Clinical usefulness of the serum levels of neuroinflammatory and lung fibrosis biomarkers in the assessment of cognitive dysfunction in post-COVID19 patients

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 28, 2024

Language: Английский

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Self-reported health, neuropsychological tests and biomarkers in fully recovered COVID-19 patients vs patients with post-COVID cognitive symptoms: a pilot study

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 29, 2024

Abstract Objective Substantial numbers of individuals who contract COVID-19 experience long-lasting cognitive symptoms such as brain fog. Yet research to date has not compared these patients with healthy controls a history laboratory-confirmed infection, making it difficult understand why certain COVID develop post-COVID while others do not. The objective this pilot study was compare two groups patients, and without symptoms, on measures psychological functioning, self-reported perceptions functional status quality life, biomarkers stress, inflammation, neuroplasticity. Methods Using case-control design, 17 participants were recruited from healthcare system in western Michigan, USA 2022 through 2024. All aged 25-65 had positive polymerase chain reaction (PCR) test confirming previous infection. Ten reported (long group) seven fully recovered no residual (controls). underwent an interview their self-rated health battery neurocognitive tests, blood draw for biomarker analysis. Results No group differences detected neuropsychological except letter fluency where the long scored significantly lower (p<.05). ratings than physical health, emotional well-being. Serum levels nerve growth factor (NGF), plasticity, group, which more likely have serum inflammatory marker (interleukin (IL)-10) values greater or equal median (p=0.015). Conclusion Biomarker analyses suggest possible prolonged processes patients. decreased neuroplastic functioning give credence patients’ reports changes function.

Language: Английский

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Cortical thickness alterations and systemic inflammation define long-COVID patients with cognitive impairment

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 23, 2023

Abstract As the heterogeneity of symptoms is increasingly recognized among long-COVID patients, it appears highly relevant to study potential pathophysiological differences along different subtypes. Preliminary evidence suggests distinct alterations in brain structure and systemic inflammatory patterns specific groups patients. To this end, we analyzed cortical thickness peripheral immune signature between clinical subgroups based on 3T-MRI scans markers n=120 participants comprising healthy never-infected controls, COVID-19 survivors, patients with without cognitive impairment according screening Montreal Cognitive Assessment. Whole-brain comparison 4 was conducted by surface-based morphometry. We identified areas showing a progressive increase across groups, starting from individuals who had never been infected COVID-19, followed deficits (MoCA ≥ 26), finally, exhibiting significant < 26). These findings highlight continuum associated more pronounced changes observed experiencing (p<0.05, FWE-corrected). Affected regions covered prefrontal temporal gyri, insula, posterior cingulate, parahippocampal gyrus, parietal areas. Additionally, discovered immunophenotype, elevated levels IL-10, IFNγ, sTREM2 especially group suffering impairment. demonstrate lingering immunological impaired survivors. This implies complex underlying pathomechanism emphasizes necessity investigate whole spectrum post-COVID biology determine targeted treatment strategies targeting sub-groups.

Language: Английский

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Clinical Rationale for Dietary Lutein Supplementation in Post COVID-19 and mRNA Vaccine Injury Syndromes

Published: Sept. 20, 2023

Lutein, a plant-derived xanthophyl-carotenoid, is an exceptional antioxidant and anti-inflammatory constituent found in food. Elevated concentrations of lutein human blood plasma, due to high dietary intake, are beneficial against eye disease improve cardiometabolic health. Lutein plays important protective role the development neurological disorders, including Alzheimer&rsquo;s (AD), multiple sclerosis (MS) Parkinson&rsquo;s (PD). It has also been shown be for liver, kidney respiratory acting as very strong antioxidant, can alleviate oxidative stress downgrade reactive oxygen species (ROS). Oxidative one key pathogenic mechanisms post-COVID mRNA vaccine injury syndromes. Recent silico studies suggest that other naturally derived antioxidants, by docking at site where SARS-CoV-2 spike protein (SP) binds angiotensin enzyme type 2 (ACE2) receptor, may neutralize SP-ACE2 interactions. added detoxification regimen aid clearing Spike relieving symptoms. In agreement with Hippocrates&rsquo; dictum &ldquo;Let food thy medicine,&rdquo; this review establishes valuable therapy treatment syndrome, syndromes, wide range chronic illnesses.

Language: Английский

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Disease severity is associated with depressive symptoms and suicidal thoughts in Brazilian patients with inflammatory bowel disease

General Hospital Psychiatry, Journal Year: 2023, Volume and Issue: 84, P. 273 - 275

Published: July 26, 2023

Language: Английский

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