Serum biomarkers of inflammation and vascular damage upon SARS-Cov-2 mRNA vaccine in patients with thymic epithelial tumors

Clinical Chemistry and Laboratory Medicine (CCLM), Journal Year: 2024, Volume and Issue: 62(6), P. 1198 - 1205

Published: Jan. 17, 2024

Abstract Objectives Thymic epithelial tumors (TET) patients are at high risk of autoimmune and hypoimmune complications. Limited evidence is available on the potential immune-related inflammatory reactions induced by SARS-Cov-2 vaccine in this patient population. Methods In order to identify subjects higher for complications, we prospectively evaluated a panel serum biomarkers related inflammation (TNF-α, IL-1β, −6, −10, −12, −17A, IFN-α, β γ, MPO, MMP-9), vascular damage (E- P-selectin, VEGF-A, P-ANCA MCP-1) 44 TET 30 healthy controls along whole cycle. Results About 50 % (either controls) showed an increase biochemical markers endothelial with large heterogeneity values. Such appeared early, after first dose control later, second (in which observed mainly biomarkers). The values normalized about 3 months did not third, booster dose. No or complications were study no difference was terms response among showing those who experienced changes. Conclusions Our data highlight relevance Sars-Cov-2 patients, as it resulted safe prevented severe COVID-19. However, further studies awaited explore mechanisms consequences biomarkers.

Language: Английский

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Immune response of COVID-19 vaccines in solid cancer patients: A meta-analysis

Human Vaccines & Immunotherapeutics, Journal Year: 2024, Volume and Issue: 20(1)

Published: May 24, 2024

Solid cancer patients, compared to their healthy counterparts, are at a greater risk of contracting and suffering from severe complications poorer prognosis after COVID-19 infections. They also have different immune responses doses vaccination, but limited evidence is available reveal the effectiveness help guide immunization programs for this subpopulation; MEDLINE, Embase, Web Science, Cochrane Library databases, clinicaltrials.gov were used search literature. The pooled seroconversion rate was calculated using random-effects model reported with 95% confidence interval (CI); review includes 66 studies containing serological vaccination in 13,050 solid patients 8550 controls. seropositive rates first dose controls 55.2% (95% CI 45.9%–64.5% N = 18) 90.2% 80.9%–96.6% 13), respectively. second 87.6% 84.1%–90.7% 50) 98.9% 97.6%-99.7% 35), third 91.4% 85.4%–95.9% 21) 99.8% 98.1%-100.0% 4), Subgroup analysis finds that study sample size, timing antibody testing, vaccine type influence on results; Seroconversion significantly lower malignancies, especially dose, then shrinking gradually following two vaccinations, indicating subsequent or booster should be considered subpopulation.

Language: Английский

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Serum HDL and their subfractions are impaired in multisystem inflammatory syndrome in children (MIS-C)

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 21, 2025

Language: Английский

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COVID-19 in patients with thymic epithelial tumors with or without Good’s syndrome: a single-center retrospective study

BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)

Published: June 19, 2024

Abstract Introduction Thymic epithelial tumors (TETs) are rare neoplasms often associated with immune-related disorders. Patients Good’s syndrome (GS), an adult-acquired TET-related immunodeficiency, at a high risk of mortality due to infectious diseases. This study aims examine COVID-19 occurrence and severity in TET patients, or without GS. Methods Clinical records patients referred the Regional Coordinating Center for Rare Tumors Campania Region were retrospectively collected. During observation period, elapsing from March 2020 April 2023, following data collected: SARS-CoV-2 infection; severity, according National Institute Health (NIH) illness categories; treatment. assessed overall population correlated presence GS and/or other dysregulations. Results Overall, 47 included study; 27 these (57.4%) had All participants received full cycle mRNA vaccine SARS-CoV2., Thirty-one (66.0%) experienced COVID-19, whom 18 (58.0%) previously diagnosis No significant association dysregulations infection was detected (Fisher’s exact test p = 1 0.3587, respectively). Among GS, 8 (45.0%) reported score ≥ 3; whereas, only 13 (7.7%) 3. The correlation between (score 2 vs. 3) statistically ( 0.0448). syndromes found 1). Of note, all hospitalized NIH 4 5 Conclusions Our suggest that especially those require careful multidisciplinary monitoring infection, order establish tailored treatments prophylactic protocols.

Language: Английский

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A potential impact of the immunological profile of current covid-19 vaccines on pregnancy outcomes

World Journal of Advanced Research and Reviews, Journal Year: 2024, Volume and Issue: 21(2), P. 270 - 275

Published: Feb. 8, 2024

The potential impact of COVID-19 vaccination on pregnancy is still a topic question in clinical practice. This short communication briefly presents the immunological aspects current covid-19 vaccines outcomes.

Language: Английский

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