Trastornos neuropsiquiátricos asociados al Covid persistente DOI Open Access
Monserrat Montenegro S.,

Gustavo Moreira G.,

Фролова О.А.

et al.

Revista Hospital Clínico Universidad de Chile, Journal Year: 2024, Volume and Issue: 35(3), P. 197 - 210

Published: Dec. 17, 2024

Persistent COVID (PC) is the term used to describe a multisystemic and multifactorial entity, which follows acute SARS-CoV-2 infection. Symptoms must persist for three months or more define this disorder. The clinical manifestations are variable nonspecific, but have great impact on quality of life patients. Neuropsychiatric symptoms commonly reported in CP, mostly chronic fatigue, cognitive disorders, attention among others. pathophysiological mechanisms not fully known, most described hypoxia related neuronal damage, microvascular lesions, persistent proinflammatory state, activation latent viral infections, alteration blood-brain barrier. There no specific complementary tests confirm diagnosis CP. also treatment date therapies aimed at relieving improving life. This article provides comprehensive bibliographic review common neuropsychiatric including its probable proposed date.

Language: Английский

Signaling pathways in uric acid homeostasis and gout: From pathogenesis to therapeutic interventions DOI Creative Commons
Shuangling Yang, Haimei Liu, Xian-Ming Fang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 132, P. 111932 - 111932

Published: April 1, 2024

Uric acid is a product of purine degradation, and uric may have multiple physiologic roles, including the beneficial effects as an antioxidant neuroprotector, maintenance blood pressure during low salt ingestion, modulation immunity. However, overproduction metabolic acid, and/or imbalance renal secretion reabsorption, underexcretion extrarenal e.g. gut, will contribute to hyperuricemia, which common disease. Long-lasting hyperuricemia can induce formation deposition monosodium urate (MSU) crystals within joints periarticular structures. MSU further acute, intensely painful, sterile inflammation conditions named gout by NLRP3 inflammasome-mediated cleavage pro-IL-1β bioactive IL-1β. Moreover, are associated with cardiovascular disorders, e.g., hypertension, myocardial infarction, stroke, obesity, hyperlipidemia, type 2 diabetes mellitus chronic kidney Although great efforts been made scientists modern medicine, however, therapeutic strategies single target difficult exert long-term positive effects, even some these agents severe adverse effects. The Chinese used ancient classic prescriptions traditional medicine (TCM) treat diseases, gout, targets, for more than 2200 years. In this review, we discuss current understanding homeostasis, pathogenesis both TCM commonly disorder. We hope provide good references treating gout.

Language: Английский

Citations

7
Identification and mechanism elucidation of medicative diet for food therapy XQCSY in NAFLD prevention: an integrative in silico study DOI

Chenxi Ren,

Mingyuan Gao, Ning Li

et al.

Food & medicine homology., Journal Year: 2024, Volume and Issue: 1(2), P. 9420015 - 9420015

Published: Dec. 1, 2024

Language: Английский

Citations

5
Advanced SERSome-Based Artificial-Intelligence Technology for Identifying Medicinal and Edible Homologs DOI
Shuang Jiang,

Yue Zhao,

Qingyu Meng

et al.

Talanta, Journal Year: 2025, Volume and Issue: unknown, P. 127931 - 127931

Published: March 1, 2025

Language: Английский

Citations

0
Astragalus mongholicusbunge and Angelica sinensis botanical drug decoction mitigates lung inflammation through NOX4/TGF-β1/SMAD3 signaling DOI Creative Commons

Zhifeng Yang,

Yuqian Chang, Tong Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Introduction Astragalus mongholicus bunge and Angelica sinensis are botanical drugs rich in beneficial nutrients health-promoting metabolites. Their roots can be decocted to a drug decoction “Danggui Buxue Tang (DBT),” demonstrating human anti-inflammatory Methods Here, we evaluate the mitigating function of DBT on lung inflammation early fibrosis rat model. The model was established by tracheal dripping silica suspension for 28 days. Positive intervention effects were observed dose-dependent manner after consecutive gavage (1.9, 3.8, 7.6 g/kg·bw/d) days 42 To explore underlying molecular mechanism. metabolites profiled using liquid chromatograph-mass spectrometer Chemspider database. Results Lung confirmed functional tests histopathologic analysis. Metabolite target analysis identified nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) as key regulating pulmonary fibrosis. Gene ontology (GO) estimated that oxidative stress, inflammatory response, myofibroblast differentiation, extracellular matrix (ECM) deposition major pathways DBT. KEGG found might modulate through transforming growth factor-β (TGF-β) pathway. GO chord signaling pathway maps revealed NOX4 contributes TGF-β regulation. vivo analyses significantly reduces protein expression, inhibits stress responses, TGF-β1, p-SMAD3, fibronectin 1 (FN1), smooth muscle actin (α-SMA) expression. Discussion These findings demonstrate lung-protecting identify critical proteins associated with

Language: Английский

Citations

0
Characterization and association patterns of Chinese food–medicine homologous species based on big data analytics DOI

Yaqun Liu,

Chunjuan Zhou,

Yukai Wan

et al.

