ALifelikeguided journey through the pathophysiology of pulmonary hypertension - from measured metabolites to the mechanism of action of drugs DOI Open Access
Nathan Weinstein,

Jørn Carlsen,

Sebastian Schulz

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 22, 2023

A bstract Pulmonary hypertension (PH) is a pathological condition that affects approximately 1% of the population. The prognosis for many patients poor, even after treatment. Our knowledge about pathophysiological mechanisms cause or are involved in progression PH incomplete. Additionally, mechanism action drugs used to treat pulmonary hypertension, including sotatercept, requires elucidation. Using our graph-powered mining software Lifelike combination with very small patient metabolite data set, we demonstrate how derive detailed mechanistic hypotheses on pathophysiology and clinical drugs. In patients, concentration hypoxanthine, 12(S)-HETE, glutamic acid, sphingosine 1 phosphate significantly higher, while L-arginine L-histidine lower than healthy controls. graph-based analysis, gene ontology, semantic association capabilities , led us connect differentially expressed metabolites G-protein signaling SRC. Then, associated SRC IL6 signaling. Subsequently, found associations SRC, Activin BMP Lastly, analyzed several existing novel pharmacological treatments PH. elucidated interplay between G-protein, interleukin 6, activin, Those pathways regulate hallmark processes PH, vasoconstriction, endothelial barrier function, cell proliferation, apoptosis. results highlight importance ERK1, AKT, MLC activity molecular affected by also converge these molecules. Importantly, sotatercept simultaneously. present study shows power graphs using ’s diverse set analytics functionalities developing knowledge-driven drug their interactions. We believe presented approach will be valuable future studies other diseases,

Language: Английский

Tannic acid and carboxymethyl chitosan-based multi-functional double-layered hydrogel with pH-stimulated response behavior for smart real-time infection monitoring and wound treatment DOI
Yanhong Li, Xinyan Qu, Quanbo Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 261, P. 129042 - 129042

Published: Dec. 29, 2023

Language: Английский

Citations

14
Diagnostic and prognostic biomarkers at idiopathic pulmonary arterial hypertension DOI Creative Commons
T. T. Nurpissova, Dana Taizhanova, G. Zh. Abildinova

et al.

Medicine and ecology, Journal Year: 2025, Volume and Issue: 4, P. 68 - 76

Published: Jan. 22, 2025

Introduction . Idiopathic pulmonary arterial hypertension (IPAH) is a subtype of (PAH). IPAH characterized by progressive increase in vascular resistance (PVR), which can lead to right ventricular heart failure and even mortality. The aim was study the levels C-reactive protein (CRP), endothelin-1 (ET-1) interleukin-6 (IL-6) patients with IPAH, as well assess their relationship clinical hemodynamic parameters. Materials methods Expression CRP, ET-1 IL-6 blood serum samples (n=53) control group (n=52) appropriate age/gender determined using enzyme immunoassay (ELISA). Demographic, characteristics parameters were studied according catheterization (CRH). Result discussion average age range 35.0-51.0 years, there 46 (86.8%) women this group. participants 31.0-42.0 (88.5%) women. (p < .016) .001) higher compared group, whereas level CRP = .270) no different. Meanwhile, positively correlated pressure atrium (r .728, p .360, .008), while functional class classification New York Heart Association (NYHA FC). Conclusion Levels be included diagnostic algorithm for assessing severity prognosis disease.

Language: Английский

Citations

0
New insights into pulmonary arterial hypertension: interaction between PANoptosis and perivascular inflammatory responses DOI Creative Commons

Xiaobo Su,

Yunjuan Sun, Aiguo Dai

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

Language: Английский

Citations

0
Prevalence and Determinants of Depression and Anxiety in Patients With Pulmonary Arterial Hypertension and Chronic Thromboembolic Pulmonary Hypertension DOI Open Access

Yuzuki Mitsuyama,

Ayumi Goda, Kaori Takeuchi

et al.

Circulation Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Depression and anxiety screening has not been adequately examined in patients with pulmonary hypertension (PH). We assessed depression prevalence their determinants arterial (PAH) chronic thromboembolic PH (CTEPH). This cross-sectional study included 234 (age 57 [42-68] years; 75% female; PAH/CTEPH/other: 103/126/5). Overall, 24% 26% of had (Hospital Anxiety Scale [HADS]-depression score ≥8) (HADS-anxiety respectively. was 18% 19% PAH 27% 30% CTEPH, Among PAH, significantly associated higher mean right atrial pressure (odds ratio [OR] 1.17; 95% confidence interval [CI] 1.03-1.32; P=0.013), vascular resistance (OR 1.08; CI 1.01-1.16; P=0.034), lower oxygen saturation 0.89; 0.80-0.98; P=0.021), artery 0.93; 0.87-0.99; P=0.020), reduced use phosphodiesterase-5 inhibitor 0.30; 0.11-0.86; P=0.025). In the presence a psychiatric disorder 4.71; 1.24-17.90; P=0.023). any aforementioned parameters CTEPH. Predicting based on disease severity hemodynamics challenging, making individual assessments approaches crucial.

