Targeting Glycolytic Reprogramming in Cholangiocarcinoma: A Novel Approach for Metabolic Therapy DOI Creative Commons
Liyuan Hao, Shenghao Li, Qing Peng

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 9665 - 9681

Published: Nov. 1, 2024

Cholangiocarcinoma (CCA) is a highly aggressive and poorly prognostic tumor. Due to the lack of early symptoms, diagnosing CCA remains challenging, often occurring at an advanced stage. Therefore, exploring underlying mechanisms development identifying potential biomarkers therapeutic targets crucial. Recently, metabolic reprogramming in cancer cells has emerged as hallmark disease. Glycolysis been identified central component CCA, with multiple signaling pathways key enzymes playing significant roles. Additionally, non-coding RNAs (ncRNAs) post-translational modifications proteins are also involved regulating glycolysis CCA. In this review, we provide comprehensive summary alterations metabolism diverse involved, they might exert impact on Overall, targeting holds considerable promise crucial strategy for enhancing outcomes addition, performed bioinformatic analysis relationship between identify investigate targets. The purpose study theoretical basis

Language: Английский

Novel post-translational modification learning signature reveals B4GALT2 as an immune exclusion regulator in lung adenocarcinoma DOI Creative Commons
Zhenfa Zhang, Dingli Wang, Guangyao Zhou

et al.

Journal for ImmunoTherapy of Cancer, Journal Year: 2025, Volume and Issue: 13(2), P. e010787 - e010787

Published: Feb. 1, 2025

Background Lung adenocarcinoma (LUAD) presents significant challenges in prognosis and treatment efficacy evaluation. While post-translational modifications are known to influence tumor progression, their prognostic value LUAD remains largely unexplored. Methods We developed a modification learning signature (PTMLS) using machine techniques, analyzing data from 1231 patients across seven global cohorts. The signature’s predicting immunotherapy response was evaluated 12 cohorts spanning multiple cancer types (n=1201). An in-house tissue cohort (n=171) used validate beta-1,4-galactosyltransferase 2’s (B4GALT2’s) significance. role of B4GALT2 immune exclusion investigated through vivo vitro experiments. Results established PTMLS exhibited exceptional predictive capabilities patient outcomes, surpassing the 98 existing indicators. system’s validated diverse malignancy categories for immunotherapeutic assessment. From biological perspective, correlations were observed between immunological parameters, whereby elevated levels characterized by attenuated responses immunologically cold neoplastic features. Within framework, identified as crucial molecular component (r=0.82, p<0.05), its heightened expression linked unfavorable clinical outcomes cases, particularly specimens exhibiting CD8-depleted phenotypes. spatial distribution patterns cell populations, specifically CD8+ T lymphocytes CD20+ B lymphocytes, elucidated multiplexed immunofluorescence analysis. Laboratory investigations subsequently B4GALT2’s regulatory on cellular expansion both laboratory cultures animal models. Significantly, suppression found enhance lymphocyte populations functional status, thereby potentiating anti-programmed death protein 1 studies. This phenomenon reduced CD62L+CD8 alongside GZMB+/CD44+/CD69+CD8 populations. Conclusion system represents an effective instrument individualized evaluation stratification identification previously unrecognized oncogenic factor involved novel therapeutic avenue optimization.

Language: Английский

Citations

5
New insights into phytochemicals via protein glycosylation focused on aging and diabetes DOI
Yihan Chen,

Suyue Lu,

Shuo Shan

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156673 - 156673

Published: March 1, 2025

Language: Английский

Citations

1
Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders DOI Creative Commons
Xiaoming Liu, Yiwen Li,

Liting Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 30, 2024

The P2X7 receptor (P2X7R), an ATP-gated ion channel, has emerged as a crucial player in neuroinflammation and promising therapeutic target for neurodegenerative disorders. This review explores the current understanding of P2X7R's structure, activation, physiological roles, focusing on its expression function microglial cells. article examines receptor's involvement calcium signaling, polarization, well role pathogenesis Alzheimer's disease, Parkinson's multiple sclerosis, amyotrophic lateral sclerosis. highlights complex nature P2X7R discussing potential neuroprotective neurotoxic effects depending disease stage context. It also addresses development antagonists their progress clinical trials, identifying key research gaps future perspectives P2X7R-targeted therapy development. By providing comprehensive overview state knowledge directions, this serves valuable resource researchers clinicians interested exploring targeting treatment

Language: Английский

Citations

7
Multi-Omics Analysis Reveals Immune Infiltration and Clinical Significance of Phosphorylation Modification Enzymes in Lung Adenocarcinoma DOI Open Access

Deyu Long,

Yanheng Ding,

Peng Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1066 - 1066

Published: Jan. 26, 2025

Protein phosphorylation is a dynamic and reversible modification involved in almost all cellular processes. Numerous investigations have shown that protein enzymes (PPMEs) regulate play an important role the occurrence treatment of tumors. However, there still lack effective insights into value PPMEs classification patients with lung adenocarcinoma (LUAD). Here, four topological algorithms identified 15 hub from protein–protein interaction (PPI) network. This PPI network was constructed using 124 significantly correlated 35 cancer hallmark-related pathways. Our study illustrates these can affect survival LUAD form somatic mutation or expression perturbation. Consistency clustering based on recognized two subtypes (namely cluster1 cluster2) LUAD. Compared cluster1, prognosis cluster2 worse. disparity probably attributed to higher tumor burden, male proportion, more significant disturbance cluster2. Moreover, also different characteristics terms immune activity, infiltration level, immunotherapy response, drug sensitivity. We PSig scoring system by principal component analysis algorithm estimate level individual patients. Patients high low score groups demonstrated rate, gene cell abundance, sensitivity treatment. work reveals plays non-negligible microenvironment Evaluating status contribute enhancing our cognition guiding formulation personalized strategies.

