Post-acute sequelae of SARS-CoV-2 infection (Long COVID) in older adults

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: June 14, 2024

Language: Английский

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A systematic analysis of the literature on the post-COVID-19 condition in Latin America focusing on epidemiology, clinical characteristics, and risk of bias

Medwave, Journal Year: 2025, Volume and Issue: 25(01), P. e3014 - e3014

Published: Jan. 16, 2025

This analysis article aimed to identify and analyze all articles published on the post-COVID-19 condition in Latin America Caribbean, focusing epidemiology, clinical characteristics, risk of bias. We did a systematic survey literature with broad inclusion criteria. The only exclusion criteria were referring post-acute COVID-19 sequelae after an intensive care unit stay, which we distinguish from condition. searched MEDLINE/PubMed, LILACS, SciELO, Scopus, Web Science, Epistemonikos. included 55 records, 48 original (44 observational research, 29 had comparison group; four reviews). Various definitions for long COVID reported, or none, few used World Health Organization None studies reported prevalence rates region. extracted signs symptoms our Using Johanna Briggs Institute critical appraisal tools analytic found that most prone limitations biases. conclude more research should be done using rigorous study designs inform public health strategies.

Language: Английский

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Prevalence of depression, anxiety, stress, and suicide tendency among individual with long-COVID and determinants: A systematic review and meta-analysis

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0312351 - e0312351

Published: Jan. 28, 2025

Background While mental health alterations during active COVID-19 infection have been documented, the prevalence of long-term consequences remains unclear. This study aimed to determine symptoms—depression, anxiety, stress, and suicidal tendencies—and identify their trends associated risk factors in individuals with long-COVID. Methods We conducted a systematic literature search databases including PubMed, EMBASE, Scopus, CINAHL, Cochrane Library, Web Science, PsycINFO up August 2024, targeting observational studies published English. Study quality was assessed using structured standard tools. The primary outcome pooled depression, tendencies Secondary outcomes included these problems over time identification determinants. Results A total 94 eligible were analysis. estimates, regardless follow times duration, as follows: 25% (95%CI:22–28%; PI:1–59%); anxiety (adjusted via trim fill method), 23%(95%CI:21–25%;PI:2–35%); composite depression and/or (95%CI:23–27%;PI:2–51%); 26%(95%CI:13–39%;PI:1–69%); suicidality, 19%(95%CI:15–22%;PI:13–25%). results meta-regression analyses revealed statistically significant trend showing gradual decrease (RD = -0.004,P 0.022). Meta-regression indicated that being female younger age significantly higher symptoms. design setting did not contribute heterogeneity. Conclusion One-fourth individual long-COVID experience symptoms, which remain prevalent even two years post-infection despite slight decreasing trend. Factors such gender linked rates depression. These findings indicate need for ongoing screening early interventions mitigate psychological distress patients.

Language: Английский

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Cognition and Long COVID: A PRISMA Systematic Review of Longitudinal Studies

Revista de Neurología, Journal Year: 2025, Volume and Issue: 79(12)

Published: Jan. 24, 2025

Introduction: Long COVID is defined by National Institute for Health and Care Excellence (NICE) as the set of signs symptoms that develop during or after a SARS-CoV-2 infection continue more than twelve weeks without any alternative diagnosis. One most frequent persistent reported patients verified in neuroimaging studies cognitive dysfunction, due to generalized hypoconnectivity diffuse axonal lesion white matter. Therefore, objectives present review are determine how long functions remain affected explore which beyond three months follow-up up 65 years age previous neuropsychological psychiatric complications. Methods: A systematic was performed using PRISMA criteria 11 articles were included through comprehensive search five different databases: PubMed, Medline, Scopus, WOS ProQuest. The risk bias assessed Newcastle-Ottawa scale. Results: Cognitive problems persist over time improve slowly, although seem agree areas improved significantly one year. remained impaired longest processing speed attention. Conclusions: These alterations cause reduction quality life work capacity manifest need intervention.

Language: Английский

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Cognitive Impairments in Two Samples of Individuals with ME/CFS and Long COVID: A Comparative Analysis

Journal of Clinical Psychology in Medical Settings, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Language: Английский

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Post-COVID-19 condition: systemic inflammation and low functional exercise capacity

