The impact of glucose metabolism on inflammatory processes in sepsis-induced acute lung injury DOI Creative Commons

Shilei Cheng,

Yufei Li, Xiaoliang Sun

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 6, 2024

Acute lung injury (ALI) is a prevalent and critical complication of sepsis, marked by high incidence mortality rates, with its pathogenesis still not being fully elucidated. Recent research has revealed significant correlation between the metabolic reprogramming glucose sepsis-associated ALI (S-ALI). Throughout course S-ALI, immune cells, including macrophages dendritic undergo shifts to accommodate intricate demands function that emerge as sepsis advances. Indeed, in S-ALI serves double-edged sword, fueling inflammatory responses initial stages subsequently initiating anti-inflammatory disease evolves. In this review, we delineate current progress concerning pathogenic mechanisms linked focus on pertinent cells implicated. We encapsulate impact onset, progression, prognosis S-ALI. Ultimately, examining key regulatory factors within intermediates enzymes, have identified potential therapeutic targets reprogramming, striving tackle inherent challenges diagnosing treating Severe Lung Injury (S-ALI) greater efficacy.

Language: Английский

The role of lactate metabolism and lactylation in pulmonary arterial hypertension DOI Creative Commons
Tao Peng,

Jian-Liang Lu,

Xiaojiao Zheng

et al.

Respiratory Research, Journal Year: 2025, Volume and Issue: 26(1)

Published: March 12, 2025

Pulmonary arterial hypertension (PAH) is a complex and progressive disease characterized by elevated pulmonary artery pressure vascular remodeling. Recent studies have underscored the pivotal role of metabolic dysregulation epigenetic modifications in pathogenesis PAH. Lactate, byproduct glycolysis, now recognized as key molecule that links cellular metabolism with activity regulation. findings indicate that, addition to altered glycolytic dysregulated. Lactate homeostasis lactylation—a novel modification—also play significant development This review synthesizes current knowledge regarding relationship between PAH, particular focus on cumulative effects lactate cells. Furthermore, lactylation, an emerging modification, discussed context By elucidating interplay lactylation this aims provide insights into potential therapeutic targets. Understanding these pathways may lead innovative strategies for managing PAH improving patient outcomes. Future research should underlying mechanisms through which influences pathophysiology thereby aiding targeted interventions.

Language: Английский

Citations

0
The Role of Lactate and Lactylation in the Dysregulation of Immune Responses in Psoriasis DOI
Xinxin Wu, Changya Liu, Caiyun Zhang

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: March 13, 2025

Language: Английский

Citations

0
Lactylome analysis reveals potential target modified proteins in the retina of form-deprivation myopia DOI Creative Commons
Jiaojiao Feng, Xiaoniao Chen, Runkuan Li

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(9), P. 110606 - 110606

Published: July 29, 2024

The biological mechanisms underlying the development of myopia have not yet been completely elucidated. retina is critical for visual signal processing, which primarily utilizes aerobic glycolysis to produce lactate as a metabolic end product. Lactate facilitates lysine lactylation (Kla), posttranslational modification essential transcriptional regulation. This study found increased glycolytic flux and accumulation in retinas form-deprived myopic guinea pigs. Subsequently, comprehensive analysis Kla levels retinal proteins revealed that was upregulated at 124 sites 92 downregulated three proteins. Functional enrichment protein interaction analyses showed significant pathways related energy metabolism, including glutathione glycolysis, hypoxia-inducible factor-1 signaling pathway. Parallel-reaction monitoring confirmed data reliability. These findings suggest connection between metabolism imbalance, providing new insights into pathogenesis myopia.

Language: Английский

Citations

3
PFKFB3 decreases α-ketoglutarate production while partial PFKFB3 knockdown in macrophages ameliorates arthritis in tumor necrosis factor-transgenic mice DOI
Xiaodong Zhu, Xiaohui Zhou,

S X Li

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114102 - 114102

Published: Jan. 26, 2025

Language: Английский

Citations

0
The Metabolic Profile of Plasma During Epileptogenesis in a Rat Model of Lithium–Pilocarpine-Induced Temporal Lobe Epilepsy DOI Creative Commons
Fatma Merve Antmen, Emir Matpan, Ekin Dongel Dayanc

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Language: Английский

Citations

0
Revealing the Effects of Lactate on Bovine SCNT Embryo Development through Transcriptome Sequencing Analyses DOI
Nannan Li, Huan Chen, Haiying Zheng

et al.

Theriogenology, Journal Year: 2025, Volume and Issue: 236, P. 137 - 146

Published: Feb. 11, 2025

Language: Английский

Citations

0
Establishment of a Lactylation‐Related Gene Signature for Hepatocellular Carcinoma Applying Bulk and Single‐Cell RNA Sequencing Analysis DOI Creative Commons
Lianghe Yu,

Yan Shi,

Zhengzhuo Zhi

et al.

