The Simultaneous Application of Transcranial Magnetic Stimulation and Virtual Reality to Treat Cognitive Deficits Among Stroke Patients: A Randomized Controlled Trial DOI Open Access

Priya Chauhan,

Sanjib K Das,

SD Shahanawaz

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: June 15, 2024

Background and objective Integrating virtual reality (VR) transcranial magnetic stimulation (TMS) offers a promising strategy for stroke rehabilitation, as it specifically focuses on reorganizing neural connections activating brain activity in the cortex. The main goal is to create equitable between brain's two hemispheres enhance execution of voluntary movements by stimulating central executive network (CEN) strengthen both motor cognitive abilities. This study aims propose therapeutic approach that can improve recovery overall quality life patients after stroke. Methods A total 69 participants were enrolled based certain inclusion exclusion criteria. underwent pre-assessment randomly allocated into three groups: Group 1 received simultaneous repetitive TMS (rTMS) treatment (VRT), 2 rTMS combined with sham VRT, 3 1:1:1 ratio using opaque, sealed, stapled envelopes (SNOSE). Post-assessment was carried out same measures: National Institutes Health Stroke Scale (NIHSS), Addenbrooke's Cognitive Test (ACE III), Montreal Assessment (MOCA). Statistical analysis conducted determine specific outcomes. Data IBM SPSS Statistics version 29 (IBM Corp., Armonk, NY), employing student's t-test within-group comparisons repeated measures ANOVA between-group comparisons. significance level set at 5%. Results results demonstrated statistical NIHSS scores across all groups (p<0.001). Regarding outcomes, improvements observed memory, language, performance III) within (p<0.05), significant outcomes (p = 0.009, p 0.01, 0.004, respectively), suggesting variations effects domains. However, no differences found terms fluency visuospatial skills 0.49, 0.13), indicating these Conclusions Based our findings, intervention involving compared treatments, demonstrates alleviating severity improving functions such performance. Additionally, administration more effective therapy than when they are administered separately.

Language: Английский

Advancing Neuroscience and Therapy: Insights into Genetic and Non-Genetic Neuromodulation Approaches DOI Creative Commons

Weijia Zhi,

Ying Li, Lifeng Wang

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 122 - 122

Published: Jan. 15, 2025

Neuromodulation stands as a cutting-edge approach in the fields of neuroscience and therapeutic intervention typically involving regulation neural activity through physical chemical stimuli. The purpose this review is to provide an overview evaluation different neuromodulation techniques, anticipating clearer understanding future developmental trajectories challenges faced within domain that can be achieved. This categorizes techniques into genetic methods (including optogenetics, chemogenetics, sonogenetics, magnetogenetics) non-genetic deep brain stimulation, transcranial magnetic direct current ultrasound photobiomodulation therapy, infrared neuromodulation, electromagnetic sensory stimulation multi-physical-factor techniques). By systematically evaluating principles, mechanisms, advantages, limitations, efficacy modulating neuronal potential applications interventions neurological disorders these comprehensive picture gradually emerging regarding advantages their trajectory, clinical applications. highlights significant advancements applying treat psychiatric disorders. Genetic methods, such sonogenetics magnetogenetics, have demonstrated high specificity temporal precision targeting populations, while offer noninvasive versatile options. transformative research practice underscored, emphasizing need for integration innovation technologies, optimization delivery improvement mediums, toxicity fully harness potential.

Language: Английский

Citations

1
Neuroprotective and plasticity promoting effects of repetitive transcranial magnetic stimulation (rTMS): a role for microglia DOI Creative Commons

Paolo d’Errico,

Iris Früholz,

Melanie Meyer‐Luehmann

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: 18(3), P. 810 - 821

Published: March 19, 2025

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain technique used to modulate neocortical excitability, with expanding applications in neurological and psychiatric disorders. However, the cellular molecular mechanisms underlying its effects, particularly role of microglia -the resident immune cells central nervous system- remain poorly understood. This review synthesizes recent findings on how different rTMS protocols influence microglial function under physiological conditions disease models. Emerging evidence indicates that modulates activation, promoting neuroprotective plasticity-enhancing processes not only models disorders, such as Alzheimer's Parkinson's disease, but also healthy neural circuits. While much current research has focused inflammatory profile microglia, critical aspects activity-dependent synaptic remodeling, phagocytic activity, process motility underexplored. Given substantial heterogeneity responses across regions, age, sex, well their differential roles health deeper understanding involvement rTMS-induced plasticity essential. Future studies should integrate selective manipulation advanced structural, functional, profiling techniques clarify causal involvement. Addressing these gaps will be pivotal optimizing maximizing therapeutic potential spectrum neuropsychiatric conditions.

