LEVELS OF CATHEPSIN-D AND NESTIN IN BREAST CANCER PATIENTS DOI Creative Commons

Khalid Arif

Journal of Advance Research in Medical & Health Science (ISSN 2208-2425), Journal Year: 2023, Volume and Issue: 9(10), P. 35 - 41

Published: Oct. 13, 2023

Background: Breast cancer is the second most frequently cause of deaths among women, therefore, new screening modalities could provide an extraordinary progress in understanding mechanism disease. In last decade, role Cathepsin-D (Cath-D) and Nestin which recently received attention as tumor markers, are remain unclear. Aim: Measurement levels Cath-D breast patients (BCPs) estimating association each marker to stage disease, early advanced, age study patients. Materials methods: An overall 48 adult women who attended Kirkuk Oncology Center (Kirkuk province, Iraq) diagnosed clinically BCPs; 24 at advanced stage, were selected present that carried out from December (2022) June (2023). The obtained sera tested by specific ELISA kits.

Language: Английский

Broadening Horizons: Exploring the Cathepsin Family as Therapeutic Targets for Alzheimer's Disease DOI Creative Commons
Xiaohui Liu, Xiaotong Liu,

Yue Wu

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Alzheimer's disease (AD) is an intricate neurodegenerative disorder characterized by the accumulation of misfolded proteins, including beta-amyloid (Aβ) and tau, leading to cognitive decline. Despite decades research, precise mechanisms underlying its onset progression remain elusive. Cathepsins are a family lysosomal enzymes that play vital roles in cellular processes, protein degradation regulation immune responses. Emerging evidence suggests cathepsins may be involved AD pathogenesis. can influence activation microglia astrocytes, resident cells brain. However, cathepsin dysfunction lead notably Aβ tau. In addition, dysregulated activity induce exaggerated response, promoting chronic inflammation neuronal patients with AD. By unraveling classification, functions, AD's pathogenesis, this review sheds light on their involvement devastating disease. Targeting could promising novel approach for mitigating pathological processes contribute AD, providing new avenues treatment prevention.

Language: Английский

Citations

4
Cysteine Cathepsins: From Diagnosis to Targeted Therapy of Cancer DOI Creative Commons
Ana Ercegovič Rot,

Matija Hrovatin,

Bor Bokalj

et al.

Biochimie, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 1, 2024

Language: Английский

Citations

3
Causal associations of MICB, CTSA, and MMP9 proteins with oral cancer: Mendelian randomization study DOI Creative Commons
Bowen Dong, Jian Hua, Shanni Ma

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 27, 2024

Oral cancer (ORCA) is the most prevalent histological subtype of oral malignancies in which immune modulation relevant. The goal this work was to employ Mendelian randomization (MR) investigate causal connection between immune-related proteins MICB, CTSA, MMP9, and ORCA. Open GWAS database Integrative Epidemiology Unit (IEU) accessed collect data for ORCA (ieu-b-4961), MICB (prot-a-1898), CTSA (prot-a-717) MMP9 (prot-a-1921). From 372,373 samples, dataset comprises 7,723,107 single nucleotide polymorphisms (SNPs). all have 10,534,735 SNPs 3,301 sample sizes. Then, primary SVMR implementation approaches were weighted mode, simple inverse variance (IVW), median, MR-Egger. IVW effective technique. A sensitivity study also carried out assess correctness data, with special focus devoted heterogeneity, horizontal pleiotropy, Leave-One-Out (LOO). MVMR eventually implemented as well. analysis three exposure factors (ieu-b-94, ebi-a-GCST012237) performed validate results. According results, there a noteworthy interaction (P = 0.0014), 0.0343), 0.0003). Furthermore, odds ratios (ORs) values revealed that (OR 1.0005) an risk factor, whereas 0.9994) 0.9993) security factors. robustness findings confirmed by p-values heterogeneity both greater than 0.05. result did not affect any safety or hazard features these However, P value 0.05, implying may influence on MMP9. validation outcomes datasets harmonized from previous research, thereby solidifying reliability Our investigation provided crucial resource further research subject demonstrating relationship

Language: Английский

Citations

3
Promising potential effects of resveratrol on oral and dental health maintenance: a comprehensive review DOI

Shirin Zahra Farhad,

Amirreza Karbalaeihasanesfahani,

Esmaeel Dadgar

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 21, 2024

Language: Английский

Citations

1
Potential Causal Association between Depression and Oral Diseases: A Mendelian Randomization Study DOI Open Access
Xiao‐Bin Zhang, Hehe Jiang, Linlin Zhang

et al.