Language: Английский

Citations

0
The Role of Lactate and Lactylation in the Dysregulation of Immune Responses in Psoriasis DOI
Xinxin Wu, Changya Liu, Caiyun Zhang

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2025, Volume and Issue: 68(1)

Published: March 13, 2025

Language: Английский

Citations

0
Clinical Correlation of Transcription Factor SOX3 in Cancer: Unveiling Its Role in Tumorigenesis DOI Open Access
Helen L. Del Puerto,

Ana Paula G. S. Miranda,

Dinah Qutob

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(6), P. 777 - 777

Published: June 13, 2024

Members of the SOX (SRY-related HMG box) family transcription factors are crucial for embryonic development and cell fate determination. This review investigates role SOX3 in cancer, as aberrations expression have been implicated several cancers, including osteosarcoma, breast, esophageal, endometrial, ovarian, gastric, hepatocellular carcinomas, glioblastoma, leukemia. These dysregulations modulate key cancer outcomes such apoptosis, epithelial-mesenchymal transition (EMT), invasion, migration, cycle, proliferation, contributing to development. exhibits varied patterns correlated with clinicopathological parameters diverse tumor types. aims elucidate nuanced tumorigenesis, correlating its clinical pathological characteristics patients cellular modelsBy providing a comprehensive exploration involvement this underscores multifaceted across distinct The complexity uncovered function emphasizes need further research unravel full potential therapeutics.

Language: Английский

Citations

3
One-step fabrication of dipeptide-based bifunctional polymer for individual enrichment of glycopeptides and phosphopeptides from serum DOI

Luyan Meng,

Bing Wang, Sijia Zhang

et al.

Journal of Chromatography A, Journal Year: 2024, Volume and Issue: 1730, P. 465173 - 465173

Published: July 15, 2024

Language: Английский

Citations

3
LGR5: An emerging therapeutic target for cancer metastasis and chemotherapy resistance DOI Creative Commons
Wanqi Wang, Noor A. Lokman, Simon C. Barry

et al.

Cancer and Metastasis Reviews, Journal Year: 2025, Volume and Issue: 44(1)

Published: Jan. 17, 2025

Abstract Cancer stem cells play an important role in tumor progression and chemotherapy resistance. Leucine-rich G repeat-containing protein-coupled receptor 5 (LGR5) has been identified as a cancer cell marker several types. LGR5 is involved development via pathways including WNT/β-catenin signaling pathway. plays by promoting migration, invasion, metastasis, angiogenesis many cancers colorectal, brain, gastric, ovarian cancer. This review summarises the current knowledge on expression functional of cancers, molecular mechanisms regulated LGR5, relationship between The also includes highlights potential strategies to inhibit function. majority studies have shown that progression, metastasis resistance however, some contexts can activate tumor-suppressive negative promote progression. targeting promising anti-cancer treatment but effect complex may be dependent type, microenvironment cross-talk with other molecules

Language: Английский

Citations

0
Emerging roles of mitochondrial sirtuin SIRT5 in succinylation modification and cancer development DOI Creative Commons
Z. J. Ke, Kaikai Shen, Li Wang

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Jan. 29, 2025

Succinylation represents an emerging class of post-translational modifications (PTMs), characterized by the enzymatic or non-enzymatic transfer a negatively charged four-carbon succinyl group to ϵ-amino lysine residues, mediated succinyl-coenzyme A. Recent studies have highlighted involvement succinylation in various diseases, particularly cancer progression. Sirtuin 5 (SIRT5), member sirtuin family, has been extensively studied for its robust desuccinylase activity, alongside deacetylase function. To date, only limited number SIRT5 substrates identified. These mediate diverse physiological processes such as glucose oxidation, fatty acid ammonia detoxification, reactive oxygen species scavenging, anti-apoptosis, and inflammatory responses. The regulation these activities can occur through either same activity acting on different distinct targeting substrate. Aberrant expression closely linked tumorigenesis disease progression; however, role remains controversial. exhibits dual functionalities: it promote tumor proliferation, metastasis, drug resistance, metabolic reprogramming, thereby oncogene; conversely, also inhibit cell growth induce apoptosis, functioning suppressor gene. This review aims provide comprehensive overview current research status SIRT5. We discuss structural characteristics regulatory mechanisms, compare functions with other family members, elucidate mechanisms regulating activity. Specifically, we focus modification progression, highlighting how desuccinylation modulates development delineating underlying involved.

Language: Английский

Citations

0
Implication of protein post translational modifications in gastric cancer DOI Creative Commons

Houji Song,

Mingze Zhang, Chengwang Guo

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 4, 2025

Gastric cancer (GC) is one of the most common and highly lethal malignant tumors worldwide, its occurrence development are regulated by multiple molecular mechanisms. Post-translational modifications (PTM) forms include ubiquitylation, phosphorylation, acetylation methylation. Emerging research has highlighted lactylation glycosylation. The diverse realm PTM crosstalk linked to many critical signaling events involved in neoplastic transformation, carcinogenesis metastasis. This review provides a comprehensive overview impact on progression GC. Specifically, aberrant have been shown alter proliferation, migration, invasion capabilities GC cells. Moreover, closely associated with resistance chemotherapeutic agents Notably, this also discusses phenomenon crosstalk, highlighting interactions among their roles regulating pathways protein functions. Therefore, in-depth investigation into mechanisms targeted therapeutic strategies hold promise for advancing early diagnosis, treatment, prognostic evaluation GC, offering novel insights future directions.

Language: Английский

Citations

0