Language: Английский

Citations

1
Harnessing Brain Plasticity: The Therapeutic Power of Repetitive Transcranial Magnetic Stimulation (rTMS) and Theta Burst Stimulation (TBS) in Neurotransmitter Modulation, Receptor Dynamics, and Neuroimaging for Neurological Innovations DOI Creative Commons
Minoo Sharbafshaaer, Giovanni Cirillo, Fabrizio Esposito

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2506 - 2506

Published: Nov. 1, 2024

Transcranial magnetic stimulation (TMS) methods have become exciting techniques for altering brain activity and improving synaptic plasticity, earning recognition as valuable non-medicine treatments a wide range of neurological disorders. Among these methods, repetitive TMS (rTMS) theta-burst (TBS) show significant promise in outcomes adults with complex neurodegenerative conditions, such Alzheimer's disease, stroke, Parkinson's etc. However, optimizing their effects remains challenge due to variability how patients respond limited understanding interact crucial neurotransmitter systems. This narrative review explores the mechanisms rTMS TBS, which enhance neuroplasticity functional improvement. We specifically focus on GABAergic glutamatergic pathways they key receptors like N-Methyl-D-Aspartate (NMDA) AMPA receptors, play essential roles processes long-term potentiation (LTP) depression (LTD). Additionally, we investigate TBS impact connectivity, particularly concerning brain-derived neurotrophic factor (BDNF) tropomyosin-related kinase receptor type B (TrkB). Here, highlight potential this research expand our better treatment patients. Through clarifying neurobiology behind neuroimaging findings, aim develop more effective, personalized plans that effectively address challenges posed by disorders ultimately quality neurorehabilitation services provide future directions patients' care.

Language: Английский

Citations

7
The effectiveness and safety of noninvasive brain stimulation technology combined with speech training on aphasia after stroke: A systematic review and meta-analysis DOI Creative Commons

Congli Han,

Jiqin Tang,

Bingshun Tang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(2), P. e36880 - e36880

Published: Jan. 12, 2024

Background: Although the effectiveness of noninvasive brain stimulation (NIBS) technology in assisting rehabilitation is widely recognized, its therapeutic efficacy patients with poststroke aphasia (PSA) requires further validation. Here, we aimed to explore and safety NIBS technique combined speech training PSA by traditional Meta-analysis compare intervention effects 2 techniques Network meta-analysis. Methods: Randomized controlled trials for treating 9 databases, including Web Science, PubMed, CNKI, clinical trial registries were searched computer. Literature screening was performed using EndNote X9 software, data analysis presentation results RevMan 5.4.1 Stata 17.0 software. Results: Screening yielded 17 studies 1013 PSA. showed that quotient scores higher group than control [standardized mean difference (SMD) = 1.06, 95% confidence interval (CI) (0.63, 1.49), Z 4.80, P < .00001]; Western battery on all 4 subscales those group, spontaneous language score [SMD 0.62, CI (0.46, 0.78), 7.52, .00001], listening comprehension 0.46, (0.30, 0.62), 5.62, repetition 1.14, (0.59, 1.70), 4.04, .0001], naming (0.79, 1.32), 7.85, The effective rate [odd ratio 4.19, (2.39, 7.37), 4.99, .00001]. meta-analysis best probability ranking improving repetitive transcranial magnetic (92.2%) > direct current (55.7%). Regarding safety, it not found treat increases risk adverse reactions. Conclusion: can effectively improve recovery function minimal effects, clinic give priority r TMS

Language: Английский

Citations

5
Global research trends in acupuncture treatment for post-stroke depression: A bibliometric analysis DOI Creative Commons
Dong Li,

Larissa Tao,

Jia Yang

et al.

Complementary Therapies in Medicine, Journal Year: 2024, Volume and Issue: 84, P. 103070 - 103070

Published: Aug. 6, 2024

Post-stroke depression (PSD) is a prevalent and severe sequela of stroke. It an emotional disorder that significantly impacts functional recovery, prognosis, secondary stroke risk, mortality among survivors. The incidence rate PSD 18 %∼33 %, with symptoms such as low mood, decreased interest, sleep disorders, appetite, impaired attention, in cases, hallucinations even suicidal tendencies. While diverse therapeutic modalities are employed globally to address PSD, each approach carries its inherent advantages limitations. Notably, acupuncture stands out promising effective intervention for ameliorating enhancing prognosis. This study aims conduct bibliometric analysis scrutinize the current landscape, identify hotspots, explore frontiers research PSD.

Language: Английский

Citations

5
Efficacy of rTMS in treating functional impairment in post-stroke patients: a systematic review and meta-analysis DOI
Xiaodong Duan, Delong Huang,

Haoshu Zhong

et al.