Genes, Journal Year: 2023, Volume and Issue: 14(12), P. 2191 - 2191

Published: Dec. 8, 2023

Background: Globally, oral diseases are common, pose an economic burden, and significantly decline the quality of life affected individuals. Recently, researchers have substantially highlighted effect depression on disease incidence development. In this study, we elucidated correlation between diseases. Methods: Using two-sample Mendelian randomization (MR), association risk 17 was evaluated. Three methods were used to perform MR analysis: inverse variance-weighted, weighted median, MR-Egger methods. Furthermore, Cochran’s Q test, intercept Pleiotropy RESidual Sum Outlier leave-one-out analysis performed analyze sensitivity. Results: After implementing multiple test corrections, observed that genetic susceptibility associated with increased mouth ulcers, toothache, loose teeth, bleeding gums, painful chronic periodontitis, tonsil adenoid diseases, peritonsillar abscess, excessive tooth attrition. However, a causal relationship other not observed. Sensitivity confirmed robustness results. Conclusions: We several thereby providing novel viewpoint prevention treatment Our findings suggest integration control into routine clinical care enhance effectiveness treatment.

Language: Английский

Citations

3
Cathepsins as diagnostic and prognostic markers in oral cancer DOI
Punnya V. Angadi

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 239 - 252

Published: Nov. 1, 2024

Language: Английский

Citations

0
Role of Cathepsin B Expression in Oral Squamous Cell Carcinoma: A Comprehensive Review DOI Open Access
Shakti Sagar, Pravin Gadkari,

K.M. Hiwale

et al.

Cureus, Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 15, 2024

This comprehensive review delves into the intricate landscape of oral squamous cell carcinoma (OSCC) by examining role cathepsin B expression in its pathogenesis. OSCC, a prevalent and clinically significant malignancy, poses considerable global health burden, necessitating thorough exploration underlying molecular mechanisms. Cathepsin B, lysosomal cysteine protease, emerges as critical player influencing tumour initiation, invasion, metastasis. The begins with brief overview emphasizing epidemiological clinical features, followed exploring significance studying this context. In manuscript, structure function are elucidated, providing foundation for understanding aberrant OSCC. Clinical studies revealing correlations grade stage, along prognostic significance, scrutinized, offering insights potential diagnostic utility B. biological functions including impact on invasion modulation apoptosis, comprehensively discussed.

Language: Английский

Citations

0
LEVELS OF CATHEPSIN-D AND NESTIN IN BREAST CANCER PATIENTS DOI Creative Commons

Khalid Arif

Journal of Advance Research in Medical & Health Science (ISSN 2208-2425), Journal Year: 2023, Volume and Issue: 9(10), P. 35 - 41

Published: Oct. 13, 2023

Background: Breast cancer is the second most frequently cause of deaths among women, therefore, new screening modalities could provide an extraordinary progress in understanding mechanism disease. In last decade, role Cathepsin-D (Cath-D) and Nestin which recently received attention as tumor markers, are remain unclear. Aim: Measurement levels Cath-D breast patients (BCPs) estimating association each marker to stage disease, early advanced, age study patients. Materials methods: An overall 48 adult women who attended Kirkuk Oncology Center (Kirkuk province, Iraq) diagnosed clinically BCPs; 24 at advanced stage, were selected present that carried out from December (2022) June (2023). The obtained sera tested by specific ELISA kits.

Language: Английский

Citations

0