How Dietary Habits and Nutritional Deficiencies Relate to Hyponatremia in Older Adults DOI Creative Commons
Maaha Ayub, Meher Angez, Nabiha B. Musavi

et al.

Journal of Ageing and Longevity, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 1

Published: Dec. 24, 2024

Hyponatremia, a common electrolyte imbalance in older adults, results from physiological aging, medication use, and comorbidities, with significant implications for morbidity quality of life. This narrative review aims to explore the impact dietary habits nutritional deficiencies on development management hyponatremia this population. A literature search identified relevant studies addressing risk factors related sodium balance, intake, nutrition. The key findings reveal that low age-related changes increase vulnerability its associated risks, including cognitive decline falls. Nutritional strategies, such as optimizing protein intake reducing processed food consumption, may offer preventative benefits. Future research should focus tailored interventions establishing guidelines specific adults. Implementing strategies could improve health outcomes reduce healthcare costs populations.

Language: Английский

Exercise in Diabetic Nephropathy: Protective Effects and Molecular Mechanism DOI Open Access
Ruo-Ying Li, Liang Guo

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3605 - 3605

Published: March 23, 2024

Diabetic nephropathy (DN) is a serious complication of diabetes, and its progression influenced by factors like oxidative stress, inflammation, cell death, fibrosis. Compared to drug treatment, exercise offers cost-effective low-risk approach slowing down DN progression. Through multiple ways mechanisms, helps control blood sugar pressure reduce serum creatinine albuminuria, thereby alleviating kidney damage. This review explores the beneficial effects on improvement highlights potential mechanisms for ameliorating DN. In-depth understanding role mechanism in improving would pave way formulating safe effective programs treatment prevention

Language: Английский

Citations

6
Voluntarily wheel running protects doxorubicin-induced kidney injury by inhibiting oxidative stress through mitochondrial function DOI Creative Commons
Xin Jiang, Zeyu Wang,

Longyun Wang

et al.

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0321121 - e0321121

Published: April 1, 2025

Background Doxorubicin (DOX) has a broad anticancer spectrum and precise effects, but its clinical application is limited by severe multiorgan toxicity, among which nephrotoxicity one of the main adverse reactions. In this study, protective effect voluntary wheel running on induced DOX was observed, mechanism initially discussed. Methods Forty male C57BL/6 mice were randomly divided into control group (CTR), (EX), doxorubicin model combined with (COM). After 2 weeks exercise, sacrificed. Serum creatinine (CREA), urea nitrogen (BUN), uric acid (UA), carbon dioxide combining power (CO -CP), renal tissue apoptosis, oxidative stress mitochondrial function indicators assessed. Results Compared those in group, concentrations CREA, BUN UA decreased, number TUNEL-positive cells kidney expression antiapoptotic proteins increased, proapoptotic decreased COM group. addition, can reduce ROS MDA contents tissue, peroxide accumulation alleviate respiratory chain damage caused DOX. Conclusions Voluntary improve damage, thus playing role against This study provides new way to reactions chemotherapy combination chemical drugs.

Language: Английский

Citations

0
Preconditioning by Moderate-Intensity Exercise Prevents Gentamicin-Induced Acute Kidney Injury DOI

Esdras Guedes Fonseca,

Ana Paula Araújo-Ferreira,

Markus Berger Oliveira

et al.

International Journal of Sports Medicine, Journal Year: 2024, Volume and Issue: 45(12), P. 884 - 896

Published: July 19, 2024

Abstract A strict correlation among proximal tubule epithelial cell dysfunction, proteinuria, and modulation of the Renin-Angiotensin System Kalikrein-Kinin are crucial factors in pathogenesis Acute Kidney Injury (AKI). In this study, we investigated potential protective effect preconditioning by moderate-intensity aerobic exercise on gentamicin-induced AKI. Male Wistar rats were submitted to a treadmill protocol for 8 weeks, then injected with 80 mg/kg/day s.c. gentamicin 5 consecutive days. Four groups generated: 1) NT+SAL (control); 2) NT+AKI (non-trained AKI); 3) T+SAL (trained); 4) T+AKI (trained AKI). The group presented: impairment glomerular function parameters; increased fractional excretion Na + , K water; proteinuria urinary γ-glutamyl transferase activity (a marker tubular injury) accompanied acute necrosis; 5) an renal angiotensin-converting enzyme bradykinin B1 receptor mRNA expression. Interestingly, attenuated all alterations observed AKI (T+AKI group). Taken together, our results show that ameliorates development Our findings help expand current knowledge regarding physical kidneys during physiological pathological conditions.