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: March 14, 2024

Introduction Post-COVID-19 condition (PCC) is characterised by a plethora of symptoms, with fatigue appearing as the most frequently reported. The alterations that drive both persistent and post-acute disease newly acquired symptoms are not yet fully described. Given lack robust knowledge regarding mechanisms PCC we have examined impact inflammation in PCC, evaluating serum cytokine profile its potential involvement inducing different Methods In this cross-sectional study, recruited 227 participants who were hospitalised acute COVID-19 2020 came back for follow-up assessment 6–12 months after hospital discharge. enrolled two symptomatic groups: Self-Reported Symptoms group (SR, n = 96), did present major organ lesions, reported several debilitating such fatigue, muscle weakness, loss sense smell taste; decreased Pulmonary Function (SRPF, 54), composed individuals same described SR, plus diagnosed pulmonary lesions. A Control ( 77), minor complaints following COVID-19, was also included study. Serum levels, symptom questionnaires, physical performance tests general clinical data obtained assessment. Results SRPF presented lower IL-4 concentration compared q 0.0018) SR 0.030), IFN-α2 content 0.007). addition, higher MIP-1β 0.029). CCL11 0.012 0.001, respectively) MCP-1 levels 0.052 both) SRPF. G-CSF to 0.014). Female showed handgrip strength relation 0.0082). Male needed more time complete timed up-and-go test, men 0.0302 0.0078, respectively). Our results indicate profiles accompanied distinct inflammatory markers circulation. Of particular concern function findings, likely long-lasting consequences health quality life, found phenotypes.

Language: Английский

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CURRENT CONCEPTS IN LONG-COVID BRAIN FOG AND POSTURAL ORTHOSTATIC TACHYCARDIA SYNDROME

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(5), P. 522 - 530

Published: Aug. 23, 2024

Language: Английский

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Long-term risk of reduced cognitive performance and associated factors in discharged older adults with coronavirus disease 2019: A longitudinal prospective study

Annals of Geriatric Medicine and Research, Journal Year: 2024, Volume and Issue: 28(1), P. 76 - 85

Published: Jan. 16, 2024

Increasing numbers of reports have suggested a deterioration in cognitive performance after recovery from coronavirus disease 2019 (COVID-19), however insufficient information is available regarding long-term brain health and risk factors related to reduced advanced age. We investigated the prevalence its associated among older adults COVID-19.

Language: Английский

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Data-driven, cross-disciplinary collaboration: lessons learned at the largest academic health center in Latin America during the COVID-19 pandemic

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 27, 2024

Introduction The COVID-19 pandemic has prompted global research efforts to reduce infection impact, highlighting the potential of cross-disciplinary collaboration enhance quality and efficiency. Methods At FMUSP-HC academic health system, we implemented innovative flow management routines for collecting, organizing analyzing demographic data, COVID-related data biological materials from over 4,500 patients with confirmed SARS-CoV-2 hospitalized 2020 2022. This strategy was mainly planned in three areas: a database hospitalizations; setting-up multidisciplinary taskforce conduct follow-up assessments after discharge; biobank. Additionally, curated collection created within institutional digital library papers map output. Results Over course experience, possible benefits challenges this type support approach were identified discussed, leading set recommended strategies institution. Demographic clinical hospitalizations compiled including adults minority children adolescents laboratory COVID-19, covering 2020–2022, approximately 350 fields per patient. To date, been used 16 published studies. assessed 700 6 11 months hospitalization through comprehensive, in-person evaluations; database, comprising around 2000 subject, 15 publications. Furthermore, thousands blood samples collected during acute phase remain stored future investigations. more than 3,700 aliquots have ongoing investigating various aspects COVID-19. Lastly, mapping overall output revealed that between 2022 our system produced 1,394 scientific articles on Discussion Research is crucial component an effective epidemic response, preparation process should include well-defined plan sharing resources. initiatives described present paper successful aim foster large-scale Although single model may not be appropriate all contexts, open make systems efficient generate best evidence.

Language: Английский

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Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

The emergence of SARS-CoV-2 has precipitated a global pandemic with substantial long-term health implications, including the condition known as post-acute sequelae infection (PASC), commonly referred to Long COVID. PASC is marked by persistent symptoms such fatigue, neurological issues, and autonomic dysfunction that persist for months beyond acute phase COVID-19. This review examines potential role herpesvirus reactivation, specifically Epstein-Barr virus (EBV) cytomegalovirus (CMV), in pathogenesis PASC. Elevated antibody titers specific T cell responses suggest recent reactivation some patients, although viremia not consistently detected. exhibits endothelial trophism, directly affecting vascular endothelium contributing microvascular pathologies. These pathologies are significant PASC, where may underlie various chronic symptoms. Similarly, herpesviruses like CMV also exhibit which exacerbate damage when reactivated. Evidence suggests EBV could indirectly contribute immune dysregulation, immunosenescence, autoimmune observed Additionally, play genesis through creating mitochondrial dysfunction, though direct confirmation remains elusive. reviewed evidence while their indirect effects, especially context involvement, warrant further investigation.

Language: Английский

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