Language: Английский

Citations

0
Hemodynamics assessment using 4D flow CMR before and after balloon pulmonary angioplasty in chronic thromboembolic pulmonary hypertension: A retrospective observational study DOI Creative Commons

Kazuto Ohno,

Kenichiro Suwa, Keitaro Akita

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract Background The effect of balloon pulmonary angioplasty (BPA) for hemodynamics in chronic thromboembolic hypertension (CTEPH), assessed using time-resolved three-dimensional cine phase-contrast cardiac magnetic resonance (4D flow CMR), remains unclear. Therefore, the present study aimed to investigate hemodynamic features artery (PA) before and after BPA diagnostic performance 4D CMR-derived predict achievement mean PA pressure (mPAP) < 30 mmHg BPA. Methods Twenty-one patients with CTEPH who underwent CMR were retrospectively enrolled. Regarding CMR, analysis included peak volume velocity at main systolic wall shear stress (WSS). Results Peak (262.8 ± 52.3 mm/s vs. 298.5 68.3 mm/s, p = 0.015) WSS (0.61 0.14 Pa 0.76 0.20 Pa, 0.002) both increased compared their values Receiver operating characteristic was performed mPAP ≥ based on revealed an area under curve 0.926 (p 0.001) (sensitivity, 0.765; specificity 0.750; cut-off, 251 mm/s) 1.00 1.00; specificity, 0.48 Pa). Conclusions Based results, imaging showed improvement Furthermore, useful metrics predicting catheter-based goal a better prognosis.

Language: Английский

Citations

0
Different Effects of Riociguat and Vericiguat on Pulmonary Vessels and Airways DOI Creative Commons

Katharina Nubbemeyer,

Julia Krabbe,

Svenja Böll

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 856 - 856

Published: April 2, 2025

Background/Objectives: Pulmonary hypertension is a progressive disease leading to right heart failure. One treatment strategy induce vasodilation via the nitric oxide–soluble guanylate cyclase–cyclic guanosine monophosphate (NO–sGC–cGMP) signaling pathway. There are currently two soluble cyclase stimulators on market: Riociguat and vericiguat, with vericiguat having longer half-life needing be taken only once day. This study investigated whether pharmacological differences between drugs affect pulmonary vessels airways. Methods: The effects of riociguat arteries, veins, airways were studied using rat precision-cut lung slices (PCLS). Vessels pretreated endothelin-1 serotonin. In isolated perfused lungs (IPL), sGC stimulation artery pressure (PAP), airway resistance, inflammatory cytokine, chemokine release quantified. Results: caused dilation in PCLS. During IPL, was more effective than reducing PAP statistically significant reduction 10%. Both potent bronchodilators preconstricted (p < 0.001). Only reduced resistance during as shown here for first time. significantly IL-6 IL-1ß levels, while also VEGF-A KC-GRO levels. Conclusions: had three main ex-vivo models: They dilated induced bronchodilation, inflammation. These properties could make useful treating diseases associated endothelial dysfunction. future, may provide an alternative bronchodilation respiratory diseases.

Language: Английский

Citations

0
Lingguizhugan decoction inhibit pulmonary hypertension by regulating macrophage IL-6 secretion via IL-33/ST2 pathway DOI

Zhengwei Dong,

Zhifeng Xue,

Min Zhang

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156822 - 156822

Published: May 1, 2025

Language: Английский

Citations

0
Causal association of depression, anxiety, cognitive performance, the brain cortical structure with pulmonary arterial hypertension: A Mendelian randomization study DOI
Zeying Zhang, Shelby Kutty,

Wei Peng

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 356, P. 356 - 362

Published: April 15, 2024

Language: Английский

Citations

3
4-hydroxysesamin protects rat with right ventricular failure due to pulmonary hypertension by inhibiting JNK/p38 MAPK signaling DOI Creative Commons
Lingnan Zhang, Xinshun Gu

Aging, Journal Year: 2024, Volume and Issue: unknown

Published: May 8, 2024

The specific mechanism of 4-hydroxysesamin (4-HS), a modification Sesamin, on right ventricular failure due to pulmonary hypertension (PH) is ominous. By creating rat model PH in vivo and artery smooth muscle cell (PASMC) hypoxia inflammation vitro, the current work aimed investigate depth molecular protective effect 4-HS. In an vitro PASMC, changes proliferation inflammatory factors were detected after treatment with 4-HS, followed by JNK/p38 MAPK signaling pathway as Western blot pathway. findings demonstrated that 4-HS was able minimize PASMC death, block pathway, resist promoting proliferation. Following that, we found could both mitigate damage brought MCT had impact rats Monocrotaline (MCT)-induced investigations. key finding this study may protect against inhibiting

Language: Английский

Citations

3
Biomarker response to infant cardiac surgery: A curious tale of inflammation! DOI
Rohan Magoon, Varun Suresh, Jes Jose

et al.

Acta Anaesthesiologica Scandinavica, Journal Year: 2024, Volume and Issue: 68(7), P. 997 - 998

Published: April 26, 2024

Data sharing not applicable—no new data generated, or the article describes entirely theoretical research.

Language: Английский

Citations

2