Language: Английский

Citations

0
Exploring factors associated with postoperative physical activity and sedentary behavior in newly diagnosed lung cancer patients: a cross-sectional study DOI
Qiaoqiao Ma,

Guohui Zheng,

Jing Luo

et al.

Supportive Care in Cancer, Journal Year: 2024, Volume and Issue: 32(9)

Published: Aug. 21, 2024

Language: Английский

Citations

0
Physical activity in diabetic nephropathy-protective and preventive effects on the occurrence of diabetic complications DOI Creative Commons

Dominika Poborowska,

Weronika Kahan,

Weronika Szafrańska

et al.

Quality in Sport, Journal Year: 2024, Volume and Issue: 19, P. 54020 - 54020

Published: Aug. 19, 2024

Introduction and purpose Nephropathy is characterized by a gradual increase in blood pressure, urinary albumin excretion cardiovascular risk. It associated with decrease glomerular filtration rate (GFR) resulting end-stage renal failure. lowers the standard of living leads to premature death patients this complication diabetes. The article present problem diabetic nephropathy, possible diagnostic methods, treatment methods emphasis on effect physical activity improving alleviating nephropathy. State knowledge This reviews literature type 1 2 diabetes, complications special attention nephropathy exercise frequency progression complication. number people diabetes are steadily increasing. Proper diet can maintain normal glucose levels slow as well other complications. Material method available “PubMed” Google Schoolar was reviewed. focus mellitus pathogenesis, diagnosis, prevention through beneficial effects patients. Summary In our review, we managed show how big Based studies, were able prove reducing incidence Through variety modalities mechanisms, helps control sugar pressure reduce serum creatinine albuminuria, thereby kidney damage.

Language: Английский

Citations

0
Exercise: a non-drug strategy of NK cell activation DOI Creative Commons
Huixin Pan,

Rui Meng,

Zixuan Jia

et al.

Brazilian Journal of Medical and Biological Research, Journal Year: 2024, Volume and Issue: 57

Published: Jan. 1, 2024

Natural killer (NK) cells are a critical component of the innate immune system and one most sensitive to exercise. So far, it is widely believed that moderate exercise can significantly enhance proliferation activity NK cells, strengthening function. However, impact on dynamic complex process. In addition type exercise, frequency, intensity, duration also key factors. This article not only briefly summarizes activation mechanisms but delves into potential importance as non-pharmacological strategy in modulating cell enhancing system. Emerging studies have indicated timing regularity bouts might influence responses. Moreover, interaction between other components system, such cytokines chemokines, could further modulate functionality cells. The above research crucial significance for achieving deeper understanding intricate connection function, well development effective health promotion strategies. addition, needed investigate effects long-term function cell-mediated Translating these findings precisely tailored programs specific populations, taking account factors like age, status, genetic predisposition, potentially offer unprecedented prospects advancements this burgeoning field study.

Language: Английский

Citations

0
How Dietary Habits and Nutritional Deficiencies Relate to Hyponatremia in Older Adults DOI Creative Commons
Maaha Ayub, Meher Angez, Nabiha B. Musavi

et al.

Journal of Ageing and Longevity, Journal Year: 2024, Volume and Issue: 5(1), P. 1 - 1

Published: Dec. 24, 2024

Hyponatremia, a common electrolyte imbalance in older adults, results from physiological aging, medication use, and comorbidities, with significant implications for morbidity quality of life. This narrative review aims to explore the impact dietary habits nutritional deficiencies on development management hyponatremia this population. A literature search identified relevant studies addressing risk factors related sodium balance, intake, nutrition. The key findings reveal that low age-related changes increase vulnerability its associated risks, including cognitive decline falls. Nutritional strategies, such as optimizing protein intake reducing processed food consumption, may offer preventative benefits. Future research should focus tailored interventions establishing guidelines specific adults. Implementing strategies could improve health outcomes reduce healthcare costs populations.

Language: Английский

Citations

0