Neurological Sciences, Journal Year: 2024, Volume and Issue: 45(8), P. 3887 - 3899

Published: March 21, 2024

Language: Английский

Citations

4
Repeated trans-spinal magnetic stimulation promotes microglial phagocytosis of myelin debris after spinal cord injury through LRP-1 DOI Creative Commons

Chenyuan Zhai,

Zun Wang,

Jili Cai

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 379, P. 114844 - 114844

Published: June 1, 2024

Spinal cord injury (SCI) is a serious trauma of the central nervous system. The clearance myelin debris critical step in functional recovery following spinal (SCI). Recent studies have begun to reveal roles for professional phagocytes system, microglia, and their receptors control neurodegenerative disease. Repeated trans-spinal magnetic stimulation (rTSMS) has been demonstrated as noninvasive SCI treatment that enhances tissue repair recovery. In this study, we investigated role molecular mechanism rTSMS on microglial phagocytosis rat model. our studies, found significantly promoted motor function rats associated with inhibition neuroinflammation glia scar formation. Immunofluorescence results further showed promotes by microglia vivo vitro. Additionally, receptor-associated protein (RAP), Low-density lipoprotein receptor-related protein-1 (LRP-1) inhibitor, could cancel accelerated after vitro experiments. Simultaneously, Elisa's western blotting respectively decreased levels soluble LRP-1(sLRP-1) LRP-1 splicing enzyme ADAM17. conclusion, promote through improve rats.

Language: Английский

Citations

4
Multimodal therapy and use of adjunctive therapies to BoNT-A in spasticity management: defining terminology to help enhance spasticity treatment DOI Creative Commons
Rajiv Reebye, Jorge Jacinto,

Alexander Balbert

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

Spasticity management should be provided within the context of a comprehensive person-centered rehabilitation program. Furthermore, active goal setting for specific spasticity interventions is also important, with well-established “more better” approach. It critical to consider adjunctive therapy and multimodal approaches if patients are not attaining their treatment goals. Often used interchangeably, there may confusion between terms therapy. Yet it imperative understand differences these achieve goals in management. Addition secondary pharmacologic or non-pharmacologic optimize efficacy initial modality, such as adding electrical stimulation casting BoNT-A, considered an Adjunctive time-specific requires added initiated period enhance primary treatment; usually 2 weeks. Multimodal integrated, patient-centric program strategies utilized concurrent/integrated sequential manner overall effect across variety spasticity-associated impairments (e.g., neural non-neural components). Moreover, approach, can help one modality. The objectives this paper clarify therapies, provide brief evidence-based review approaches, highlight clinical insights on selecting therapies

Language: Английский

Citations

4
rTMS improves cognitive function and its real-time and cumulative effect on neuronal excitability in aged mice DOI
Chong Ding,

Xiaoqiang Pan,

Rui Fu

et al.

Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149474 - 149474

Published: Jan. 1, 2025

Language: Английский

Citations

0
Repetitive Transcranial Magnetic Stimulation in Stroke Rehabilitation: A Bibliometric Review DOI Open Access
Ayesha Juhi,

Rintu Kumar Gayen,

Shreya Sharma

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Stroke is a major cause of disability globally, with rehabilitation playing crucial role in restoring lost functions. Despite advancements, many stroke survivors face persistent deficits, prompting the need for innovative approaches such as repetitive transcranial magnetic stimulation (rTMS). This non-invasive technique promotes neural plasticity and recovery by modulating cortical excitability, garnering significant research interest. bibliometric analysis rTMS was conducted to find publication trends influential studies. Data were collected from Web Science (WOS) search strings follows: TI = ((repetitive stimulation) OR rTMS) AND ((stroke) rehabilitation). The studies till 31st December 2024 included. No language or other filters applied. A total 556 identified. While analyzing data, there may be higher lower count number due overlap categories. For example, study have authors different countries, making publications according countries than 556. There growing interest context rehabilitation, substantial increase 2022, 2023, 2024. Among studies, majority articles (62.42%), followed meeting abstracts (18.41%). (n 983) fields clinical neurology (27.47%) neuroscience (27.37%), (8.55%). When 645) categorized People's Republic China had (29.92%), South Korea (11.01%), USA (10.85%), Japan (9.61%). Elsevier (15.83%) leads publishing articles, Frontiers Media (13.49%). top citation article titled "Repetitive Transcranial Magnetic Stimulation Contralesional Primary Motor Cortex Improves Hand Function After Stroke" 521 citations published journal Stroke. These findings provide valuable insights into trends, global collaboration, emphasizing potential advancing recovery. More are needed diverse geographical regions possible international collaboration.

Language: Английский

Citations

0