT), magnetic resonance (MRI), other modalities were included. overexpressed cells, high-grade tumors, correlating tumor aggressiveness patient prognosis. TSPO-targeted agents demonstrate high specificity sensitivity detection, positioning marker accurate diagnosis monitoring. Future studies should focus on optimizing protocols, validating their clinical utility, exploring combined improve precision.

Language: Английский

Citations

0
Updated review on analysis of long non-coding RNAs as emerging diagnostic and therapeutic targets in prostate cancers DOI
Zongpan Ke, Xuechun Hu,

Yixun Liu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 196, P. 104275 - 104275

Published: Feb. 1, 2024

Language: Английский

Citations

3
Targeting tumor-associated macrophages with nanocarrier-based treatment for breast cancer: A step toward developing innovative anti-cancer therapeutics DOI Creative Commons
Ghazala Muteeb, Doaa S. R. Khafaga,

Manar T El-Morsy

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37217 - e37217

Published: Aug. 30, 2024

Language: Английский

Citations

3
From silent partners to potential therapeutic targets: macrophages in colorectal cancer DOI Creative Commons
Hayat Khizar, Kamran Ali, Jianwei Wang

et al.

Cancer Immunology Immunotherapy, Journal Year: 2025, Volume and Issue: 74(4)

Published: Feb. 25, 2025

Cancer cells grow and survive in the tumor microenvironment, which is a complicated process. As key part of how colorectal cancer (CRC) progresses, tumor-associated macrophages (TAMs) exhibit double role. Through angiogenesis, this TAM can promote growth cancers. Although being able to modify adjust immune great advantage, these also anti-cancer properties including direct killing cells, presenting antigens, aiding T cell-mediated responses. The delicate regulatory mechanisms between system tumors are composed complex network pathways regulated by several factors hypoxia, metabolic reprogramming, cytokine/chemokine signaling, cell interactions. Decoding figuring out systems become significant building targeted treatment programs. Targeting TAMs CRC involves disrupting chemokine signaling or adhesion molecules, reprogramming them an anti-tumor phenotype using TLR agonists, CD40 modulation, selectively removing subsets that growth. Multi-drug resistance, absence accurate biomarker, drug non-specificity major problems. Combining macrophage-targeted therapies with chemotherapy immunotherapy may revolutionize treatment. Macrophage studies will advance new technology multi-omics methodologies help us understand build specific efficient treatments.

Language: Английский

Citations

0