Progress towards the clinical use of antimicrobial peptides: challenges and opportunities DOI
Paula Espinal, Ester Fusté, Josep M. Sierra

et al.

Expert Opinion on Biological Therapy, Journal Year: 2023, Volume and Issue: 23(7), P. 641 - 650

Published: June 27, 2023

Introduction To overcome the challenge of multidrug resistance, natural and synthetic peptides are candidates to become basis innovative therapeutics, featuring diverse mechanisms action. Traditionally, time elapsed from medical discoveries their application is long. The urgency derived emergence antibiotic resistance recommends an acceleration research put new weapons in hands clinicians.Areas covered This narrative review introduces ideas suggestions strategies that may be used as a upon which recommend reduced development times facilitate arrival molecules fight against microbes.Expert opinion Although studies on antimicrobial treatments being conducted, sooner rather than later, more clinical trials, preclinical translational needed promote for resistant infections. situation worrying, no less generated by pandemics such ones we have just experienced conflicts world wars. point view human perception, antibiotics not seem serious these other situations, it possibly hidden pandemic most jeopardizes future medicine.

Language: Английский

Recent advances on vaccines against malaria: A review DOI Creative Commons
Shiza Malik, Yasir Waheed

Asian Pacific Journal of Tropical Medicine, Journal Year: 2024, Volume and Issue: 17(4), P. 143 - 159

Published: April 1, 2024

This review aims to summarize the currently viable vaccine strategies including approved vaccines and those in trials for next-generation malaria vaccines. Data on development was collected through a comprehensive review. The literature search performed using databases Google Scholar, PubMed, NIH, Web of Science. Various novel approaches vaccination are being developed, based radiation-attenuated strategies, monoclonal antibodies, targeted immunogenic peptides, RNA DNA vaccines, nanoparticle-based protein-based protocols, whole organism-based strategies. Trials RTS, S have entered phase III testing, blood-stage interrupt malarial transmission advanced higher stages trials. Mathematical modeling, combined drug mass administration, polyvalent formulations, campaigns is playing an important role prevention. Furthermore, assessing coverage, accessibility, acceptability, deployment, compilation, adherence specific endemic regions essential drives against malaria.

Language: Английский

Citations

2
Advancing Vaccinology Capacity: Education and Efforts in Vaccine Development and Manufacturing across Africa DOI Creative Commons

Jean Paul Sinumvayo,

Pierre Celestin Munezero,

Adegboyega Taofeek Tope

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(7), P. 741 - 741

Published: July 3, 2024

Africa, home to the world’s second-largest population of approximately 1.3 billion, grapples with significant challenges in meeting its medical needs, particularly accessing quality healthcare services and products. The continent faces a continuous onslaught emerging infectious diseases, exacerbating strain on already fragile public health infrastructure. COVID-19 crisis highlighted urgency build local vaccine production capacity strengthen infrastructure general. risks associated heavy reliance imported vaccines were exposed during pandemic, necessitating need nurture manufacturing therapeutic biologics. Various initiatives addressing training, manufacturing, regulatory affairs are underway, these require increasing dedicated purposeful financial investment. Building requires substantial investment training This manuscript examines current state education vaccinology related sciences Africa. It also provides an overview continent’s efforts address educational needs development manufacturing. Additionally, it evaluates aimed at strengthening literacy, highlighting successful approaches ongoing challenges. By assessing progress made identifying remaining obstacles, this review offers insights into how Africa can enhance respond vaccine-preventable disease

Language: Английский

Citations

2
Long-Lasting Enhanced Cytokine Responses Following SARS-CoV-2 BNT162b2 mRNA Vaccination DOI Creative Commons
Georgiana Cabău, Medeea Badii, Andreea-Manuela Mirea

et al.

Vaccines, Journal Year: 2024, Volume and Issue: 12(7), P. 736 - 736

Published: July 3, 2024

The mRNA vaccine against COVID-19 protects severe disease by the induction of robust humoral and cellular responses. Recent studies have shown capacity some vaccines to induce enduring non-specific innate immune responses trained immunity, augmenting protection unrelated pathogens. This study aimed assess whether BNT162b2 can lasting in myeloid cells following a three-dose vaccination scheme. In sample size consisting 20 healthy individuals from Romania, we assessed inflammatory proteins using Olink® Target 96 Inflammation panel, as well ex vivo cytokine stimulations with PRR ligands. We vaccine-induced systemic inflammation functional adaptations cells. Our results revealed stimulus- cytokine-dependent memory phenotype that became apparent after booster dose was maintained eight months later absence inflammation.

Language: Английский

Citations

2
A lipid nanoparticle-mRNA vaccine provides potent immunogenicity and protection againstMycobacterium tuberculosis DOI Creative Commons

Hannah Lukeman,

Hareth Al-Wassiti, Stewart A. Fabb

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 31, 2024

Abstract Mycobacterium tuberculosis remains the largest infectious cause of mortality worldwide, even with over a century widespread administration only licensed (TB) vaccine, Bacillus Calmette-Guérin (BCG). mRNA technology an underexplored approach for combating chronic bacterial infections such as TB. We have developed lipid nanoparticle (LNP)-mRNA vaccine encoding fusion protein two immunogenic TB antigens, termed CV2 . In C57BL/6 mice intramuscularly vaccinated , high frequencies polyfunctional, antigen-specific Th1 CD4 + T cells were observed in blood and lungs, which was associated rapid recruitment both innate adaptive immune to lymph nodes draining site immunisation. vaccination provided significant pulmonary protection M. -infected mice, reducing load inflammatory infiltration lungs. As BCG is widely administered infants endemic countries, new vaccines should be able boost effects BCG. Importantly, enhanced responses long-term when used BCG-primed mice. These findings, provide first report highly protective LNP-mRNA TB, highlight potential platform control support further research facilitate translation humans.

Language: Английский

Citations

2
Progress towards the clinical use of antimicrobial peptides: challenges and opportunities DOI
Paula Espinal, Ester Fusté, Josep M. Sierra

et al.

Expert Opinion on Biological Therapy, Journal Year: 2023, Volume and Issue: 23(7), P. 641 - 650

Published: June 27, 2023

Introduction To overcome the challenge of multidrug resistance, natural and synthetic peptides are candidates to become basis innovative therapeutics, featuring diverse mechanisms action. Traditionally, time elapsed from medical discoveries their application is long. The urgency derived emergence antibiotic resistance recommends an acceleration research put new weapons in hands clinicians.Areas covered This narrative review introduces ideas suggestions strategies that may be used as a upon which recommend reduced development times facilitate arrival molecules fight against microbes.Expert opinion Although studies on antimicrobial treatments being conducted, sooner rather than later, more clinical trials, preclinical translational needed promote for resistant infections. situation worrying, no less generated by pandemics such ones we have just experienced conflicts world wars. point view human perception, antibiotics not seem serious these other situations, it possibly hidden pandemic most jeopardizes future medicine.

Language: Английский

Citations

4