Immunogenic cell death: A new strategy to enhancing cancer immunotherapy DOI Creative Commons
Lei Dou, Fang Yu, Huiyuan Yang

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: Dec. 10, 2024

Immunogenic cell death (ICD) is a distinct type of stress-induced regulated that can lead to adaptive immune responses and the establishment immunological memory. ICD exhibits both similarities differences when compared apoptosis other non-apoptotic forms (RCD). The interplay between ICD-mediated immunosurveillance against cancer ability cells evade influences host-tumor interaction. Consequently, restoration development effective strategies induce have emerged as crucial considerations in treatment within context immunotherapy. To enhance comprehension setting cancer, this paper examines interconnected responsive pathways associated with ICD, corresponding biomarkers indicative mechanisms through which tumors subvert ICD. Additionally, review explores for reinstating therapeutic potential harnessing

Language: Английский

Current Advances in Photodynamic Therapy (PDT) and the Future Potential of PDT-Combinatorial Cancer Therapies DOI Open Access
Niuska Alvarez, Ana Sevilla

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(2), P. 1023 - 1023

Published: Jan. 13, 2024

Photodynamic therapy (PDT) is a two-stage treatment that implies the use of light energy, oxygen, and light-activated compounds (photosensitizers) to elicit cancerous precancerous cell death after activation (phototoxicity). The biophysical, bioengineering aspects its combinations with other strategies are highlighted in this review, both conceptually as they currently applied clinically. We further explore recent advancements PDT nanotechnology, including quantum dots innovative photosensitizers or energy donors well combination radiotherapy immunotherapy future promising cancer treatments. Finally, we emphasize potential significance organoids physiologically relevant models for PDT.

Language: Английский

Citations

95
Copper and Copper Complexes in Tumor Therapy DOI Creative Commons
Yingqiao Wang,

Tingxi Tang,

Yi Yuan

et al.

ChemMedChem, Journal Year: 2024, Volume and Issue: 19(11)

Published: March 6, 2024

Copper (Cu), a crucial trace element in physiological processes, has garnered significant interest for its involvement cancer progression and potential therapeutic applications. The regulation of cellular copper levels is essential maintaining homeostasis, as imbalances can lead to toxicity cell death. development drugs that target homeostasis emerged promising strategy anticancer treatment, with particular focus on chelators, ionophores, novel complexes. Recent research also investigated the complexes therapy.

Language: Английский

Citations

23
Photodynamic Therapy in Cancer: Insights into Cellular and Molecular Pathways DOI Creative Commons

Vincenzo Papa,

Fabiana Furci, Paola Lucia Minciullo

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 69 - 69

Published: Jan. 21, 2025

Photodynamic therapy is a non-ionizing radiation treatment that utilizes photosensitizer in combination with light to produce singlet oxygen. This oxygen induces anti-cancer effects by causing apoptotic, necrotic, or autophagic cell death tumor cells. Currently, photodynamic employed oncology treat various cancers. In the presence of oxygen, this non-invasive approach leads direct death, damage microvasculature, and induction local inflammatory response. These allow be effective treating early-stage tumors, extending survival cases where surgery not feasible, significantly improving quality life. paper, we provide state art on cytomolecular mechanisms associated pathways involved therapy. By integrating these mechanistic insights most recent advancements nanotechnology, phototherapeutic has potential become prevalent option within conventional cancer therapies, enhancing its application precision medicine.

Language: Английский

Citations

2
Advances in smart nanotechnology-supported photodynamic therapy for cancer DOI Creative Commons
Guangyao Li, Cong Wang,

Binghui Jin

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 11, 2024

Cancer has emerged as a formidable challenge in the 21st century, impacting society, public health, and economy. Conventional cancer treatments often exhibit limited efficacy considerable side effects, particularly managing advanced stages of disease. Photodynamic therapy (PDT), contemporary non-invasive therapeutic approach, employs photosensitizers (PS) conjunction with precise light wavelengths to selectively target diseased tissues, inducing generation reactive oxygen species ultimately leading cell apoptosis. In contrast conventional therapies, PDT presents lower incidence effects greater precision targeting. The integration intelligent nanotechnology into markedly improved its effectiveness, evidenced by remarkable synergistic antitumor observed utilization multifunctional nanoplatforms PDT. This paper provides concise overview principles underlying PS PDT, while also delving nanomaterial-based context treatment.

