From immune equilibrium to tumor ecodynamics

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 10, 2024

Objectives There is no theory to quantitatively describe the complex tumor ecosystem. At same time, cancer immunotherapy considered a revolution in oncology, but methods used tumors and criteria evaluate efficacy are not keeping pace. The purpose of this study establish new for describing ecosystem, innovating characterization, establishing evaluation immunotherapy. Methods Based on mathematization immune equilibrium establishment immunodynamics previous study, method reverse was used, namely, braking force regarded as ecological force, concept momentum physics applied ecosystem series ecodynamic equations. These equations were solve fundamental problems Results A established. their component factors could be distinguish disease progression, pseudoprogression, hyperprogression On basis, adjusted established achieve equivalence activity (including immunosuppressive metabolic activity) volume, which calculate individual remission rate (ieRECIST) solid based ecodynamics. moving cube-to-force square ratio its expression proposed area under curve blood required an when known. Conclusions termed ecodynamics emphasizing both volume basic It can predicted that future will era ecotherapy targets entire

Language: Английский

Virally induced colorectal cancer drug resistance

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 383 - 424

Published: Nov. 8, 2024

Language: Английский