JAAD Case Reports, Journal Year: 2023, Volume and Issue: 44, P. 94 - 97
Published: Dec. 27, 2023
Language: Английский
Dentistry Journal, Journal Year: 2025, Volume and Issue: 13(2), P. 79 - 79
Published: Feb. 13, 2025
Background: Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring potential of mRNA-based therapies preventing and treating oral Objectives: This narrative review aims to evaluate current status development its preclinical health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, cancer. Methods: The synthesizes findings from studies, including research conducted animal models vitro, assess modulate immune responses promote tissue regeneration cavity. Clinical trials were only mentioned context broader areas implementation such oncology immunotherapy. Results: studies highlight capacity vaccines enhance body's response facilitate repair processes. Despite these results, challenges persist delivering effectively within complex environment. These include stability, delivery mechanisms, modulation responses. Conclusions: While offer promise revolutionizing health care, they face notable limitations concerning safety, efficacy, clinical feasibility. Overcoming obstacles through further is essential unlock full translational ensure safe effective integration into practice.
Language: Английский
Citations
1
Molecular Therapy, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 3, 2025
Periodontitis is a common dysbiotic bacteria-induced inflammatory disease characterized by alveolar bone resorption, leading to tooth loss. Interleukin-17 (IL-17) critical cytokine with dual roles in periodontium, which exerts the function of host defense, including neutrophil recruitment, phagocytosis, and mucosal immunity. However, excessive expression IL-17 causes persistent chronic inflammation, local tissue breakdown, This review highlights protective pathological functions on immunity homeostasis bone-related diseases. We also provide latest findings knockout mice periodontitis highlight complex immune responses under various experimental models. may perception management using an immune-modulating strategy.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 14, 2025
Background Immune cells play a major role in the development and progression of inflammatory malignant diseases oral mucosa. There is growing evidence that immune contribute to cancer metastases. Inflammatory carcinogenesis believed be relevant for Lichen Planus as well Leukoplakia. In addition, there periodontitis might also linked development. Yet no analysis available comparing cell composition these different neoplastic diseases. A better understanding similarities differences could eventually pave way use immunotherapy non-malignant Methods current pilot study, tissue microarray (TMA) was created total 29 patients with (PD, n=4), Leukoplakia (OL, (OLP, squamous without lymphatic metastases (OSCC N0, n=5), or N+, OSCC biopsies prior resection specimens after anti-PD1 (IT) (each n=3) healthy control gingiva (n=5). each patient two samples were analyzed. The TMA stained 4X multiplex immunofluorescent staining IL-23R, CD68, CD11c, CD163. Samples digitalized an AI-based counting performed. Statistical performed using Mann-Whitney U test. Results IL-23R expression, macrophage infiltration M2 polarization OL OLP significantly higher compared controls. showed than OL. PD trend increased controls significance. N+ N0 cases. response IT, CD11c CD163 increased. Most positive co-expressed markers. Conclusion combination 4-plex immunofluorescence suitable characterization Macrophage precursor lesions seems associated metastatic spread. IL-23 pathway inhibition potential target
Language: Английский
Citations
0
Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15
Published: April 29, 2025
Introduction Microbial dysbiosis links to mucosal immune dysregulation, but the specific bacterial contributions oral inflammation remain unclear. Escherichia coli ( E. ), a pathogen well-characterized in immunity and regulation studies, has been observed be enriched chronic inflammatory lesions was reported modulate T helper 17 cells (Th17)/T regulatory (Treg) homeostasis. Here, we developed an mucositis mouse model via tongue scratch topical application investigate its role Th17/Treg imbalance. Methods The infiltration evaluated by macroscopic photography HE staining. expression of factors tissue peripheral blood mice were detected immunohistochemical staining enzyme-linked immunosorbent assay. number Th17 Treg spleen lymphocytes with flow cytometry. Differential gene analysis, functional enrichment analysis performed using RNA-seq data from lichen planus (OLP). Results stimulation aggravated responses induced scratching lingual mucosa mice, including increased local systemic interleukin 6 (IL6), (IL17), chemokine receptor (CCR6) C-C motif ligand 20 (CCL20), proportions ratio lymphocytes. Analysis OLP revealed alterations antimicrobial associated upregulation balance. Conclusion This study supports promoting provides experimental basis for vivo perspective microorganisms.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2023, Volume and Issue: 124, P. 110916 - 110916
Published: Sept. 13, 2023
Language: Английский
Citations
2
BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Aug. 17, 2024
Preventing the progression of chronic oral graft-versus-host disease (cGVHD) is essential for maintaining health, improving quality life, minimizing functional impairment, reducing systemic complications, and addressing treatment challenges.
Language: Английский
Citations
0
Journal of Oral Microbiology, Journal Year: 2024, Volume and Issue: 16(1)
Published: Oct. 30, 2024
Oral lichen planus (OLP) is a chronic oral mucosal inflammatory disease with risk of becoming malignant. Emerging evidence suggests that microbial imbalance plays an important role in the development OLP. However, association between microbiota and metabolic features OLP still unclear.
Language: Английский
Citations
0
BMC Oral Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Dec. 24, 2024
Periodontitis is among the most prevalent inflammatory conditions and greatly impacts oral health. This study aimed to elucidate role of basement membrane-related genes in pathogenesis diagnosis periodontitis. GSE10334 was used for identification hub via differential analysis, protein-protein interaction network, MCC DMNC algorithms, evaluation LASSO regression support vector machine analysis identify markers patients with Findings were validated by GSE16134 dataset quantitative reverse transcription PCR. The regulatory interplay lncRNAs, miRNAs, mRNAs investigated through multiple databases. Immune infiltration performed assess immune landscape ITGA7 identified as a key gene periodontitis, supported learning validation expression, receiver operating characteristic from external datasets. revealed significant associations between expression numerous cells implicated Additionally, our findings suggest that lncRNA LINC-PINT significantly increased it can modulate hsa-miR-1293. potential diagnostic therapeutic target LINC-PINT/hsa-miR-1293/ITGA7 axis relationship provide new insights into molecular mechanisms underlying periodontitis highlight avenues clinical intervention.
Language: Английский
Citations
0
JAAD Case Reports, Journal Year: 2023, Volume and Issue: 44, P. 94 - 97
Published: Dec. 27, 2023
Language: Английский
Citations
1