Language: Английский

Citations

12
Apoptotic efficiency of Dicoma anomala biosynthesized silver nanoparticles against A549 lung cancer cells DOI Open Access
Alexander Chota, Blassan P. George, Heidi Abrahamse

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116845 - 116845

Published: May 28, 2024

Lung cancer is one of the common forms that affects both men and women regarded as leading cause related deaths. It characterized by unregulated cell division altered cells within lung tissues. Green nanotechnology a promising therapeutic option adopted in research. Dicoma anomala (D. anomala) commonly used African medicinal plant treatment different medical conditions including cancer. In present study, silver nanoparticles (AgNPs) were synthesized using D. MeOH root extract. We evaluated anticancer efficacy AgNPs an individual well combination with pheophorbide (PPBa) mediated photodynamic therapy (PDT) vitro. UV-VIS spectroscopy, high-resolution transmission electron microscopy (HR-TEM), Scanning (SEM) energy dispersive X-ray spectroscopy (EDS) was to confirm formation D.A AgNPs. Post 24 h treatment, A549 for ATP proliferation, morphological changes supported LIVE/DEAD assay, caspase activities. All experiments repeated four times (n=4), findings being analysed SPSS statistical software version 27 set at 0.95 confidence interval. The results from study revealed dose-dependent decrease proliferation PPBa PDT on significant changes. Additionally, assay displayed increase number dead population treatments (i.e., IC

Language: Английский

Citations

7
The dual role of photodynamic therapy to treat cancer and microbial infection DOI

Farheen Akhtar,

Lama Misba,

Asad U. Khan

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(8), P. 104099 - 104099

Published: July 11, 2024

Language: Английский

Citations

4
Role of liposomes in chemoimmunotherapy of Breast cancer DOI

Fatemeh Attarian,

Ghazaleh Hatamian,

Shamim Nosrati

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 43

Published: Feb. 19, 2025

In the dynamic arena of cancer therapeutics, chemoimmunotherapy has shown tremendous promise, especially for aggressive forms breast like triple-negative (TNBC). This review delves into significant role liposomes in enhancing effectiveness by leveraging cancer-specific mechanisms such as induction immunogenic cell death (ICD), reprogramming tumor microenvironment (TME), and enabling sequential drug release. We examine innovative dual-targeting that capitalize on heterogeneity, well pH-sensitive formulations offer improved control over delivery. Unlike prior analyses, this directly links advancements preclinical research-such PAMAM dendrimer-based nanoplatforms RGD-decorated liposomes-to clinical trial results, highlighting their potential to revolutionize TNBC treatment strategies. Additionally, we address ongoing challenges related scalability, toxicity, regulatory compliance, propose future directions personalized, immune-focused nanomedicine. work not only synthesizes latest research but also offers a framework translating liposomal from laboratory practice.

Language: Английский

Citations

0
Synergistic action of combining photodynamic therapy with immunotherapy for eradicating solid tumors in animal models: a systematic review DOI
Ghazal Farahavar, Samira Sadat Abolmaali,

Roya Biabanikhankahdani

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104691 - 104691

Published: March 1, 2025

Language: Английский

Citations

0
Programable Prodrug Nanomodulator Targets Tumor Redox Homeostasis Imbalance to Amplify Disulfidptosis and Immunogenic Pyroptosis for Breast Tumor Immunotherapy DOI Open Access
Ayeskanta Mohanty, Adityanarayan Mohapatra,

Woojin Yang

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Despite the great potential of photodynamic therapy (PDT), its success remains compromised by abnormal redox homeostasis tumor cells, which supports survival, growth, and resistance to oxidative therapeutic interventions neutralizing reactive oxygen species (ROS). To overcome this barrier, a multifunctional prodrug nanomodulator (Pro@FLNC) is designed induce disulfidptosis immunogenic pyroptosis trigger an antitumor immune response. Pro@FLNC features core–shell structure where ursolic acid (UA) Chlorin e6 (Ce6) are conjugated via GSH‐responsive linker encapsulated in DSPE‐PEG‐FA lipid shell for enhanced stability, biocompatibility, tumor‐specific targeting. Within microenvironment (TME), depletes intracellular GSH, disrupts homeostasis, releases Ce6 UA, triggering stress mitochondrial dysfunction. These mechanisms amplify ROS production, promote peroxidation, initiate disulfidptosis, evidenced increased SLC7A11 expression F‐actin collapse. Elevated levels metabolic imbalance‐triggered further activate pyroptosis, releasing damage‐associated molecular patterns (DAMPs) that stimulate dendritic cell maturation cytotoxic T‐cell activation. Together, reshapes TME, reduces immunosuppressive promotes CD8 + infiltration, effectively suppressing primary tumors metastases. This programmed offers promising strategy enhance PDT immunotherapy advanced breast cancer.

Language: Английский

Citations

0
Photodynamic therapy in esophageal cancer: trends, innovations, and future directions from a global perspective (1985–2024) DOI Creative Commons
Y. Chen, Feng Guo,

Harish Rao

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: May 14, 2025

Language: Английский

Citations

0