International Journal of Genomics, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Lactylation is closely involved in cancer progression, but its role hepatocellular carcinoma (HCC) unclear. The present work set out to develop a lactylation-related gene (LRG) signature for HCC. Methods: lactylation score of tumor and normal groups was calculated using the variation analysis (GSVA) package. single-cell RNA sequencing (scRNA-seq) HCC performed "Seurat" Prognostic LRGs were selected by performing univariate least absolute shrinkage selection operator (LASSO) Cox regression analyses validate Riskscore model. Functional enrichment conducted (GSEA) "clusterProfiler" Genomic characteristics between different risk compared, mutational burden (TMB) "Maftools" Immune cell infiltration assessed algorithms cell-type identification estimating relative subsets transcript (CIBERSORT), microenvironment populations-counter (MCP-counter), proportions immune cells (EPIC), estimation resource (TIMER), single-sample (ssGSEA). Immunotherapy response predicted dysfunction exclusion (TIDE) algorithm. Drug sensitivity analyzed "pRRophetic" A nomogram established "rms" expressions prognostic verified vitro test, counting kit-8 (CCK-8), wound healing, transwell assays carried measure viability, migration, invasion cells. Results: score, which higher group than group, has been confirmed as an independent factor evaluation Six LRGs, including two protective genes (FTCD APCS) four (LGALS3, C1orf43, TALDO1, CCT5), identified model with strong prediction performance scRNA-seq revealed that LGALS3 largely expressed myeloid cells, while APCS, FTCD, CCT5, C1orf43 mainly hepatocytes. high-risk primarily enriched pathways occurrence development, T infiltration. Moreover, found be less responsive immunotherapy more sensitive chemotherapeutic drugs. By integrating clinical features, high predictive accuracy developed. Additionally, highly Silencing CCT5 inhibited Conclusion: developed novel LRG could considered promising therapeutic target biomarker

Language: Английский

Citations

0
A novel lactylation-related gene signature to predict prognosis and treatment response in lung adenocarcinoma DOI Creative Commons
Hongyi Zhang, Yihao Liu,

Xuanguang Li

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

Lactylation, a novel post-translational modification, has emerged as critical regulatory mechanism in various biological processes, including tumor progression. However, its role and associated gene signatures lung adenocarcinoma (LUAD) remain unclear. RNA sequencing data of LUAD patients were obtained from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Unsupervised clustering was used to identify lactylation-related genes. A risk prognostic model constructed using least absolute shrinkage selection operator regression analysis subsequently validated. nomogram then employed optimize the clinical applicability score. Additionally, algorithms explore relationship between score immune infiltration levels, with genes analyzed based on single-cell sequencing. effects RCCD1 knockdown cell proliferation migration evaluated through CCK8 transwell assays. Higher scores poorer overall survival prognosis. Immune revealed that may play regulating microenvironment. these found be chemotherapy drug sensitivity. series experiments further demonstrated promotes vitro. This study highlights their association infiltration, providing insights into potential therapeutic targets biomarkers for application.

Language: Английский

Citations

0
Mechanisms for Regulatory Effects of Exercise on Metabolic Diseases from the Lactate–Lactylation Perspective DOI Open Access

G Chen,

Jinchao Liu,

Yongbin Guo

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3469 - 3469

Published: April 8, 2025

Metabolic diseases, including cardiovascular type 2 diabetes mellitus (T2DM), osteoporosis, and non-alcoholic fatty liver disease (NAFLD), constitute a major global health burden associated with chronic morbidity mortality. Lactate, once considered as metabolic byproduct, has emerged key regulator of cellular reprogramming through lactylation, novel post-translational modification (PTM) that dynamically couples flux to chromatin remodeling. Lactylation exerts dual regulatory roles signaling molecule via GPR81/GPR4-mediated pathways substrate for the covalent histones enzymes. Pathologically, hyperlactatemia suppresses mitochondrial biogenesis, driving cardiomyopathy epigenetic silencing oxidative metabolism genes. Conversely, exercise-induced lactate surges transiently enhance insulin sensitivity AMPK/PGC-1α/GLUT4 signaling, resolve inflammation GPR81-mediated M2 macrophage polarization, restore function lactylation-dependent pathways. This review delineates lactylation spatiotemporal rheostat: dysregulation perpetuates disorders, whereas acute exercise-mediated remodels transcriptional networks homeostasis. Future research should integrate multiomics clarify lactylation's dynamics, tissue-specific thresholds, metabolism-immunity interactions, metabolic-epigenetic crosstalk precision management diseases.

Language: Английский

Citations

0
A novel lactylation-related gene signature for diagnostic and therapeutic insights in acute myocardial infarction DOI Creative Commons
Yi Tao, Qian Lei

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1)

Published: April 28, 2025

Language: Английский

Citations

0