Journal of the Science of Food and Agriculture, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

This study employs big data analytics to explore the characteristics and association patterns of 102 Chinese food-medicine homologous (CFMH) species recognized by National Health Commission China, focusing on their medicinal attributes, flavors, associated meridians, geographical distributions. Our findings reveal that most CFMH originate from plants, particularly fruits rhizomes, are predominantly characterized as warm or neutral with a sweet flavor profile. Significant clustering was identified in southern notable associations between specific therapeutic supporting potential pathways for applications. The integration traditional medicine insights modern offers powerful approach understanding leveraging multifunctional nature species. enhances our knowledge species' health benefits, providing foundation further scientific exploration application healthcare. © 2025 Society Chemical Industry.

Language: Английский

Citations

0
Investigating Mechanisms of Sophora davidii (Franch.) Skeels Flower Extract in Treating LPS-induced Acute Pneumonia Based on Network Pharmacology DOI

Ping Chen,

Lin Cheng, Qi Jin

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 118914 - 118914

Published: Oct. 1, 2024

Language: Английский

Citations

1
The Vietnamese medicinal and food plant Abelmoschus sagittifolius (Kurz.) Merr., an underestimated resource DOI Creative Commons

Phu Loc Nguyen,

Yu‐Ling Ho,

Van Minh Le

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 216, P. 118690 - 118690

Published: May 20, 2024

In Vietnam, "Sam Bo Chinh" [Abelmoschus sagittifolius (Kurz.) Merr., Malvaceae] market has rapidly expanded following the COVID-19 pandemic due to its health benefits. Since 19th century, root been utilized in Traditional Vietnamese Medicine with properties similar fresh Ginseng, particularly for treating fatigue, neurasthenia, sore throat, and stomach ache. Similar applications of are documented Chinese Medicine, but leaf fruit also employed detoxification, phlegm expulsion, liver softening, kidney nourishment. However, further evidence is required assess medicinal value explore additional avenues development. Articles were searched on PubMed, CNKI, Google Scholar, ResearchGate, VISTA using four commonly used synonyms as keywords. Duplications articles other species then screened out. Related books, articles, websites discussed. The unique characteristics that distinctive from Malvaceae species. medicine practitioners describe A. qi yin tonifying material. Various traditional formulas patents illustrate values root, leaf, or treat digestive, respiratory, neuropsychological, genitourinary disorders. Pharmacological research phytochemical profiles highlight ability be an adjuvant treatment post-COVID-19 symptoms gastric protection, stamina enhancement, antioxidant, anti-inflammatory, anti-cancer activities, simultaneously, they suggest more potential such neuroprotection, immunomodulatory anti-hypertention. Moreover, cultivating processing techniques simple. So, production can industrialized developed into medicines functional foods. plant not countries well-studied, so a rigorous assessment pharmacological needed. Its have different uses potential.

Language: Английский

Citations

0
Integrating tradition and innovation: Health industry opportunities for ginseng with foods and medicines DOI Open Access
Wei Li

Chinese Herbal Medicines, Journal Year: 2024, Volume and Issue: 16(4), P. 487 - 488

Published: Oct. 1, 2024

Language: Английский

Citations

0
Managing Type 2 Diabetes Mellitus via the Regulation of Gut Microbiota: A Chinese Medicine Perspective DOI Open Access
C. Y. Ng, Linda L. D. Zhong,

Han Seong Ng

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3935 - 3935

Published: Nov. 18, 2024

Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and inadequate production. Given the increased frequency of T2DM health issues it can cause, there an increasing need to develop alternative management strategies. One such approach Chinese Medicine (CM), complementary therapy widely used in treatment. emphasis on gut microbiota current research, studying CM treatment via modulation could be beneficial. Scope approach: The use various methods for managing highlighted this review. Following introduction its role pathogenesis, we will review potential interactions between T2DM. Thereafter, modalities that modulate provide perspectives future research. Key findings discussion: In T2DM, Akkermansia, Bifidobacterium, Firmicutes are examples commonly imbalanced. Studies have shown therapies microbiota, leading beneficial effects as reduced inflammation, improved metabolism, immunity. Among these modalities, Herbal acupuncture most well-studied, several vivo studies demonstrated their modulating microbiota. However, underlying biomolecular mechanisms actions not well elucidated, which key area Future also investigate alternate moxibustion exercises conduct large-scale clinical trials validate effectiveness

Language: Английский

Citations

0
Trastornos neuropsiquiátricos asociados al Covid persistente DOI Open Access
Monserrat Montenegro S.,

Gustavo Moreira G.,

Фролова О.А.

et al.

Revista Hospital Clínico Universidad de Chile, Journal Year: 2024, Volume and Issue: 35(3), P. 197 - 210

Published: Dec. 17, 2024

Persistent COVID (PC) is the term used to describe a multisystemic and multifactorial entity, which follows acute SARS-CoV-2 infection. Symptoms must persist for three months or more define this disorder. The clinical manifestations are variable nonspecific, but have great impact on quality of life patients. Neuropsychiatric symptoms commonly reported in CP, mostly chronic fatigue, cognitive disorders, attention among others. pathophysiological mechanisms not fully known, most described hypoxia related neuronal damage, microvascular lesions, persistent proinflammatory state, activation latent viral infections, alteration blood-brain barrier. There no specific complementary tests confirm diagnosis CP. also treatment date therapies aimed at relieving improving life. This article provides comprehensive bibliographic review common neuropsychiatric including its probable proposed date.

Language: Английский

Citations

0